"Vliv intramuskul\u00E1rn\u00ED aplikace kolistinu na vznik a pr\u016Fb\u011Bh experiment\u00E1ln\u011B vyvolan\u00E9 ed\u00E9mov\u00E9 nemoci selat po odstavu"@cs . . "128" . . "RIV/00027162:_____/08:#0000340!RIV09-MZE-00027162" . "6"^^ . . "Alexa, Pavel" . . "Piglets after weaning were challenged by Shiga toxigenic E. coli strain (STEC). Piglets of experimental group were intramuscularly treated with colistin. After the challenge, colonisation of the intestines was observed in both group of piglets. STEC were detected in the mesenteric lymph nodes of untreated piglets. In colistin treated group of piglets (11 piglets) oedema disease developed in 10 piglets, eigt of which died or were euthanized ante finem. In the untreated group (11 piglets) oedema disease developed in five piglets, four of which died or were euthanized. We there propose, that the STEC lysed by colistin suddenly released the shiga toxin from bacterial cells immediately after their passage through the intestinal wall. That could explain a more severe course of oedema disease in the treated piglets. Even though high amounts of STEC were presented in the lymph nodes of untreted piglets, the toxin was not released abruptly because the bacterial cells were not damaged." . . . "Veterinary Microbiology" . "365126" . "Kummer, Vladim\u00EDr" . . "000253831500016" . "Selata po odstavu byla infikov\u00E1na shigatoxigenn\u00EDm kmenem E. coli (STEC). Selat\u016Fm pokusn\u00E9 skupiny byl po dobu pokusu intramuskul\u00E1rn\u011B aplikov\u00E1n kolistin. U obou skupin bylo pozorov\u00E1no os\u00EDdlen\u00ED st\u0159eva STEC. STEC byly detekov\u00E1ny v m\u00EDzn\u00EDch uzlin\u00E1ch selat neo\u0161et\u0159en\u00FDch kolistinem. Ve skupin\u011B o\u0161et\u0159en\u00FDch kolistinem (11 selat) do\u0161lo k onemocn\u011Bn\u00ED ed\u00E9movou nemoc\u00ED u 10 selat a 8 z nich uhynulo nebo bylo utraceno ante finem. V kontroln\u00ED skupin\u011B (11 selat) onemocn\u011Blo ed\u00E9movou nemoc\u00ED 5 selat a 4 z nich uhynula nebo byla utracena ante finem. P\u0159edpokl\u00E1d\u00E1me, \u017Ee kolistin destrukc\u00ED bakteri\u00E1ln\u00ED st\u011Bny vyvolal n\u00E1hl\u00E9 uvoln\u011Bn\u00ED shiga toxinu z bun\u011Bk STEC pronikaj\u00EDc\u00ED p\u0159es st\u011Bnu st\u0159eva. To m\u016F\u017Ee vysv\u011Btlovat t\u011B\u017E\u0161\u00ED pr\u016Fb\u011Bh ed\u00E9mov\u00E9 nemoci u selat o\u0161et\u0159en\u00FDch kolistinem. U selat neo\u0161et\u0159en\u00FDch kolistinem, i kdy\u017E byly STEC ve vysok\u00FDch po\u010Dtech detekov\u00E1ny v mezenteri\u00E1ln\u00EDch m\u00EDzn\u00EDch uzlin\u00E1ch, nebyl toxin uvoln\u011Bn tak n\u00E1hle, proto\u017Ee st\u011Bny bakteri\u00E1ln\u00EDch bun\u011Bk nebyly po\u0161kozeny."@cs . "1-2" . "6"^^ . . . "Ma\u0161kov\u00E1, Jarmila" . . "The effect of intramuscular administration of colistin on the development and course of experimentally induced oedema disease in weaned piglets"@en . . "0378-1135" . . "Konstantinov\u00E1, Lucie" . . "The effect of intramuscular administration of colistin on the development and course of experimentally induced oedema disease in weaned piglets" . "Vliv intramuskul\u00E1rn\u00ED aplikace kolistinu na vznik a pr\u016Fb\u011Bh experiment\u00E1ln\u011B vyvolan\u00E9 ed\u00E9mov\u00E9 nemoci selat po odstavu"@cs . "6"^^ . "The effect of intramuscular administration of colistin on the development and course of experimentally induced oedema disease in weaned piglets" . "Z(MZE0002716201)" . "Piglets after weaning were challenged by Shiga toxigenic E. coli strain (STEC). Piglets of experimental group were intramuscularly treated with colistin. After the challenge, colonisation of the intestines was observed in both group of piglets. STEC were detected in the mesenteric lymph nodes of untreated piglets. In colistin treated group of piglets (11 piglets) oedema disease developed in 10 piglets, eigt of which died or were euthanized ante finem. In the untreated group (11 piglets) oedema disease developed in five piglets, four of which died or were euthanized. We there propose, that the STEC lysed by colistin suddenly released the shiga toxin from bacterial cells immediately after their passage through the intestinal wall. That could explain a more severe course of oedema disease in the treated piglets. Even though high amounts of STEC were presented in the lymph nodes of untreted piglets, the toxin was not released abruptly because the bacterial cells were not damaged."@en . . . "Kulich, Pavel" . "NL - Nizozemsko" . . . "Escherichia coli; ED; STEC; colonising factors"@en . "RIV/00027162:_____/08:#0000340" . "The effect of intramuscular administration of colistin on the development and course of experimentally induced oedema disease in weaned piglets"@en . "[23B0072D6D60]" . . . . . "Ham\u0159\u00EDk, Jaroslav" .