. "Increased sensitivity to the acute effects of MDMA (%22ecstasy%22) in female rats"@en . "RIV/00023752:_____/05:00000491!RIV06-MZ0-00023752" . "Behavior\u00E1ln\u00ED \u00FA\u010Dinky l\u00E1tky 3,4 metylendioxymetamfetaminu (MDMA, ext\u00E1ze) jsou pom\u011Brn\u011B dob\u0159e pops\u00E1ny u lid\u00ED a stejn\u011B tak i u zv\u00ED\u0159at. M\u00E1lo je ale zn\u00E1mo o pohlavn\u00EDch rozd\u00EDlech v \u00FA\u010Dinc\u00EDch MDMA. C\u00EDlem na\u0161\u00ED studie bylo studium pohlavn\u00EDch rozd\u00EDl\u016F ve stimula\u010Dn\u00EDch \u00FA\u010Dinc\u00EDch MDMA (2,5; 5,0 a 10,0 mg/kg (s.c.)) u samc\u016F a samic potkan\u016F kmene Wistar. Pomoc\u00ED 3 r\u016Fzn\u00FDch behavior\u00E1ln\u00EDch metod (aktivitn\u00ED klec, test otev\u0159en\u00E9ho pole a test vyv\u00FD\u0161en\u00E9ho k\u0159\u00ED\u017Eov\u00E9ho bludi\u0161t\u011B) jsme sledovali rozd\u00EDln\u00E9 parametry spont\u00E1nn\u00EDho chov\u00E1n\u00ED. V aktivitn\u00ED kleci jsme 30 minut po pod\u00E1n\u00ED MDMA hodnotili horizont\u00E1ln\u00ED a vertik\u00E1ln\u00ED lokomo\u010Dn\u00ED aktivitu po dobu 3 minut. V testu otev\u0159en\u00E9ho pole byli potkani um\u00EDst\u011Bni do ar\u00E9ny 15 minut po pod\u00E1n\u00ED drogy a lokomo\u010Dn\u00ED aktivitu jsme registrovali po dobu 30 minut. A nakonec, v testu vyv\u00FD\u0161en\u00E9ho k\u0159\u00ED\u017Eov\u00E9ho bludi\u0161ti byli potkani aplikov\u00E1ni MDMA 30 minut p\u0159ed za\u010D\u00E1tkem m\u011B\u0159en\u00ED a n\u00E1sledn\u011B byli v bludi\u0161ti hodnoceni po dobu 5 minut. V na\u0161ich experimentech jsme pozorovali, \u017Ee MDMA p\u016Fsob\u00ED v z\u00E1vislosti na d\u00E1vce zv\u00FD\u0161"@cs . "4"^^ . "[018BDAA9A385]" . . . . "0031-9384" . "Increased sensitivity to the acute effects of MDMA (%22ecstasy%22) in female rats"@cs . "Increased sensitivity to the acute effects of MDMA (%22ecstasy%22) in female rats"@en . "Buben\u00EDkov\u00E1, V\u011Bra" . . "Votava, M." . "P\u00E1len\u00ED\u010Dek, Tom\u00E1\u0161" . "Increased sensitivity to the acute effects of MDMA (%22ecstasy%22) in female rats"@cs . "RIV/00023752:_____/05:00000491" . . "Behavioral effects of T3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are relatively well described in humans as well as in animals. However, little is known about gender differences to the effects of MDMA. The aim of our study was to evaluate gender differences in stimulant effects of MDMA (2.5, 5.0, and 10.0 mg/kg subcutaneously (s.c.)) in male and female Wistar rats. We have used three behavioral methods (activity cage, open field, and elevated plus-maze) each describing a different pattern of spontaneous behavior. In the activity cage, 30 min after the MDMA administration, horizontal and vertical locomotor activities were registered for a period of 3 min. In the open field test rats were placed into an arena 15 min after drug treatment and locomotor activity was registered for a period of 30 min. Finally, in the elevated plus-maze test, rats were given MDMA 30 min prior to measurements and subsequently they were tested in the maze for a period of 5 min. In our experiments we observed a dose-dep" . . "Behavioral effects of T3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are relatively well described in humans as well as in animals. However, little is known about gender differences to the effects of MDMA. The aim of our study was to evaluate gender differences in stimulant effects of MDMA (2.5, 5.0, and 10.0 mg/kg subcutaneously (s.c.)) in male and female Wistar rats. We have used three behavioral methods (activity cage, open field, and elevated plus-maze) each describing a different pattern of spontaneous behavior. In the activity cage, 30 min after the MDMA administration, horizontal and vertical locomotor activities were registered for a period of 3 min. In the open field test rats were placed into an arena 15 min after drug treatment and locomotor activity was registered for a period of 30 min. Finally, in the elevated plus-maze test, rats were given MDMA 30 min prior to measurements and subsequently they were tested in the maze for a period of 5 min. In our experiments we observed a dose-dep"@en . . "-" . "86" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . . "524528" . . . "3,4-methylenedioxymethamphetamine; MDMA; sensistivity; sex differences; rats; behavior; activity cage; open field; locomotion"@en . . . . "8"^^ . . "Physiology & Behavior" . . . "P(NJ7636)" . . "Increased sensitivity to the acute effects of MDMA (%22ecstasy%22) in female rats" . . . "Increased sensitivity to the acute effects of MDMA (%22ecstasy%22) in female rats" . . . "3"^^ . "546-553" . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . .