"78;80" . "Genetick\u00E1 variabilita bovinn\u00EDho respira\u010Dn\u00EDho syncyta\u00E1ln\u00EDho viru"@cs . . . . "Genetick\u00E1 variabilita bovinn\u00EDho respira\u010Dn\u00EDho syncyta\u00E1ln\u00EDho viru"@cs . "80-8077-007-7" . . . "Ko\u0161ice" . "2"^^ . "Ko\u0161ice" . "RIV/00027162:_____/04:00011010" . "2004-09-09+02:00"^^ . "Univerzita veterin\u00E1rskeho lek\u00E1rstva v Ko\u0161iciach" . "Genetic variability of bovine respiratory syncytial virus" . "The study of genetic vaiability is of BRSV is based mainly on sequence analysis of glycoprotein G gene, which is the most variable viral protein. In our study, multiple sequence alignment at nucleotide and amino acid levels of 15 different BRSV isolateswas carried out. The nucleotide and amino acid sequence of proteinectodomain revealed 87.3-97.4 % and 77.2-95.7 % homology, respectively. The sequence variability has been distributed equally along the whole gene of ectodomain, howeve, the nonsynonymoussubstitutions were located predominantly in two mucin-like regions of the protein. It is conceivable that the mutations of these regions are subject to the selective immune pressure."@en . . "2"^^ . . "3"^^ . . "The study of genetic vaiability is of BRSV is based mainly on sequence analysis of glycoprotein G gene, which is the most variable viral protein. In our study, multiple sequence alignment at nucleotide and amino acid levels of 15 different BRSV isolateswas carried out. The nucleotide and amino acid sequence of proteinectodomain revealed 87.3-97.4 % and 77.2-95.7 % homology, respectively. The sequence variability has been distributed equally along the whole gene of ectodomain, howeve, the nonsynonymoussubstitutions were located predominantly in two mucin-like regions of the protein. It is conceivable that the mutations of these regions are subject to the selective immune pressure." . "Genetic variability of bovine respiratory syncytial virus"@en . . . "BRSV;G protein;genetic variability"@en . "Genetic variability of bovine respiratory syncytial virus" . . . "Studium genetick\u00E9 variability bovinn\u00EDho respira\u010Dn\u00EDho syncyti\u00E1ln\u00EDho viru je zalo\u017Eeno p\u0159edev\u0161\u00EDm na srovn\u00E1n\u00ED sekvenc\u00ED genu pro glykoprotein G, kter\u00FD je nejv\u00EDce variabiln\u00EDm virov\u00FDm proteinem. V na\u0161\u00ED studui byly srovn\u00E1ny nukleotidov\u00E9 a aminokyselinov\u00E9 sekvence 15 r\u016Fzn\u00FDch izol\u00E1t\u016F BRSV. Nukleotidov\u00E9 sekvence k\u00F3duj\u00EDc\u00ED ektodom\u00E9nu glykoproteinu G vykazovaly shodu v rozsahu 87,3-97,4 %, aminokyselinov\u00E9 pak v rozsahu 77,2-95,7 %. I kdy\u017E variabilita sekvenc\u00ED byla rozm\u00EDst\u011Bna rovnom\u011Brn\u011B pod\u00E9l cel\u00E9 d\u00E9lky genu, nesynonymn\u00ED mutace byly \u010Detn\u011Bj\u0161\u00ED ve dvou %22mucin-like%22 regionech proteinu. Mutace v t\u011Bchto regionech mohou b\u00FDt v\u00FDrazem selek\u010Dn\u00EDho tlaku imunitn\u00EDho syst\u00E9mu zv\u00ED\u0159at na virov\u00E9 proteiny."@cs . "Z(MZE0002716201)" . "RIV/00027162:_____/04:00011010!RIV/2005/MZE/M03005/N" . "Infek\u010Dn\u00E9 a parazit\u00E1rne choroby zvierat, 9.- 10.9.2004, Ko\u0161ice" . "Kova\u0159\u010D\u00EDk, Kamil" . "Genetic variability of bovine respiratory syncytial virus"@en . . . "565345" . . "[7E9429E0E9F3]" . .