. . . "RIV/00023752:_____/12:43913752!RIV13-MZ0-00023752" . . "Antidepresiva - od teorie ke klinick\u00E9 praxi"@cs . . "26" . "1212-7973" . . . "122928" . "[F1270BCD97C5]" . "Fuj\u00E1kov\u00E1, Michaela" . "Antidepressants were first introduced to the market nearly 60 years ago. They were initially used to treat depression; however, their potential is currently much broader. The development of biochemical, molecular and cellular techniques to investigate their mode of action helped us to identify the etiology of many other psychopathological processes. In addition to the theoretical knowledge, the clinical usage, possible adverse effects, drug-to-drug interactions as well as indications in specific population groups are discussed in the article. specific population."@en . . "RIV/00023752:_____/12:43913752" . . "CZ - \u010Cesk\u00E1 republika" . "Antidepressants - from theory to clinical use"@en . . "1" . "Antidepresiva - od teorie ke klinick\u00E9 praxi" . "Kope\u010Dek, Miloslav" . "http://www.klinickafarmakologie.cz/artkey/far-201201-0006_Antidepresiva_8211_od_teorie_ke_klinicke_praxi.php" . . "Antidepressants - from theory to clinical use"@en . . "Antidepresiva - od teorie ke klinick\u00E9 praxi"@cs . . "Klinick\u00E1 farmakologie a farmacie" . "P(1M0517), P(NS10374), P(NS10375), P(VG20122015075), P(VG20122015080), S, Z(MZ0PCP2005)" . "Antidepresiva byla uvedena na trh p\u0159ed 60 lety. L\u00E9\u010Debn\u00E9 indikace zpo\u010D\u00E1tku zahrnovaly pouze depresivn\u00ED poruchu, jejich potenci\u00E1l je v\u0161ak mnohem \u0161ir\u0161\u00ED. D\u00EDky rozvoji biochemick\u00FDch a molekul\u00E1rn\u00EDch metod se v posledn\u00ED dob\u011B da\u0159\u00ED rozpoznat nov\u00E9 mechanizmy \u00FA\u010Dinku, stejn\u011B jako se p\u0159ibl\u00ED\u017Eit k etiologii psychopatologick\u00FDch proces\u016F. Krom\u011B teoretick\u00FDch poznatk\u016F se \u010Dl\u00E1nek v\u011Bnuje klinick\u00E9mu pou\u017Eit\u00ED antidepresiv, mo\u017En\u00FDm ne\u017E\u00E1douc\u00EDm \u00FA\u010Dink\u016Fm, interakc\u00EDm, jako\u017E i pod\u00E1v\u00E1n\u00EDm antidepresiv u specifick\u00FDch populac\u00ED."@cs . . . "Antidepresiva byla uvedena na trh p\u0159ed 60 lety. L\u00E9\u010Debn\u00E9 indikace zpo\u010D\u00E1tku zahrnovaly pouze depresivn\u00ED poruchu, jejich potenci\u00E1l je v\u0161ak mnohem \u0161ir\u0161\u00ED. D\u00EDky rozvoji biochemick\u00FDch a molekul\u00E1rn\u00EDch metod se v posledn\u00ED dob\u011B da\u0159\u00ED rozpoznat nov\u00E9 mechanizmy \u00FA\u010Dinku, stejn\u011B jako se p\u0159ibl\u00ED\u017Eit k etiologii psychopatologick\u00FDch proces\u016F. Krom\u011B teoretick\u00FDch poznatk\u016F se \u010Dl\u00E1nek v\u011Bnuje klinick\u00E9mu pou\u017Eit\u00ED antidepresiv, mo\u017En\u00FDm ne\u017E\u00E1douc\u00EDm \u00FA\u010Dink\u016Fm, interakc\u00EDm, jako\u017E i pod\u00E1v\u00E1n\u00EDm antidepresiv u specifick\u00FDch populac\u00ED." . . "specific population; overdose and discontinuation; adverse effects; interactions and combinations; mechanism of action; antidepressants"@en . . . . . "8"^^ . . "Antidepresiva - od teorie ke klinick\u00E9 praxi" . "2"^^ . . . . . "2"^^ . . .