"US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "American Journal of Roentgenology" . "Vymazal, Josef" . "Gadobenate dimeglumine a gadofosveset trisodium p\u0159i MR angiografii ren\u00E1ln\u00EDch tepen: Multicentrick\u00E9 intrandividu\u00E1ln\u00ED srov"@cs . "0361-803X" . "5"^^ . "N" . . . . . . . "2" . "Gadobenate dimeglumine a gadofosveset trisodium p\u0159i MR angiografii ren\u00E1ln\u00EDch tepen: Multicentrick\u00E9 intrandividu\u00E1ln\u00ED srov" . . "260186" . . "Gadobenate dimeglumine a gadofosveset trisodium p\u0159i MR angiografii ren\u00E1ln\u00EDch tepen: Multicentrick\u00E9 intraindividu\u00E1ln\u00ED srovn\u00E1n\u00ED \u00DA\u010CEL: Tato prospektivn\u00ED multicentrick\u00E1 interindividu\u00E1ln\u00ED studie byla navr\u017Eena ke srovn\u00E1n\u00ED Gadobenate dimeglumine a gadofosveset trisodium ve schv\u00E1len\u00FDch d\u00E1vk\u00E1ch s ohledem na kvalitu a diagnostickou v\u00FDt\u011B\u017Enost p\u0159i kontrastn\u00ED MR angiografii (CE-MRA) v detekci klinicky relevantn\u00ED sten\u00F3zy ren\u00E1ln\u00ED tepny. \u00DA\u010CASTN\u00CDCI A METODY: T\u0159icetdev\u011Bt jedinc\u016F (17 mu\u017E\u016F a 22 \u017Een, 38-86 let, pr\u016Fm\u011Br 62 +/- 13.3 let) se zn\u00E1mou nebo pravd\u011Bpodobnou renovaskul\u00E1rn\u00ED nemoc\u00ED podstoupilo nejprve CE-MRA s 0.1 mmol/kg gadobenate dimeglumine an\u00E1sledn\u011B 3-12 dn\u00ED pozd\u011Bji CE-MRA s 0.03 mmol/kg gadofosveset. Identick\u00E9 obrazy po\u0159\u00EDzen\u00E9 s T1 v\u00E1\u017Eenou spoiled gradient-refocused echo sekvenc\u00ED v koron\u00E1rn\u00ED rovin\u011B byly po\u0159\u00EDzeny pro 38 z 39 pacient\u016F. U 15 z 30 pacient\u016F dal\u0161\u00ED obrazy v sagit\u00E1ln\u00ED a axi\u00E1ln\u00ED rovin\u011B byly po\u0159\u00EDzeny v steady state f\u00E1zi. 34 pacient\u016F podstoupilo digit\u00E1ln\u00ED subtrak\u010Dn\u00ED angiografii, kter\u00E1 byla referenc\u00ED. T\u0159i ne\u00E1visl\u00ED a zaslepen\u00ED hodnotitel\u00E9 hodnotili zdrojov\u00E9 obr\u00E1zky a maximum- intesity projekce v rekonstrukc\u00EDch, aby stanovili klinicky relevantn\u00ED (> 50%) sten\u00F3zu ledvinn\u00E9 tepny. Diagnostick\u00E9 hodnocen\u00ED (senzitivita, specificita, p\u0159esnost, pozitivn\u00ED a negativn\u00ED prediktivn\u00ED hodnoty) byly hodnoceny pomoc\u00ED McNemar and Wald test\u016F. P\u00E1rov\u00E1 ur\u010Den\u00ED byla stanovena Wilcoxonov\u00FDm testem. Shoda hodnotitel\u016F byla stanovena pomoc\u00ED kappa anal\u00FDzy a bezpe\u010Dnost byla stanovena. V\u00DDSLEDKY: Srovn\u00E1n\u00ED first-pass obraz\u016F odhalilo lep\u0161\u00ED v\u00FDsledky z hlediska senzitivity (75.7-86.5% vs 68.4-76.3%), specificity (92.1-98.6% vs 90.5-93.9%), p\u0159esnosti (88.9-96.2% vs 85.9-90.3%), pozitivn\u00ED prediktivn\u00ED hodnoty (70.0-94.1% vs 65.0-76.3%) a negativn\u00ED prediktivn\u00ED hodnoty (70.0-94.1% vs 65.0-76.3%) pro gadobenate dimeglumine. Steady-state obrazy neprok\u00E1zaly lep\u0161\u00ED v\u00FDsledky pro gadofosveset. Shoda hodnotitel\u016F byla dobr\u00E1 a\u017E vynikaj\u00EDc\u00ED (gadobenate dimeglumine, kappa = 0.855;"@cs . "Gadobenate dimeglumine a gadofosveset trisodium p\u0159i MR angiografii ren\u00E1ln\u00EDch tepen: Multicentrick\u00E9 intraindividu\u00E1ln\u00ED srovn\u00E1n\u00ED \u00DA\u010CEL: Tato prospektivn\u00ED multicentrick\u00E1 interindividu\u00E1ln\u00ED studie byla navr\u017Eena ke srovn\u00E1n\u00ED Gadobenate dimeglumine a gadofosveset trisodium ve schv\u00E1len\u00FDch d\u00E1vk\u00E1ch s ohledem na kvalitu a diagnostickou v\u00FDt\u011B\u017Enost p\u0159i kontrastn\u00ED MR angiografii (CE-MRA) v detekci klinicky relevantn\u00ED sten\u00F3zy ren\u00E1ln\u00ED tepny. \u00DA\u010CASTN\u00CDCI A METODY: T\u0159icetdev\u011Bt jedinc\u016F (17 mu\u017E\u016F a 22 \u017Een, 38-86 let, pr\u016Fm\u011Br 62 +/- 13.3 let) se zn\u00E1mou nebo pravd\u011Bpodobnou renovaskul\u00E1rn\u00ED nemoc\u00ED podstoupilo nejprve CE-MRA s 0.1 mmol/kg gadobenate dimeglumine an\u00E1sledn\u011B 3-12 dn\u00ED pozd\u011Bji CE-MRA s 0.03 mmol/kg gadofosveset. Identick\u00E9 obrazy po\u0159\u00EDzen\u00E9 s T1 v\u00E1\u017Eenou spoiled gradient-refocused echo sekvenc\u00ED v koron\u00E1rn\u00ED rovin\u011B byly po\u0159\u00EDzeny pro 38 z 39 pacient\u016F. U 15 z 30 pacient\u016F dal\u0161\u00ED obrazy v sagit\u00E1ln\u00ED a axi\u00E1ln\u00ED rovin\u011B byly po\u0159\u00EDzeny v steady state f\u00E1zi. 34 pacient\u016F podstoupilo digit\u00E1ln\u00ED subtrak\u010Dn\u00ED angiografii, kter\u00E1 byla referenc\u00ED. T\u0159i ne\u00E1visl\u00ED a zaslepen\u00ED hodnotitel\u00E9 hodnotili zdrojov\u00E9 obr\u00E1zky a maximum- intesity projekce v rekonstrukc\u00EDch, aby stanovili klinicky relevantn\u00ED (> 50%) sten\u00F3zu ledvinn\u00E9 tepny. Diagnostick\u00E9 hodnocen\u00ED (senzitivita, specificita, p\u0159esnost, pozitivn\u00ED a negativn\u00ED prediktivn\u00ED hodnoty) byly hodnoceny pomoc\u00ED McNemar and Wald test\u016F. P\u00E1rov\u00E1 ur\u010Den\u00ED byla stanovena Wilcoxonov\u00FDm testem. Shoda hodnotitel\u016F byla stanovena pomoc\u00ED kappa anal\u00FDzy a bezpe\u010Dnost byla stanovena. V\u00DDSLEDKY: Srovn\u00E1n\u00ED first-pass obraz\u016F odhalilo lep\u0161\u00ED v\u00FDsledky z hlediska senzitivity (75.7-86.5% vs 68.4-76.3%), specificity (92.1-98.6% vs 90.5-93.9%), p\u0159esnosti (88.9-96.2% vs 85.9-90.3%), pozitivn\u00ED prediktivn\u00ED hodnoty (70.0-94.1% vs 65.0-76.3%) a negativn\u00ED prediktivn\u00ED hodnoty (70.0-94.1% vs 65.0-76.3%) pro gadobenate dimeglumine. Steady-state obrazy neprok\u00E1zaly lep\u0161\u00ED v\u00FDsledky pro gadofosveset. Shoda hodnotitel\u016F byla dobr\u00E1 a\u017E vynikaj\u00EDc\u00ED (gadobenate dimeglumine, kappa = 0.855;" . "10"^^ . "OBJECTIVE: This prospective multicenter intraindividual crossover study wasdesigned to compare gadobenate dimeglumine and gadofosveset trisodium at approveddoses with respect to the image quality and diagnostic performance ofcontrast-enhanced MR angiography (CE-MRA) in the detection of clinically relevantrenal artery stenosis.SUBJECTS AND METHODS: Thirty-nine subjects (17 men, 22 women; age range, 30-86years; mean 62 +/- 13.3 [SD] years) with known or suspected renovascular disease underwent a first CE-MRA examination with 0.1 mmol/kg gadobenate dimeglumine and a second examination 3-12 days later with 0.03 mmol/kg gadofosveset. IdenticalT1-weighted spoiled gradient-refocused echo coronal first-pass images wereacquired for 38 of the 39 patients. For 15 of the 38 patients, additionalsagittal or axial images or both were acquired with gadofosveset during thesteady-state phase. Thirty-four patients underwent digital subtractionangiography, which was the reference standard. Three independent blinded readers assessed source images and maximum-intensity-projection reconstructions to detectclinically relevant (> 50%) renal artery stenosis. Diagnostic performance(sensitivity, specificity, accuracy, positive and negative predictive values) wasevaluated with the McNemar and Wald tests. Matched-pair determinations ofdiagnostic preference were evaluated with Wilcoxon's signed rank test. Readeragreement was determined with kappa analysis, and safety was assessed.RESULTS: Comparison of first-pass images revealed superior sensitivity(75.7-86.5% vs 68.4-76.3%), specificity (92.1-98.6% vs 90.5-93.9%), accuracy(88.9-96.2% vs 85.9-90.3%), positive predictive value (70.0-94.1% vs 65.0-76.3%),and negative predictive value (94.0-96.6% vs 91.7-93.9%) with gadobenatedimeglumine. Significant superiority was noted for specificity (p < or = 0.02),accuracy (p < or = 0.005), and positive predictive value (p < or = 0.018).Steady-state images show"@en . "1"^^ . . . "Gadobenate Dimeglumine and Gadofosveset Trisodium for MR Angiography of the Renal Arteries: Multicenter Intraindividual"@en . "Gadobenate dimeglumine a gadofosveset trisodium p\u0159i MR angiografii ren\u00E1ln\u00EDch tepen: Multicentrick\u00E9 intrandividu\u00E1ln\u00ED srov"@cs . . "Gadobenate Dimeglumine and Gadofosveset Trisodium for MR Angiography of the Renal Arteries: Multicenter Intraindividual"@en . . "RIV/00023884:_____/10:#0004903!RIV12-MZ0-00023884" . . "[0A1599B9734E]" . "195" . . "magnetic resonance imaging, contrast agent, angiography"@en . "Gadobenate dimeglumine a gadofosveset trisodium p\u0159i MR angiografii ren\u00E1ln\u00EDch tepen: Multicentrick\u00E9 intrandividu\u00E1ln\u00ED srov" . "RIV/00023884:_____/10:#0004903" .