. . . . . . "Ibrahim, I." . . "Neuroendocrinology Letters" . "OBJECTIVE: The aim of the study was to assess structural changes in gray matter (GM) volume and fractional anisotropy (FA) in patients with Alzheimer`s disease (AD) compared to control subjects using Voxel-Based Morphometry (VBM). Fractional anisotropy in the corpus callosum of both groups was also calculated using ROI analysis. METHODS: Twenty-one patients and twenty-three control subjects underwent MRI examination using T1-weighted 3D MPRAGE sequence and diffusion spin-echo echo-planar imaging sequence in six directions. Structural MRI analyses for GM volume and FA were performed using an optimized VBM protocol implemented in SPM5. The influence of age and Mini-Mental State Examination (MMSE) was dealt with multiple regression analysis either for the whole group or for AD patients and controls separately. RESULTS: Patients showed significant reduction of GM volume mainly in the temporal lobes. In AD patients, no correlation was observed between GM volume and age or MMSE. FA was reduced in AD patient"@en . "[0A6A6A888546]" . "\u0158\u00EDpov\u00E1, Daniela" . . "7"^^ . . . . "Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease" . "Alzheimer`s disease; voxel-based morphometry; diffusion tensor imaging; MRI; white matter; grey matter; fractional anisotropy; age"@en . "H\u00E1jek, M." . . "OBJECTIVE: The aim of the study was to assess structural changes in gray matter (GM) volume and fractional anisotropy (FA) in patients with Alzheimer`s disease (AD) compared to control subjects using Voxel-Based Morphometry (VBM). Fractional anisotropy in the corpus callosum of both groups was also calculated using ROI analysis. METHODS: Twenty-one patients and twenty-three control subjects underwent MRI examination using T1-weighted 3D MPRAGE sequence and diffusion spin-echo echo-planar imaging sequence in six directions. Structural MRI analyses for GM volume and FA were performed using an optimized VBM protocol implemented in SPM5. The influence of age and Mini-Mental State Examination (MMSE) was dealt with multiple regression analysis either for the whole group or for AD patients and controls separately. RESULTS: Patients showed significant reduction of GM volume mainly in the temporal lobes. In AD patients, no correlation was observed between GM volume and age or MMSE. FA was reduced in AD patient" . . . "SE - \u0160v\u00E9dsk\u00E9 kr\u00E1lovstv\u00ED" . . "Brunovsk\u00FD, Martin" . "Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease" . . "Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease"@en . "307534" . "000265426800011" . . . "0172-780X" . . . "Tint\u011Bra, Jaroslav" . . . "Barto\u0161, Ale\u0161" . . "7"^^ . "P(1A8600), P(1M0517), P(NR8792), S, Z(MZ0IKEM2005), Z(MZ0PCP2005)" . . "30" . . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . "1" . "Combination of voxel based morphometry and diffusion tensor imaging in patients with Alzheimer`s disease"@en . "RIV/00023752:_____/09:00000942" . . . . . "4"^^ . "RIV/00023752:_____/09:00000942!RIV10-MZ0-00023752" .