"Dose\u2013response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats"@en . "3"^^ . "Amidated pectin, Cholesterol, Rats, Serum, Liver"@en . . "RIV/00027014:_____/13:#0001857" . "The dose\u2013response efficiency and long-term effect of the hypocholesterolemic effect of octadecylpectinamide was examined in female rats fed diets containing cholesterol at 10 g/kg. In our first experiment, amidated pectin supplied at 20 g/kg, 40 g/kg and 60 g/kg significantly decreased serum cholesterol from 3,32 mol/ml (control) to 1,23 mol/ml in a dose-dependent manner. In a second experiment, the hypocholesterolemic effect of amidated pectin supplied at 20 g/kg persisted after 3 months of feeding. In both experiments, the amidated pectin significantly decreased the concentrations of cholesterol in hepatic tissue and triacylglycerols in serum. The serum concentration of aspartate aminotransferase significantly increased in rats fed amidated pectin at 60 g/kg for 4 weeks, and at 20 g/kg for 3 months. In onclusion, amidated pectin at a low dose and used for a period shorter than 3 months might be considered as an effective hypocholesterolemic and lipid-lowering agent that may substitute typical antilipidemic drugs." . "Dose\u2013response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats" . . . "70476" . "Dose\u2013response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats" . . "Carbohydrate Polymers\u00A0" . . "P(GAP503/11/2479)" . . . "5"^^ . . "RIV/00027014:_____/13:#0001857!RIV14-GA0-00027014" . . . "[671142E3E6F5]" . "http://www.vuzv.cz/sites/File/_privat/13088.pdf" . "0144-8617" . . "Marounek, Milan" . "Du\u0161kov\u00E1, Dagmar" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "Volek, Zden\u011Bk" . "10.1016/j.carbpol.2013.05.044" . "T\u016Fma, Jan" . "4"^^ . . "000323805000072" . "Taubner, Tom\u00E1\u0161" . "97" . . . "2" . . . . "Dose\u2013response efficacy and long-term effect of the hypocholesterolemic effect of octadecylpectinamide in rats"@en . "The dose\u2013response efficiency and long-term effect of the hypocholesterolemic effect of octadecylpectinamide was examined in female rats fed diets containing cholesterol at 10 g/kg. In our first experiment, amidated pectin supplied at 20 g/kg, 40 g/kg and 60 g/kg significantly decreased serum cholesterol from 3,32 mol/ml (control) to 1,23 mol/ml in a dose-dependent manner. In a second experiment, the hypocholesterolemic effect of amidated pectin supplied at 20 g/kg persisted after 3 months of feeding. In both experiments, the amidated pectin significantly decreased the concentrations of cholesterol in hepatic tissue and triacylglycerols in serum. The serum concentration of aspartate aminotransferase significantly increased in rats fed amidated pectin at 60 g/kg for 4 weeks, and at 20 g/kg for 3 months. In onclusion, amidated pectin at a low dose and used for a period shorter than 3 months might be considered as an effective hypocholesterolemic and lipid-lowering agent that may substitute typical antilipidemic drugs."@en . .