"Genetick\u00E1 podstata Alzheimerovy nemoci a mo\u017Enost jej\u00ED predikce"@cs . . . "12" . "\u0160\u0165astn\u00FD, Franti\u0161ek" . "RIV/00023752:_____/08:00000916!RIV09-MZ0-00023752" . "[0F8E662FD2DE]" . "Psychiatrie" . "7"^^ . "Genetic principle of Alzheimer`s disease and possibility of its prediction"@en . "1"^^ . "RIV/00023752:_____/08:00000916" . . . . . "CZ - \u010Cesk\u00E1 republika" . . "Alzheimer\u00B4s disease (AD) is the most common age-related neurodegenerative disorder and the most frequent cause of dementia during aging. Most forms of AD are idiopathic, with the onset of symptoms after 65 years of age, but a small part of patients exhibit familial form of dementia (FAD) with clinical symptoms appearing before age 55. Genetic progress in the field of AD revealed three genes (APP, PSEN1 and PSEN2) responsible for the autosomal-dominant early onset form of FAD and one late-onset candidate gene (APOE) for idiopathic AD. However, strong evidence exists suggesting the presence of additional AD genes for both forms of the disease. Besides genes for the familial and idiopathic forms, also MAPT gene for tau protein is involved in the phenomenology of AD, being related to frontotemporal dementia with the onset around age 60. This minireview is focused at recent genetic researches allowing new strategies in the prediction of AD in spite of complexity and genetic heterogeneity of this devastatin"@en . "Alzheimerova nemoc (AD) pat\u0159\u00ED mezi na v\u011Bku z\u00E1visl\u00E9 neurodegenerativn\u00ED onemocn\u011Bn\u00ED a sou\u010Dasn\u011B nej\u010Dast\u011Bj\u0161\u00ED p\u0159\u00ED\u010Dinu demence u st\u00E1rnouc\u00EDch osob. Nej\u010Dast\u011Bj\u0161\u00ED podobu prim\u00E1rn\u00ED demence p\u0159edstavuj\u00ED idiopatick\u00E9 formy AD, jejich\u017E p\u0159\u00EDznaky se objevuj\u00ED u osob po 65. roce v\u011Bku, zat\u00EDmco mal\u00E1 \u010D\u00E1st nemocn\u00FDch trp\u00ED famili\u00E1rn\u00ED formou t\u00E9to poruchy (FAD), s n\u00E1stupem klinick\u00FDch p\u0159\u00EDznak\u016F p\u0159ed 55. rokem v\u011Bku. Pokrok v oblasti lidsk\u00E9 genetiky vztahuj\u00EDc\u00ED se k AD p\u0159inesl objev 3 gen\u016F (APP, PSEN1 a PSEN2), kter\u00E9 odpov\u00EDdaj\u00ED za autozom\u00E1ln\u011B dominantn\u00ED formu FAD v \u010Dasn\u00FDm n\u00E1stupem. Av\u0161ak v\u00FDzkum odhalil jen jedin\u00FD v\u00FDznamn\u00FD kandid\u00E1tn\u00ED gen (APOE) pro idiopatickou formu AD. V sou\u010Dasnosti existuj\u00ED i v\u00FDznamn\u00E9 doklady o existenci dal\u0161\u00EDch gen\u016F maj\u00EDc\u00EDch vztah k ob\u011Bma hlavn\u00EDm form\u00E1m AD. Krom\u011B ji\u017E zm\u00EDn\u011Bn\u00FDch gen\u016F existuje i gen MAPT pro tau protein, kter\u00FD se pod\u00EDl\u00ED na fenomenologii AD se vztahem k frontotempor\u00E1ln\u00ED demenci se za\u010D\u00EDnaj\u00EDc\u00EDmi projevy kolem 60. roku v\u011Bku. Tento kr\u00E1tk\u00FD p\u0159ehled shrnuje p\u0159edev\u0161\u00EDm v\u00FDsledky ned\u00E1vn\u00E9ho genetick\u00E9ho v\u00FDzkumu, kte"@cs . . "Genetick\u00E1 podstata Alzheimerovy nemoci a mo\u017Enost jej\u00ED predikce" . . . . "Genetick\u00E1 podstata Alzheimerovy nemoci a mo\u017Enost jej\u00ED predikce" . . "N, S" . . . . . "Genetic principle of Alzheimer`s disease and possibility of its prediction"@en . "Genetick\u00E1 podstata Alzheimerovy nemoci a mo\u017Enost jej\u00ED predikce"@cs . "369142" . . . . . "1211-7579" . . "Alzheimerova nemoc (AD) pat\u0159\u00ED mezi na v\u011Bku z\u00E1visl\u00E9 neurodegenerativn\u00ED onemocn\u011Bn\u00ED a sou\u010Dasn\u011B nej\u010Dast\u011Bj\u0161\u00ED p\u0159\u00ED\u010Dinu demence u st\u00E1rnouc\u00EDch osob. Nej\u010Dast\u011Bj\u0161\u00ED podobu prim\u00E1rn\u00ED demence p\u0159edstavuj\u00ED idiopatick\u00E9 formy AD, jejich\u017E p\u0159\u00EDznaky se objevuj\u00ED u osob po 65. roce v\u011Bku, zat\u00EDmco mal\u00E1 \u010D\u00E1st nemocn\u00FDch trp\u00ED famili\u00E1rn\u00ED formou t\u00E9to poruchy (FAD), s n\u00E1stupem klinick\u00FDch p\u0159\u00EDznak\u016F p\u0159ed 55. rokem v\u011Bku. Pokrok v oblasti lidsk\u00E9 genetiky vztahuj\u00EDc\u00ED se k AD p\u0159inesl objev 3 gen\u016F (APP, PSEN1 a PSEN2), kter\u00E9 odpov\u00EDdaj\u00ED za autozom\u00E1ln\u011B dominantn\u00ED formu FAD v \u010Dasn\u00FDm n\u00E1stupem. Av\u0161ak v\u00FDzkum odhalil jen jedin\u00FD v\u00FDznamn\u00FD kandid\u00E1tn\u00ED gen (APOE) pro idiopatickou formu AD. V sou\u010Dasnosti existuj\u00ED i v\u00FDznamn\u00E9 doklady o existenci dal\u0161\u00EDch gen\u016F maj\u00EDc\u00EDch vztah k ob\u011Bma hlavn\u00EDm form\u00E1m AD. Krom\u011B ji\u017E zm\u00EDn\u011Bn\u00FDch gen\u016F existuje i gen MAPT pro tau protein, kter\u00FD se pod\u00EDl\u00ED na fenomenologii AD se vztahem k frontotempor\u00E1ln\u00ED demenci se za\u010D\u00EDnaj\u00EDc\u00EDmi projevy kolem 60. roku v\u011Bku. Tento kr\u00E1tk\u00FD p\u0159ehled shrnuje p\u0159edev\u0161\u00EDm v\u00FDsledky ned\u00E1vn\u00E9ho genetick\u00E9ho v\u00FDzkumu, kte" . "4" . . . "Alzheimer`s disease; dementia; amyloid precursor protein; amyloid peptide; presenilin; gama-secretase; tau protein; apolipoprotein E; risk genes; glutamate receptors; genetic prediction"@en . "1"^^ .