"The syndrome of systemic inflammatory response and sepsis is characterized by inflammation and defects of homeostasis. Despite many advances, sepsis represents an unresolved problem for clinicians. The concept of a hyper-inflammatory syndrome that dominated the past two decades has been challenged and at present, sepsis is seen more as a dynamic syndrome characterized by many often antagonistic phenomena. The inflammation, characterizing sepsis, does not act as a primary physiological compensatory mechanism but rather sepsis should be viewed as spanning a hyper-inflammatory response and anergy or immunoparalysis response, indeed some aspects of these may be present together. These responses will also evolve with different time courses."@en . "101282" . . . "[E2BA8C35256D]" . "Quo vadis sepsis?"@en . . "Syndrom syst\u00E9mov\u00E9 z\u00E1n\u011Btliv\u00E9 odpov\u011Bdi a sepse jsou charakterizov\u00E1ny z\u00E1n\u011Btem a poruchou homeost\u00E1zy. P\u0159esd pokroky dosa\u017Een\u00E9 v uplynul\u00FDch letech, sepse p\u0159edtsavuje dosud nevy\u0159e\u0161en\u00FD problem pro kliniky. D\u016Fle\u017Eitou charakteristikou sepse je interakce dvou subjekt\u016F - makro a mikroorganismu. Koncept hyperz\u00E1ltliv\u00E9 odpov\u011Bdi, kter\u00FD dominoval v minulosti, byl nahrazen vn\u00EDm\u00E1n\u00EDm sepse jako dynamick\u00E9ho syndromu charakterizovan\u00E9ho antagonistick\u00FDmi fenom\u00E9ny. Z\u00E1n\u011Bt charakterizuj\u00EDc\u00ED sepsi, nep\u016Fsob\u00ED prim\u00E1rn\u011B jako kompenza\u010Dn\u00ED mechanismus a sepsi dnes hodnot\u00EDme jako interakci hyperz\u00E1n\u011Btliv\u00E9 odpov\u011Bdi na stran\u011B jedn\u00E9 a imunoparal\u00FDzy na stran\u011B druh\u00E9. Ob\u011B tyto f\u00E1ze se vyskytuj\u00ED sou\u010Dasn\u011B a v r\u016Fzn\u00FDch \u010Dasov\u00FDch obdob\u00EDch pr\u016Fb\u011Bhu sepse." . . . . "Pr\u016Fcha, Miroslav" . "Quo vadio sepse?"@cs . . "Anesteziologie a intenzivn\u00ED medic\u00EDna" . "Quo vadis sepsis?"@en . "Syndrom syst\u00E9mov\u00E9 z\u00E1n\u011Btliv\u00E9 odpov\u011Bdi a sepse jsou charakterizov\u00E1ny z\u00E1n\u011Btem a poruchou homeost\u00E1zy. P\u0159esd pokroky dosa\u017Een\u00E9 v uplynul\u00FDch letech, sepse p\u0159edtsavuje dosud nevy\u0159e\u0161en\u00FD problem pro kliniky. D\u016Fle\u017Eitou charakteristikou sepse je interakce dvou subjekt\u016F - makro a mikroorganismu. Koncept hyperz\u00E1ltliv\u00E9 odpov\u011Bdi, kter\u00FD dominoval v minulosti, byl nahrazen vn\u00EDm\u00E1n\u00EDm sepse jako dynamick\u00E9ho syndromu charakterizovan\u00E9ho antagonistick\u00FDmi fenom\u00E9ny. Z\u00E1n\u011Bt charakterizuj\u00EDc\u00ED sepsi, nep\u016Fsob\u00ED prim\u00E1rn\u011B jako kompenza\u010Dn\u00ED mechanismus a sepsi dnes hodnot\u00EDme jako interakci hyperz\u00E1n\u011Btliv\u00E9 odpov\u011Bdi na stran\u011B jedn\u00E9 a imunoparal\u00FDzy na stran\u011B druh\u00E9. Ob\u011B tyto f\u00E1ze se vyskytuj\u00ED sou\u010Dasn\u011B a v r\u016Fzn\u00FDch \u010Dasov\u00FDch obdob\u00EDch pr\u016Fb\u011Bhu sepse."@cs . "1"^^ . "Quo vadio sepse?" . "N" . . . . "RIV/00023884:_____/13:#0005739!RIV14-MZ0-00023884" . . "4" . "Quo vadio sepse?" . "24" . "Quo vadio sepse?"@cs . . "1"^^ . "CZ - \u010Cesk\u00E1 republika" . "RIV/00023884:_____/13:#0005739" . . "1"^^ . "sepsis - immune dysfunction-diagnostics - therapy"@en . "1214-2158" .