"RIV/00023752:_____/07:00000780" . "Inhibitory cholinester\u00E1z v l\u00E9\u010Db\u011B Alzheimerovy nemoci" . . "1213-1814" . . "RIV/00023752:_____/07:00000780!RIV08-MZ0-00023752" . . "426674" . "[99D228EAEC69]" . "Hlavn\u00EDm c\u00EDlem sou\u010Dasn\u00E9 symptomatick\u00E9 l\u00E9\u010Dby Alzheimerovy choroby (AD) z\u016Fst\u00E1v\u00E1 odd\u00E1len\u00ED progrese symptom\u016F nemoci zv\u00FD\u0161en\u00EDm cholinergn\u00ED neurotransmise pomoc\u00ED inhibitor\u016F cholinester\u00E1z (IChE). D\u016Fle\u017Eit\u00FDmi ukazateli okam\u017Eit\u00E9 i dlouhodob\u00E9 \u00FA\u010Dinnosti, bezpe\u010Dnosti a sn\u00E1\u0161enlivosti r\u016Fzn\u00FDch IChE je specifita jejich inhibi\u010Dn\u00ED aktivity, selektivita v\u016F\u010Di AD - relevantn\u00EDm molekul\u00E1rn\u00EDm izoform\u00E1m cholinester\u00E1z, selektivita v\u016F\u010Di mozku a perifern\u00ED tk\u00E1ni a v nemal\u00E9 m\u00ED\u0159e i jejich farmakokinetick\u00FD profil. \u010Cl\u00E1nek p\u0159in\u00E1\u0161\u00ED stru\u010Dnou deskripci jednotliv\u00FDch typ\u016F cholinester\u00E1z, jejich funkc\u00ED a mo\u017Enostech jejich inhibice. V souvislosti s l\u00E9\u010Dbou IChE se \u010Dl\u00E1nek zam\u011B\u0159uje na projevy cholinergn\u00EDho deficitu z hlediska kognitivn\u00EDch funkc\u00ED a tak\u00E9 na rozd\u00EDln\u00E9 profily tolerance a spektra ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F jednotliv\u00FDch IChE, a to z hlediska akutn\u00ED i dlouhodob\u00E9 l\u00E9\u010Dby."@cs . . "1"^^ . "1"^^ . "P(1A8600)" . "Hlavn\u00EDm c\u00EDlem sou\u010Dasn\u00E9 symptomatick\u00E9 l\u00E9\u010Dby Alzheimerovy choroby (AD) z\u016Fst\u00E1v\u00E1 odd\u00E1len\u00ED progrese symptom\u016F nemoci zv\u00FD\u0161en\u00EDm cholinergn\u00ED neurotransmise pomoc\u00ED inhibitor\u016F cholinester\u00E1z (IChE). D\u016Fle\u017Eit\u00FDmi ukazateli okam\u017Eit\u00E9 i dlouhodob\u00E9 \u00FA\u010Dinnosti, bezpe\u010Dnosti a sn\u00E1\u0161enlivosti r\u016Fzn\u00FDch IChE je specifita jejich inhibi\u010Dn\u00ED aktivity, selektivita v\u016F\u010Di AD - relevantn\u00EDm molekul\u00E1rn\u00EDm izoform\u00E1m cholinester\u00E1z, selektivita v\u016F\u010Di mozku a perifern\u00ED tk\u00E1ni a v nemal\u00E9 m\u00ED\u0159e i jejich farmakokinetick\u00FD profil. \u010Cl\u00E1nek p\u0159in\u00E1\u0161\u00ED stru\u010Dnou deskripci jednotliv\u00FDch typ\u016F cholinester\u00E1z, jejich funkc\u00ED a mo\u017Enostech jejich inhibice. V souvislosti s l\u00E9\u010Dbou IChE se \u010Dl\u00E1nek zam\u011B\u0159uje na projevy cholinergn\u00EDho deficitu z hlediska kognitivn\u00EDch funkc\u00ED a tak\u00E9 na rozd\u00EDln\u00E9 profily tolerance a spektra ne\u017E\u00E1douc\u00EDch \u00FA\u010Dink\u016F jednotliv\u00FDch IChE, a to z hlediska akutn\u00ED i dlouhodob\u00E9 l\u00E9\u010Dby." . "CZ - \u010Cesk\u00E1 republika" . "Inhibitory cholinester\u00E1z v l\u00E9\u010Db\u011B Alzheimerovy nemoci"@cs . "Inhibitory cholinester\u00E1z v l\u00E9\u010Db\u011B Alzheimerovy nemoci"@cs . . . "Neurologie pro praxi" . "Alzheimer`s disease; cholinesterase inhibitors; treatment; side effects"@en . "112-117" . . . . "Cholinesterase inhibitors in treatment of Alzheimer`s disease"@en . . "6"^^ . "8" . . . "Brunovsk\u00FD, Martin" . . . "2" . "Inhibitory cholinester\u00E1z v l\u00E9\u010Db\u011B Alzheimerovy nemoci" . . "Cholinesterase inhibitors in treatment of Alzheimer`s disease"@en . "The delay of symptoms progression by inhibition of brain acetylcholinesterase (AChE) is the major therapeutic target of ChE-I treatment strategies for Alzheimer's disease (AD). The specificity of ChE inhibitory activity, up-regulation of AChE activity and changes in the composition of AChE molecular forms over time, selectivity for AD-relevant ChE molecular forms, brain vs. peripheral selectivity, and pharmacokinetic profile may be important determinants of the acute and long-term efficacy, safety and tolerability profiles of the different ChE-Is."@en . .