<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo>	<http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/randomized%20trial> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/predkladatel>	<http://linked.opendata.cz/resource/domain/vavai/subjekt/ico%3A00023884> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/tvurceVysledku>	"O\u0161\u0165\u00E1dal, Petr" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://www.w3.org/2004/02/skos/core#prefLabel>	"Updated evidence on early statin therapy for acute coronary syndromes: Meta-analysis of 18 randomized trials involving o"@en .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/obor>	<http://linked.opendata.cz/ontology/domain/vavai/riv/obor/FA> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/idSjednocenehoVysledku>	"121466" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://purl.org/dc/terms/description>	"\u00DAVOD: \u010Casn\u00E9 obdob\u00ED po vzniku akutn\u00EDho koron\u00E1rn\u00EDho syndromu (ACS) p\u0159edstavuje kritickou f\u00E1zi srde\u010Dn\u00EDho onemocn\u011Bn\u00ED s vysok\u00FDm rizikem vzniku dal\u0161\u00EDch p\u0159\u00EDhod a \u00FAmrt\u00ED. Kr\u00E1tkodob\u00E9 \u00FA\u010Dinky \u010Dasn\u00E9 l\u00E9\u010Dby statiny u pacient\u016F trp\u00EDc\u00EDch ACS jsou doposud nejasn\u00E9. C\u00CDL: Posouzen\u00ED \u00FA\u010Dink\u016F \u010Dasn\u011B zah\u00E1jen\u00E9 l\u00E9\u010Dby statinem u pacient\u016F s ACS metaanal\u00FDzou randomizovan\u00FDch kontrolovan\u00FDch studi\u00ED (RCT). V\u00DDSLEDKY: Bylo nalezeno 18 studi\u00ED (14,303 pacient\u016F), srovn\u00E1vaj\u00EDc\u00EDch nasazen\u00ED \u010Dasn\u00E9 l\u00E9\u010Dby statinem s placebem nebo obvyklou p\u00E9\u010Di u pacient\u016F s ACS. Ve srovn\u00E1n\u00ED s placebem nebo obvyklou p\u00E9\u010D\u00ED, l\u00E9\u010Dba statinem nesn\u00ED\u017Eila kombinovan\u00FD prim\u00E1rn\u00ED endpoint smrt, nefat\u00E1ln\u00ED infarkt myokardu (IM) a mozkov\u00E1 p\u0159\u00EDhoda po 30 dnech (pom\u011Br rizika (RR) 0,93, 95% interval spolehlivosti (CI) 0,80 a\u017E 1.08) a po \u010Dty\u0159ech m\u011Bs\u00EDc\u00EDch (RR 0,93, 95% CI 0,81 a\u017E 1,06). Nebylo zji\u0161t\u011Bno \u017E\u00E1dn\u00E9 statisticky v\u00FDznamn\u00E9 sn\u00ED\u017Een\u00ED rizika celkov\u00E9 mortality, fat\u00E1ln\u00EDch i nefat\u00E1ln\u00EDch infarkt\u016F, mozkov\u00FDch p\u0159\u00EDhod, kardiovaskul\u00E1rn\u00ED mortality, revaskulariza\u010Dn\u00EDch v\u00FDkon\u016F ani akutn\u00EDch srde\u010Dn\u00EDch selh\u00E1n\u00ED za jeden a \u010Dty\u0159i m\u011Bs\u00EDce, a\u010Dkoli zde byly zaznamen\u00E1ny trendy k poklesu rizika p\u0159i l\u00E9\u010Db\u011B statinem. V\u00FDskyt epizod nestabiln\u00ED anginy pectoris byl v\u00FDznamn\u011B sn\u00ED\u017Eena za \u010Dty\u0159i m\u011Bs\u00EDce po ACS (RR 0,76, 95% CI 0,59 a\u017E 0,96). Bylo zaznamen\u00E1no dev\u011Bt osob s myopati\u00ED (zv\u00FD\u0161en\u00E9 hladiny kreatin kin\u00E1zy >10x horn\u00ED hranice normy) u pacient\u016F l\u00E9\u010Den\u00FDch statiny (0,13%) ve srovn\u00E1n\u00ED s jedn\u00EDm (0,015%) v kontroln\u00ED skupin\u011B. Z\u00E1va\u017En\u00E1 svalov\u00E1 toxicity byla v\u011Bt\u0161inou omezena na pacienty l\u00E9\u010Den\u00E9 simvastatinem 80 mg. Z\u00C1V\u011AR: Na z\u00E1klad\u011B dostupn\u00FDch d\u016Fkaz\u016F, zah\u00E1jen\u00ED l\u00E9\u010Dby statiny do 14 dn\u016F po ACS nesni\u017Euje mortalitu, v\u00FDskyt infarktu myokardu nebo c\u00E9vn\u00ED mozkov\u00E9 p\u0159\u00EDhody do \u010Dty\u0159 m\u011Bs\u00EDc\u016F od ACS, ale sni\u017Euje v\u00FDskyt nestabiln\u00ED anginy pectoris."@cs .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita>	<http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/N> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/domaciTvurceVysledku>	<http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/6757073> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo>	<http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/statin%20therapy> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/entitaPredkladatele>	<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884/predkladatel> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku>	<http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/J> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/rokUplatneniVysledku>	<http://reference.data.gov.uk/id/gregorian-year/2012> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/kontrolniKodProRIV>	"[1479A26FA9ED]" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://schema.org/numberOfPages>	"8"^^<http://www.w3.org/2001/XMLSchema#int> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo>	<http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/acute%20coronary%20syndrome> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://purl.org/dc/terms/title>	"Aktualizovan\u00E9 poznatky o \u010Dasn\u00E9 l\u00E9\u010Db\u011B statinem u akutn\u00EDho koron\u00E1rn\u00EDho syndromu: Meta-anal\u00FDza 18 randomizovan\u00FDch studi\u00ED za" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/cisloPeriodika>	"1" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://www.w3.org/2004/02/skos/core#prefLabel>	"Aktualizovan\u00E9 poznatky o \u010Dasn\u00E9 l\u00E9\u010Db\u011B statinem u akutn\u00EDho koron\u00E1rn\u00EDho syndromu: Meta-anal\u00FDza 18 randomizovan\u00FDch studi\u00ED za"@cs .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/dodaniDat>	<http://reference.data.gov.uk/id/gregorian-year/2014> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju>	<http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/S> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://www.w3.org/1999/02/22-rdf-syntax-ns#type>	<http://www.w3.org/2004/02/skos/core#Concept> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://www.w3.org/1999/02/22-rdf-syntax-ns#type>	<http://linked.opendata.cz/ontology/domain/vavai/Vysledek> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://schema.org/issn>	"0167-5273" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://purl.org/dc/terms/description>	"BACKGROUND: The short-term effects of early statin therapy in acute coronary syndromes (ACS) on clinical outcomes remain unclear. Our objective was to update the evidence on patient relevant outcomes from all randomized trials comparing early statin therapy with placebo or usual care at 1 and 4months following ACS."@en .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/aktivity>	"N" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/klicovaSlova>	"statin therapy, acute coronary syndrome, randomized trial"@en .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://www.w3.org/2004/02/skos/core#notation>	"RIV/00023884:_____/12:#0004702!RIV14-MZ0-00023884" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/pocetTvurcuVysledku>	"13"^^<http://www.w3.org/2001/XMLSchema#int> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/kodStatuVydavatele>	"GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://purl.org/dc/terms/title>	"Aktualizovan\u00E9 poznatky o \u010Dasn\u00E9 l\u00E9\u010Db\u011B statinem u akutn\u00EDho koron\u00E1rn\u00EDho syndromu: Meta-anal\u00FDza 18 randomizovan\u00FDch studi\u00ED za"@cs .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://purl.org/dc/terms/description>	"\u00DAVOD: \u010Casn\u00E9 obdob\u00ED po vzniku akutn\u00EDho koron\u00E1rn\u00EDho syndromu (ACS) p\u0159edstavuje kritickou f\u00E1zi srde\u010Dn\u00EDho onemocn\u011Bn\u00ED s vysok\u00FDm rizikem vzniku dal\u0161\u00EDch p\u0159\u00EDhod a \u00FAmrt\u00ED. Kr\u00E1tkodob\u00E9 \u00FA\u010Dinky \u010Dasn\u00E9 l\u00E9\u010Dby statiny u pacient\u016F trp\u00EDc\u00EDch ACS jsou doposud nejasn\u00E9. C\u00CDL: Posouzen\u00ED \u00FA\u010Dink\u016F \u010Dasn\u011B zah\u00E1jen\u00E9 l\u00E9\u010Dby statinem u pacient\u016F s ACS metaanal\u00FDzou randomizovan\u00FDch kontrolovan\u00FDch studi\u00ED (RCT). V\u00DDSLEDKY: Bylo nalezeno 18 studi\u00ED (14,303 pacient\u016F), srovn\u00E1vaj\u00EDc\u00EDch nasazen\u00ED \u010Dasn\u00E9 l\u00E9\u010Dby statinem s placebem nebo obvyklou p\u00E9\u010Di u pacient\u016F s ACS. Ve srovn\u00E1n\u00ED s placebem nebo obvyklou p\u00E9\u010D\u00ED, l\u00E9\u010Dba statinem nesn\u00ED\u017Eila kombinovan\u00FD prim\u00E1rn\u00ED endpoint smrt, nefat\u00E1ln\u00ED infarkt myokardu (IM) a mozkov\u00E1 p\u0159\u00EDhoda po 30 dnech (pom\u011Br rizika (RR) 0,93, 95% interval spolehlivosti (CI) 0,80 a\u017E 1.08) a po \u010Dty\u0159ech m\u011Bs\u00EDc\u00EDch (RR 0,93, 95% CI 0,81 a\u017E 1,06). Nebylo zji\u0161t\u011Bno \u017E\u00E1dn\u00E9 statisticky v\u00FDznamn\u00E9 sn\u00ED\u017Een\u00ED rizika celkov\u00E9 mortality, fat\u00E1ln\u00EDch i nefat\u00E1ln\u00EDch infarkt\u016F, mozkov\u00FDch p\u0159\u00EDhod, kardiovaskul\u00E1rn\u00ED mortality, revaskulariza\u010Dn\u00EDch v\u00FDkon\u016F ani akutn\u00EDch srde\u010Dn\u00EDch selh\u00E1n\u00ED za jeden a \u010Dty\u0159i m\u011Bs\u00EDce, a\u010Dkoli zde byly zaznamen\u00E1ny trendy k poklesu rizika p\u0159i l\u00E9\u010Db\u011B statinem. V\u00FDskyt epizod nestabiln\u00ED anginy pectoris byl v\u00FDznamn\u011B sn\u00ED\u017Eena za \u010Dty\u0159i m\u011Bs\u00EDce po ACS (RR 0,76, 95% CI 0,59 a\u017E 0,96). Bylo zaznamen\u00E1no dev\u011Bt osob s myopati\u00ED (zv\u00FD\u0161en\u00E9 hladiny kreatin kin\u00E1zy >10x horn\u00ED hranice normy) u pacient\u016F l\u00E9\u010Den\u00FDch statiny (0,13%) ve srovn\u00E1n\u00ED s jedn\u00EDm (0,015%) v kontroln\u00ED skupin\u011B. Z\u00E1va\u017En\u00E1 svalov\u00E1 toxicity byla v\u011Bt\u0161inou omezena na pacienty l\u00E9\u010Den\u00E9 simvastatinem 80 mg. Z\u00C1V\u011AR: Na z\u00E1klad\u011B dostupn\u00FDch d\u016Fkaz\u016F, zah\u00E1jen\u00ED l\u00E9\u010Dby statiny do 14 dn\u016F po ACS nesni\u017Euje mortalitu, v\u00FDskyt infarktu myokardu nebo c\u00E9vn\u00ED mozkov\u00E9 p\u0159\u00EDhody do \u010Dty\u0159 m\u011Bs\u00EDc\u016F od ACS, ale sni\u017Euje v\u00FDskyt nestabiln\u00ED anginy pectoris." .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://purl.org/dc/terms/title>	"Updated evidence on early statin therapy for acute coronary syndromes: Meta-analysis of 18 randomized trials involving o"@en .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku>	<http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/cze> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://www.w3.org/2004/02/skos/core#prefLabel>	"Aktualizovan\u00E9 poznatky o \u010Dasn\u00E9 l\u00E9\u010Db\u011B statinem u akutn\u00EDho koron\u00E1rn\u00EDho syndromu: Meta-anal\u00FDza 18 randomizovan\u00FDch studi\u00ED za" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/pocetDomacichTvurcuVysledku>	"1"^^<http://www.w3.org/2001/XMLSchema#int> .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/nazevZdroje>	"International Journal of Cardiology" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/idVysledku>	"RIV/00023884:_____/12:#0004702" .
<http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00023884%3A_____%2F12%3A%230004702%21RIV14-MZ0-00023884>	<http://linked.opendata.cz/ontology/domain/vavai/riv/svazekPeriodika>	"158" .