"Inhibice r\u016Fstu a virulence mutant\u016F salmonel v genech phoP, rpoS a ompC pro ku\u0159ata"@cs . "Barrow, P." . "[936AE0406D5B]" . . . . . "1" . . "Intestinal colonisation-inhibition and virulence of Salmonella phoP, rpoS and ompC deletion mutants in chickens"@en . "2"^^ . "Veterinary Microbiology" . "7"^^ . "Intestinal colonisation-inhibition and virulence of Salmonella phoP, rpoS and ompC deletion mutants in chickens"@en . "RIV/00027162:_____/04:#0000146!RIV08-MZE-00027162" . "4"^^ . "Intestinal colonisation-inhibition and virulence of Salmonella phoP, rpoS and ompC deletion mutants in chickens" . "37;43" . . "Salmonella; phoP mutant; Colonisation inhibition; Live vaccine; Chicken"@en . "568773" . "RIV/00027162:_____/04:#0000146" . "Karasov\u00E1 - Gregorov\u00E1, Daniela" . "Intestinal colonisation-inhibition and virulence of Salmonella phoP, rpoS and ompC deletion mutants in chickens" . "Methner, U." . . "NL - Nizozemsko" . "In this study, mutants of Salmonella Typhimurium and Enteritidis with deletions in phoP and rpoS, either alone or in combination with ompC, were tested for their level of attenuation and their ability to inhibit the intestinal colonisation of the isogenic parent strains in chickens. Mutants with deletions only in rpoS demonstrated an unaffected potential to inhibit the intestinal colonisation of the challenge strain but were still fully virulent for the chickens. Mutants with deletions in phoP, either alone or in combination with rpoS, resulted in a high level of attenuation, unimpaired ability to colonise the gut and a nearly unaffected potential to inhibit the challenge strain from caecal colonisation. Mutants with an additional deletion in ompC revealed a reduced capacity of intestinal colonisation-inhibition when compared to the control strains and both the single rpoS and the phoP deletion mutants." . "V t\u00E9to pr\u00E1ci byli p\u0159ipraveni mutanti Salmonella Typhimurium a Enteritidis s delecemi v genech phoP a rpoS, bu\u010F samostatn\u011B anebo v kombinaci s delec\u00ED genu ompC. Tyto kmeny byly testov\u00E1ny na m\u00EDru jejich atenuace a schopnost inhibice r\u016Fstu izogenn\u00EDho divok\u00E9ho kmene p\u0159i experiment\u00E1ln\u00ED infekci ku\u0159at. Mutant s delec\u00ED pouze v genu rpoS inhiboval r\u016Fst divok\u00E9ho kmene ale jeho virulence nebyla v\u00FDrazn\u011B sn\u00ED\u017Eena. Mutanti s delec\u00ED v genu phoP, bu\u010F samostatn\u011B nebo v kombinaci s rpoS, m\u011Bli v\u00FDrazn\u011B sn\u00ED\u017Eenou virulenci a zachovanou schopnost kolonizovat st\u0159evn\u00ED trakt a inhibovat r\u016Fst divok\u00E9ho kmene. Mutanti s dodate\u010Dnou mutac\u00ED v genu ompC m\u011Bli sn\u00ED\u017Eenou schopnost kolonizovat st\u0159evn\u00ED trakt a rovn\u011B\u017E i sn\u00ED\u017Eenou schopnost inhibovat r\u016Fst divok\u00E9ho kmene."@cs . . . "Rychl\u00EDk, Ivan" . . . . "In this study, mutants of Salmonella Typhimurium and Enteritidis with deletions in phoP and rpoS, either alone or in combination with ompC, were tested for their level of attenuation and their ability to inhibit the intestinal colonisation of the isogenic parent strains in chickens. Mutants with deletions only in rpoS demonstrated an unaffected potential to inhibit the intestinal colonisation of the challenge strain but were still fully virulent for the chickens. Mutants with deletions in phoP, either alone or in combination with rpoS, resulted in a high level of attenuation, unimpaired ability to colonise the gut and a nearly unaffected potential to inhibit the challenge strain from caecal colonisation. Mutants with an additional deletion in ompC revealed a reduced capacity of intestinal colonisation-inhibition when compared to the control strains and both the single rpoS and the phoP deletion mutants."@en . . "Inhibice r\u016Fstu a virulence mutant\u016F salmonel v genech phoP, rpoS a ompC pro ku\u0159ata"@cs . . . "R" . "0378-1135" . . . "98" .