"active vitamin B-12, holotranscobalamin, cobalamin, deficiency of vit. B-12."@en . "Praktick\u00FD diagnostick\u00FD benefit z rutinn\u00EDho stanoven\u00ED holotranskobalaminu u pacient\u016F metabolick\u00E9 ambulance"@cs . . "1"^^ . . "19(40)" . . "Praktick\u00FD diagnostick\u00FD benefit z rutinn\u00EDho stanoven\u00ED holotranskobalaminu u pacient\u016F metabolick\u00E9 ambulance" . "Objective: Authors are commenting very good experience with routinely use of holotranscobalamin (HTC) in patients attending the metabolic surgery of Hospital Homolka within last 5 yrs. Patients and Method: Among 1000 adult or children patients attending yearly the metabolic surgery the typical cases of HTC deficiency were detected in patients with unexplained neurological, psychiatric, gastroenterological, cardiologic, obstetric, nutritional and metabolic symptoms. The MEIA AxSym Active B-12 Assay (Abbott) method was introduced in routine laboratory use instead of total vitamin B-12 estimation. Results: Typical clinical cases of patients suffering from heart attacks, pulmonary embolism, typical or atypical pernicious anemias as well as in patients with deep vein thrombosis, thromboembolism, in patients with neuronal and perception disorders, in females suffering from fertility disorders are presented in details. All these patients were detected only thanks to introducing of very efficient method for HTC estimation in the routine use in clinical chemical laboratory. Conclusion: In many typical or atypical clinical cases of known or unknown origin, the estimation of active form of vitamin B-12-HTC together with methylmalonic acid and total homocysteine could be very helpful to find the reason for corresponding diagnosis or complications."@en . . "222475" . . "RIV/00023884:_____/11:#0004638!RIV12-MZ0-00023884" . . . . . . "Praktick\u00FD diagnostick\u00FD benefit z rutinn\u00EDho stanoven\u00ED holotranskobalaminu u pacient\u016F metabolick\u00E9 ambulance" . "Klinick\u00E1 biochemie a metabolismus" . "Practical Diagnostic Benefit of Routine Holotranscobalamin Estimation in Patients From Metabolic Surgery"@en . . "Praktick\u00FD diagnostick\u00FD benefit z rutinn\u00EDho stanoven\u00ED holotranskobalaminu u pacient\u016F metabolick\u00E9 ambulance"@cs . "C\u00EDl studie:auto\u0159i popisuj\u00ED velice dobr\u00E9 zku\u0161enosti s rutinn\u00EDm stanoven\u00EDm aktivn\u00EDho vitaminu B-12-holotranskobalaminu(HTC) u pacient\u016F odeslan\u00FDch do metabolick\u00E9 ambulance Nemocnice na Homolce za posledn\u00EDch 5 let. Pacienti a metody: za rok nav\u0161t\u00EDv\u00ED ambulanci zhruba 1000 dosp\u011Bl\u00FDch i d\u011Btsk\u00FDch pacient\u016F s metabolick\u00FDmi poruchami, u kter\u00FDch je diferenci\u00E1ln\u011B diagnosticky indikov\u00E1no vy\u0161et\u0159en\u00ED HTC a stanoveno metodikou MEIA AxSym Active B-12 Assay(Abbot). V\u00FDsledky: Deficit HTC nach\u00E1zej\u00ED kromn\u011B makrocyt\u00E1rn\u00ED anemie i u pacient\u016F s nepoznan\u00FDmi neuropsychiatrick\u00FDmi, za\u017E\u00EDvac\u00EDmi,srde\u010Dn\u00EDmi,v\u00FD\u017Eivov\u00FDmi,perikoncep\u010Dn\u00EDmi probl\u00E9my. Z\u0159eteln\u00FD deficit HTC je tak prokazov\u00E1n p\u0159i mozkov\u00FDch p\u0159\u00EDhod\u00E1ch, infarktech myokardu, emboli\u00EDch pl\u00EDcnice,tromb\u00F3z, tromboemboli\u00ED,typick\u00FDch i atypick\u00FDch perniciosn\u00EDch anemi\u00ED,u ment\u00E1ln\u00EDho opo\u017Ed\u011Bn\u00ED a kognitivn\u00EDch poruch, u \u017Een trp\u00EDc\u00EDch dysfertilitou aj.Vybran\u00E9 kazuistiky jsou stru\u010Dn\u011B dokumentov\u00E1ny a dokazuj\u00ED,\u017Ee spr\u00E1vn\u00E1 diagnosa byla mo\u017En\u00E1 jen d\u00EDky zaveden\u00ED tohoto vy\u0161et\u0159en\u00ED do rutinn\u00EDho provozu laborato\u0159e. Z\u00E1v\u011Br:auto\u0159i doporu\u010Duj\u00ED vy\u0161et\u0159en\u00ED HTC u shora uveden\u00FDch klinick\u00FDch symptom\u016F, proto\u017Ee spolu se stanoven\u00EDm methylmalon\u00E1tu a homocysteinu dok\u00E1\u017Ee sn\u00ED\u017Een\u00E1 hladina HTC p\u0159ekvapiv\u011B objasnit vyvol\u00E1vaj\u00EDc\u00ED p\u0159\u00ED\u010Dinu mnoha r\u016Fznorod\u00FDch n\u00E1lez\u016F a ur\u010Dit tu spr\u00E1vnou diagnosu \u010Di pochopit neo\u010Dek\u00E1van\u00E9 komplikace." . "N" . . "Practical Diagnostic Benefit of Routine Holotranscobalamin Estimation in Patients From Metabolic Surgery"@en . "CZ - \u010Cesk\u00E1 republika" . "No.1" . . "8"^^ . "[C6BA06F15145]" . "1210-7921" . . "Vondr\u00E1\u010Dkov\u00E1, Denisa" . "RIV/00023884:_____/11:#0004638" . . "C\u00EDl studie:auto\u0159i popisuj\u00ED velice dobr\u00E9 zku\u0161enosti s rutinn\u00EDm stanoven\u00EDm aktivn\u00EDho vitaminu B-12-holotranskobalaminu(HTC) u pacient\u016F odeslan\u00FDch do metabolick\u00E9 ambulance Nemocnice na Homolce za posledn\u00EDch 5 let. Pacienti a metody: za rok nav\u0161t\u00EDv\u00ED ambulanci zhruba 1000 dosp\u011Bl\u00FDch i d\u011Btsk\u00FDch pacient\u016F s metabolick\u00FDmi poruchami, u kter\u00FDch je diferenci\u00E1ln\u011B diagnosticky indikov\u00E1no vy\u0161et\u0159en\u00ED HTC a stanoveno metodikou MEIA AxSym Active B-12 Assay(Abbot). V\u00FDsledky: Deficit HTC nach\u00E1zej\u00ED kromn\u011B makrocyt\u00E1rn\u00ED anemie i u pacient\u016F s nepoznan\u00FDmi neuropsychiatrick\u00FDmi, za\u017E\u00EDvac\u00EDmi,srde\u010Dn\u00EDmi,v\u00FD\u017Eivov\u00FDmi,perikoncep\u010Dn\u00EDmi probl\u00E9my. Z\u0159eteln\u00FD deficit HTC je tak prokazov\u00E1n p\u0159i mozkov\u00FDch p\u0159\u00EDhod\u00E1ch, infarktech myokardu, emboli\u00EDch pl\u00EDcnice,tromb\u00F3z, tromboemboli\u00ED,typick\u00FDch i atypick\u00FDch perniciosn\u00EDch anemi\u00ED,u ment\u00E1ln\u00EDho opo\u017Ed\u011Bn\u00ED a kognitivn\u00EDch poruch, u \u017Een trp\u00EDc\u00EDch dysfertilitou aj.Vybran\u00E9 kazuistiky jsou stru\u010Dn\u011B dokumentov\u00E1ny a dokazuj\u00ED,\u017Ee spr\u00E1vn\u00E1 diagnosa byla mo\u017En\u00E1 jen d\u00EDky zaveden\u00ED tohoto vy\u0161et\u0159en\u00ED do rutinn\u00EDho provozu laborato\u0159e. Z\u00E1v\u011Br:auto\u0159i doporu\u010Duj\u00ED vy\u0161et\u0159en\u00ED HTC u shora uveden\u00FDch klinick\u00FDch symptom\u016F, proto\u017Ee spolu se stanoven\u00EDm methylmalon\u00E1tu a homocysteinu dok\u00E1\u017Ee sn\u00ED\u017Een\u00E1 hladina HTC p\u0159ekvapiv\u011B objasnit vyvol\u00E1vaj\u00EDc\u00ED p\u0159\u00ED\u010Dinu mnoha r\u016Fznorod\u00FDch n\u00E1lez\u016F a ur\u010Dit tu spr\u00E1vnou diagnosu \u010Di pochopit neo\u010Dek\u00E1van\u00E9 komplikace."@cs . "15"^^ . .