"1"^^ . . . . . "In our study, we characterized lymphocyte subsets and activity in peripheral blood (PB), spleen, mesenteric and popliteal lymph nodes in pups from birth till the age of one month and compared the results with the group of three adult dogs. In neonatalpups, lower numbers of CD3+ T-cells were detected in both the spleen and PB than in lymph nodes. In contrast to the other compartments, CD21+ B-cells prevailed in the spleen. Low numbers of CD8+ lymphocytes were characteristic in all compartmentsimmediatelyafter birth. Postnatal development was characterized by an increasing frequency of CD8+ lymphocytes in all organs. Another feature of the early period of life was a relative decrease of B-cell, particularly in the PB and spleen. Stimulationindices uponmitogen-induced proliferation increased proportionally to the age. Based on our exper. data, we have concluded that pups are born with a relatively competent immune system the structure of which markedly develops during a few postnatal weeks" . . "Canine; Development; Lymphocyte subsets; Flow cytometry; Proliferation"@en . "Lymphatic organ development in dogs: major lymphocyte subsets and activity"@en . "Lymphatic organ development in dogs: major lymphocyte subsets and activity" . "1"^^ . "V\u00FDvoj lymfatick\u00FDch org\u00E1n\u016F u psa: hlavn\u00ED populace a aktivita lymfocyt\u016F"@cs . "239;247" . "3-4" . "Lymphatic organ development in dogs: major lymphocyte subsets and activity"@en . "9"^^ . . "0165-2427" . . "RIV/00027162:_____/05:06000044!RIV06-MZE-00027162" . "[A5855497D8BE]" . "Faldyna, Martin" . . "NL - Nizozemsko" . "Lymphatic organ development in dogs: major lymphocyte subsets and activity" . "P(GA524/00/0474), P(GP524/02/P010), Z(MZE0002716201)" . "104" . . . . . "528537" . "In our study, we characterized lymphocyte subsets and activity in peripheral blood (PB), spleen, mesenteric and popliteal lymph nodes in pups from birth till the age of one month and compared the results with the group of three adult dogs. In neonatalpups, lower numbers of CD3+ T-cells were detected in both the spleen and PB than in lymph nodes. In contrast to the other compartments, CD21+ B-cells prevailed in the spleen. Low numbers of CD8+ lymphocytes were characteristic in all compartmentsimmediatelyafter birth. Postnatal development was characterized by an increasing frequency of CD8+ lymphocytes in all organs. Another feature of the early period of life was a relative decrease of B-cell, particularly in the PB and spleen. Stimulationindices uponmitogen-induced proliferation increased proportionally to the age. Based on our exper. data, we have concluded that pups are born with a relatively competent immune system the structure of which markedly develops during a few postnatal weeks"@en . . "Veterinary Immunology and Immunopathology" . . . . . . "RIV/00027162:_____/05:06000044" . . "V\u00FDvoj lymfatick\u00FDch org\u00E1n\u016F u psa: hlavn\u00ED populace a aktivita lymfocyt\u016F"@cs . . "C\u00EDlem studie bylo charakterizovat subpopulace lymfocyt\u016F a jejich aktivitu v perifern\u00ED krvi, slezin\u011B, mezenteri\u00E1ln\u00ED a poplite\u00E1ln\u00ED m\u00EDzn\u00ED uzlin\u011B u \u0161t\u011B\u0148at od narozen\u00ED do v\u011Bku jednoho m\u011Bs\u00EDce a srovnat je s v\u00FDsledky z\u00EDskan\u00FDmi u dosp\u011Bl\u00FDch ps\u016F. U novorozen\u00FDch\u0161t\u011B\u0148at bylo v krvi a slezin\u011B detekov\u00E1no ni\u017E\u0161\u00ED mno\u017Estv\u00ED CD3+ T-lymfocyt\u016F ne\u017E v m\u00EDzn\u00EDch uzlin\u00E1ch. Naopak, ve slezin\u011B bylo detekov\u00E1no nejvy\u0161\u0161\u00ED mno\u017Estv\u00ED CD21+ B-lymfocyt\u016F. Mal\u00E9 mno\u017Estv\u00ED CD8+ lymfocyt\u016F bylo charakteristick\u00E9 pro v\u0161echny studovan\u00E9 org\u00E1nybezprost\u0159edn\u011B po narozen\u00ED. Dal\u0161\u00ED postnat\u00E1ln\u00ED v\u00FDvoj byl charakterizov\u00E1n zvy\u0161uj\u00EDc\u00ED se frekvenc\u00ED CD8+ lymfocyt\u016F ve v\u0161ech studovan\u00FDch org\u00E1nech. Dal\u0161\u00EDm znakem v\u00FDvoje byl relativn\u00ED pokles B-lymfocyt\u016F zejm\u00E9na ve slezin\u011B a krvi. Stimula\u010Dn\u00ED indexy v testuproliferace lymfocyt\u016F po jej\u00ED indukci mitogeny stoupaly s v\u011Bkem. Ze studie plyne, \u017Ee \u0161t\u011B\u0148ata se rod\u00ED s relativn\u011B kompetentn\u00EDm imunitn\u00EDm syst\u00E9mem, ale jeho struktura prod\u011Bl\u00E1v\u00E1 je\u0161t\u011B zm\u011Bny v pr\u016Fb\u011Bhu n\u011Bkolika t\u00FDdn\u016F po narozen\u00ED."@cs .