. . "6"^^ . "Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells"@en . . "232" . "Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells" . "\u0160vih\u00E1lkov\u00E1, Lenka" . "[3CB0455C17F2]" . . "Ne\u010Da, Ji\u0159\u00ED" . . . "Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells"@en . "PAHs with molecular weight 278 are mostly not covered by the monitoring programs. Although benzo[g]chrysene (BgChry) and dibenzo[a,h]anthracene have been for a long time studied as genotoxic, tumour-initiating compounds, little is known about their potential tumour-promoting effects. We investigated their impact on activation of receptor AhR, induction of xenobiotic-metabolizing enzymes, disruption of cell cycle control in confluent cell population and inhibition of gap junctional intercellular communication, using the rat liver epithelial cell line WB-F344 as a model of liver progenitor cells. The results suggest, that dibenzoanthracenes and benzochrysenes, with exception of BgChry, seem to act primarily through deregulation of cell proliferation in liver epithelial cells, which is related to their relatively high AhR-mediated activity. The disruption of cell cycle control might potentially contribute to their carcinogenic effects, as well as to carcinogenicity of complex environmental mixtures." . "Sevastyanov\u00E1, O." . . . "Dibenzoanthraceny a benzochryseny projevuj\u00ED jak genotoxick\u00E9, tak negenotoxick\u00E9 \u00FA\u010Dinky v potkan\u00EDch jatern\u00EDch 'stem-like' bu\u0148k\u00E1ch"@cs . . . . "PAHs s molekul\u00E1rn\u00ED hmotnost\u00ED 278 v\u011Bt\u0161inou nejsou zahrnuty v sou\u010Dasn\u00FDch monitorovac\u00EDch programech. P\u0159esto\u017Ee benzo[g]chrysen (BgChry) a dibenzo[a,h]anthracen jsou dlouhou dobu studov\u00E1ny jako genotoxick\u00E9, tumor-inicia\u010Dn\u00ED slou\u010Deniny, je m\u00E1lo zn\u00E1mo o mo\u017En\u00FDch tumor-promo\u010Dn\u00EDch schopnostech t\u00E9to skupiny PAHs. Zab\u00FDvali jsme se jejich vlivem na aktivaci receptoru AhR, indukci enzym\u016F metabolizuj\u00EDc\u00EDch xenobiotika, naru\u0161en\u00ED kontroly bun\u011B\u010Dn\u00E9ho cyklu v konfluentn\u00ED bun\u011B\u010Dn\u00E9 populaci a inhibici mezibun\u011B\u010Dn\u00E9 populace za pou\u017Eit\u00ED potkan\u00EDch jatern\u00EDch epiteli\u00E1ln\u00EDch bun\u011Bk WB-F344 jako modelu jatern\u00EDch progenitorov\u00FDch bun\u011Bk. V\u00FDsledky ukazuj\u00ED, \u017Ee dibenzoanthraceny a benzochryseny s v\u00FDjimkou BgChry pravd\u011Bpodobn\u011B p\u016Fsob\u00ED prost\u0159ednictv\u00EDm deregulace bun\u011B\u010Dn\u00E9 proliferace v jatern\u00EDch epiteli\u00E1ln\u00EDch bu\u0148k\u00E1ch, co\u017E souvis\u00ED s jejich relativn\u011B vysokou aktivitou \u0159\u00EDzenou AhR. Naru\u0161en\u00ED kontroly bun\u011B\u010Dn\u00E9ho cyklu by mohlo p\u0159isp\u00EDvat k jejich karcinogenn\u00EDm \u00FA\u010Dink\u016Fm, stejn\u011B jako ke karcinogenit\u011B komplexn\u00EDch environment\u00E1ln\u00EDch sm\u011Bs\u00ED."@cs . "417079" . "Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells" . . "0300-483X" . . "RIV/00027162:_____/07:#0000281!RIV08-MZE-00027162" . "Machala, Miroslav" . . . "PAHs with molecular weight 278 are mostly not covered by the monitoring programs. Although benzo[g]chrysene (BgChry) and dibenzo[a,h]anthracene have been for a long time studied as genotoxic, tumour-initiating compounds, little is known about their potential tumour-promoting effects. We investigated their impact on activation of receptor AhR, induction of xenobiotic-metabolizing enzymes, disruption of cell cycle control in confluent cell population and inhibition of gap junctional intercellular communication, using the rat liver epithelial cell line WB-F344 as a model of liver progenitor cells. The results suggest, that dibenzoanthracenes and benzochrysenes, with exception of BgChry, seem to act primarily through deregulation of cell proliferation in liver epithelial cells, which is related to their relatively high AhR-mediated activity. The disruption of cell cycle control might potentially contribute to their carcinogenic effects, as well as to carcinogenicity of complex environmental mixtures."@en . "147;159" . "Vondr\u00E1\u010Dek, Jan" . . . "P\u011Bn\u010D\u00EDkov\u00E1, Kate\u0159ina" . . "Marvanov\u00E1, So\u0148a" . "Topinka, J." . . "Toxicology" . "P(KJB6004407), Z(AV0Z50040507), Z(AV0Z50390512), Z(MZE0002716201)" . . "Kozub\u00EDk, A." . "RIV/00027162:_____/07:#0000281" . . . . "Dibenzoanthraceny a benzochryseny projevuj\u00ED jak genotoxick\u00E9, tak negenotoxick\u00E9 \u00FA\u010Dinky v potkan\u00EDch jatern\u00EDch 'stem-like' bu\u0148k\u00E1ch"@cs . "13"^^ . . . "IE - Irsko" . "aryl hydrocarbon receptor; genotoxicity; rat liver epithelial cells; benzochrysenes; dibenzoanthracenes; cell proliferation"@en . "9"^^ . . . "1-2" .