"L\u00E9kov\u00E9 interakce" . "RIV/00023841:_____/00:00005714!RIV/2003/MZ0/L18003/N" . "L\u00E9kov\u00E9 interakce" . . "Perl\u00EDk, Franti\u0161ek" . "2" . "715909" . "CZ - \u010Cesk\u00E1 republika" . "P(NL6066)" . "1"^^ . . . . "[FBA538B91DA2]" . "Trendy v medic\u00EDn\u011B" . "L\u00E9kov\u00E9 interakce"@cs . "This paper is composed of overall concepts of the existence and importance of drug interactions in current pharmacotherapy. There are several basic mechanisms of drug interactions and some supporting factors for their existence. Interactions manifest at the level of pharmaceutics, pharmacodynamics and pharmacokinetics. Clinically, pharmacodynamic interactions occur the most frequently. In this case, the effect of the medicament is influenced by the site of action. Basic mechanisms of pharmacokinetic interactions are summarized at the level of absorption, distribution and elimination.The most important of these are the interactions which induce or inhibit metabolic reactions. Combination of the knowledge of such mechanisms of drug interaction and the careful clinical observation of the patient can increase understanding to facilitate enhanced safety and efficacy of therapy."@en . "Drug interaktion"@en . . . . "7"^^ . "Drug interaktion"@en . . . . . "V pr\u00E1ci je pod\u00E1n p\u0159ehled v\u00FDskytu a v\u00FDznamu l\u00E9kov\u00FDch interakc\u00ED v sou\u010Dasn\u00E9 farmakoterapii. Jsou uvedeny z\u00E1kladn\u00ED mechanismy l\u00E9kov\u00FDch interakc\u00ED i podp\u016Frn\u00E9 faktory jejich vzniku. Interakce l\u00E9\u010Div se projevuj\u00ED na \u00FArovni farmaceutick\u00E9, farmakodynamick\u00E9a farmakokinetick\u00E9. V klinick\u00E9 praxi jsou velmi \u010Dast\u00E9 interakce farmakodynamick\u00E9, p\u0159i kter\u00FDch je \u00FA\u010Dinek jednoho l\u00E9\u010Diva ovlivn\u011Bn jinou l\u00E1tkou a m\u00EDst\u011B p\u016Fsoben\u00ED. Shrnuty jsou t\u00E9\u017E z\u00E1kladn\u00ED mechanismy farmakokinetick\u00FDch interakc\u00ED popsan\u00E9 p\u0159i vst\u0159eb\u00E1v\u00E1n\u00EDdistribuc\u00ED a vylu\u010Dov\u00E1n\u00ED. Zvl\u00E1\u0161t\u011B z\u00E1va\u017En\u00E9 jsou interakce, kter\u00E9 vyvol\u00E1vaj\u00ED indukci nebo inhibici metabolick\u00FDch reakc\u00ED. Znalost interak\u010Dn\u00EDch mechanism\u016F, spole\u010Dn\u011B s pe\u010Dliv\u00FDm klinick\u00FDm sledov\u00E1n\u00EDm nemocn\u00FDch, pom\u00E1h\u00E1 zv\u00FD\u0161it bezpe\u010Dnost a \u00FA\u010Dinnost l\u00E9\u010Dby." . "drug interactions;adverse drug reactions;pharmacodynamics;pharmacokinetics;pharmacotherapy"@en . "RIV/00023841:_____/00:00005714" . . . "100-106" . "2" . "L\u00E9kov\u00E9 interakce"@cs . . . . "1"^^ . .