. "[ACA3B300CB5E]" . "RIV/00023752:_____/14:43914678" . "13"^^ . . . . "CZ - \u010Cesk\u00E1 republika" . "24193" . "This literature review begins with a rationale for the development of new therapeutic approaches for the treatment of depressive disorder. In the following sections is summarized history of the ketamine\u00B4s antidepressant effect finding, its pharmacological properties and application routes. The following is an overview of the existing scientific evidence of ketamine\u00B4s efficacy in patients with unipolar and bipolar depression, suicidality and the adjuvant use in electroconvulsive therapy. Finally, the author discuss acute and chronic side effects, safety of repeated administration of ketamine and possibilities of extending the antidepressant effect. The last section summarizes recent findings on the mechanism of the antidepressant effect of ketamine on the molecular level and its effect on neuronal plasticity."@en . "4" . "\u0160\u00F3\u0161, Peter" . "Ketamine in the treatment of depressive disorder"@en . "1"^^ . "Ketamin v l\u00E9\u010Db\u011B depresivn\u00ED poruchy"@cs . "http://www.tigis.cz/images/stories/psychiatrie/2015/1-2015/sos3.pdf" . . "18" . . "RIV/00023752:_____/14:43914678!RIV15-MSM-00023752" . . . "Tento p\u0159ehled literatury za\u010D\u00EDn\u00E1 zd\u016Fvodn\u011Bn\u00EDm v\u00FDvoje nov\u00FDch terapeutick\u00FDch p\u0159\u00EDstup\u016F k l\u00E9\u010Db\u011B depresivn\u00ED poruchy. V dal\u0161\u00EDch \u010D\u00E1stech je shrnuta historie objevu antidepresivn\u00EDho p\u016Fsoben\u00ED ketaminu, jeho farmakologick\u00E9 vlastnosti a zp\u016Fsoby aplikace. N\u00E1sleduje p\u0159ehled dosavadn\u00ED v\u011Bdeck\u00E9 evidence \u00FA\u010Dinnosti ketaminu v l\u00E9\u010Db\u011B pacient\u016F s unipol\u00E1rn\u00ED a bipol\u00E1rn\u00ED depres\u00ED, ovlivn\u011Bn\u00ED suicidality a adjuvantn\u00EDho vyu\u017Eit\u00ED b\u011Bhem elektrokonvulzivn\u00ED terapie. Ke konci jsou probr\u00E1ny akutn\u00ED a chronick\u00E9 vedlej\u0161\u00ED \u00FA\u010Dinky, bezpe\u010Dnost opakovan\u00E9ho pod\u00E1v\u00E1n\u00ED ketaminu a mo\u017Enosti prodlou\u017Een\u00ED antidepresivn\u00EDho \u00FA\u010Dinku. Posledn\u00ED \u010D\u00E1st shrnuje aktu\u00E1ln\u00ED n\u00E1lezy o mechanismu antidepresivn\u00EDho \u00FA\u010Dinku ketaminu na molekul\u00E1rn\u00ED \u00FArovni a jeho vlivu na neuron\u00E1ln\u00ED plasticitu."@cs . "Ketamin v l\u00E9\u010Db\u011B depresivn\u00ED poruchy"@cs . . "Ketamin v l\u00E9\u010Db\u011B depresivn\u00ED poruchy" . "1"^^ . . "Tento p\u0159ehled literatury za\u010D\u00EDn\u00E1 zd\u016Fvodn\u011Bn\u00EDm v\u00FDvoje nov\u00FDch terapeutick\u00FDch p\u0159\u00EDstup\u016F k l\u00E9\u010Db\u011B depresivn\u00ED poruchy. V dal\u0161\u00EDch \u010D\u00E1stech je shrnuta historie objevu antidepresivn\u00EDho p\u016Fsoben\u00ED ketaminu, jeho farmakologick\u00E9 vlastnosti a zp\u016Fsoby aplikace. N\u00E1sleduje p\u0159ehled dosavadn\u00ED v\u011Bdeck\u00E9 evidence \u00FA\u010Dinnosti ketaminu v l\u00E9\u010Db\u011B pacient\u016F s unipol\u00E1rn\u00ED a bipol\u00E1rn\u00ED depres\u00ED, ovlivn\u011Bn\u00ED suicidality a adjuvantn\u00EDho vyu\u017Eit\u00ED b\u011Bhem elektrokonvulzivn\u00ED terapie. Ke konci jsou probr\u00E1ny akutn\u00ED a chronick\u00E9 vedlej\u0161\u00ED \u00FA\u010Dinky, bezpe\u010Dnost opakovan\u00E9ho pod\u00E1v\u00E1n\u00ED ketaminu a mo\u017Enosti prodlou\u017Een\u00ED antidepresivn\u00EDho \u00FA\u010Dinku. Posledn\u00ED \u010D\u00E1st shrnuje aktu\u00E1ln\u00ED n\u00E1lezy o mechanismu antidepresivn\u00EDho \u00FA\u010Dinku ketaminu na molekul\u00E1rn\u00ED \u00FArovni a jeho vlivu na neuron\u00E1ln\u00ED plasticitu." . "Ketamin v l\u00E9\u010Db\u011B depresivn\u00ED poruchy" . . "1211-7579" . . "synaptogeneze; mTOR; BDNF; ketamine; depressive disorder"@en . "P(ED2.1.00/03.0078)" . . "Psychiatrie" . . . . "Ketamine in the treatment of depressive disorder"@en . .