"P(NJ7636)" . "[2230A78A95CB]" . "3"^^ . "\u00DA\u010Dinky MDMA, LSD a psilocinu na lokomoci potkana" . "Adiktologie" . "Introduction: Abuse of designer drugs by young people has recently become a highly topical phenomenon. These drugs mainly consist of phenylethylamine and tryptamine derivatives. These are substance with stimulant, entactogenic and hallucinogenic effects. Certainly, 3,4 - methylenedioxymethamphetamine (MDMA, ecstasy), N,N-diethyllysergamide (LSD) and 4-hydroxy-N,N-dimethyltryptamine (Psilocin) appear most frequently. These drugs predominantly stimulate serotonergic system of the brain. In our experiments, we have compared behavioral changes in rats induced by acute administration of these three substance. Metod: Wistar rats b.w. 200-250 g (Kon\u00E1rovice) were administered several doses of MDMA (2.5, 5.0 and 10.0mg/kg), LSD (5, 50 and 200 ug/kg) or Psilocin (0.25 and 1.0 mg/kg). Subsequently , the locomotor activity of the rats in the open field was registered by the automatic videotracking system Ethovision Color Pro v. 3.1.1. (Noldus). Results: The MDMA dose dependently prolonged the rat trajectory. On"@en . "\u00DAvod: Problematika u\u017E\u00EDv\u00E1n\u00ED tzv. %22designer drugs%22 mlad\u00FDmi lidmi je v posledn\u00ED dob\u011B st\u00E1le aktu\u00E1ln\u011Bj\u0161\u00EDm t\u00E9matem. Mezi tyto l\u00E1tky pat\u0159\u00ED zejm\u00E9na deriv\u00E1ty fenyletylaminu a deriv\u00E1ty tryptaminu, l\u00E1tky s \u00FA\u010Dinky stimula\u010Dn\u00EDmi, entaktogenn\u00EDmi a halucinogenn\u00EDmi. Mezi nejroz\u0161\u00ED\u0159en\u011Bj\u0161\u00ED z t\u011Bchto drog dnes bezpochyby pat\u0159\u00ED 3,4 - metylendioxymetamfetamin (MDMA, ext\u00E1ze), N,N-dietylamid kyseliny lysergov\u00E9 (LSD) a 4-hydroxy-tryptamin (psilocin). Jedn\u00E1 se o l\u00E1tky stimuluj\u00EDc\u00ED p\u0159edev\u0161\u00EDm serotonergn\u00ED syst\u00E9m. V na\u0161ich experimentech jsme se zam\u011B\u0159ili na srovn\u00E1n\u00ED behavior\u00E1ln\u00EDch zm\u011Bn u potkan\u016F po akutn\u00EDm pod\u00E1n\u00ED t\u011Bchto t\u0159\u00ED l\u00E1tek. Metody: Potkan\u016Fm kmene Wistar o hmotnosti 200-250g (Kon\u00E1rovice) jsme aplikovali r\u016Fzn\u00E9 d\u00E1vky MDMA (2,5; 5,0 a 10,0 mg/kg), LSD (5; 50 a 200 #g/kg) nebo psilocinu (0,25 a 1,0 mg/kg). N\u00E1sledn\u011B, pomoc\u00ED automatick\u00E9ho video-registra\u010Dn\u00EDho syst\u00E9mu Ethovision color Pro v.3.1.1. (Noldus), jsme hodnotili lokomoci potkan\u016F v otev\u0159en\u00E9m poli. V\u00FDsledky: Lokomoce potkan\u016F byla v\u00FDznamn\u011B ovlivn\u011Bna pod\u00E1n\u00EDm MDMA a psil" . "Buben\u00EDkov\u00E1, V\u011Bra" . . "\u00DA\u010Dinky MDMA, LSD a psilocinu na lokomoci potkana"@cs . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . . "\u00DAvod: Problematika u\u017E\u00EDv\u00E1n\u00ED tzv. %22designer drugs%22 mlad\u00FDmi lidmi je v posledn\u00ED dob\u011B st\u00E1le aktu\u00E1ln\u011Bj\u0161\u00EDm t\u00E9matem. Mezi tyto l\u00E1tky pat\u0159\u00ED zejm\u00E9na deriv\u00E1ty fenyletylaminu a deriv\u00E1ty tryptaminu, l\u00E1tky s \u00FA\u010Dinky stimula\u010Dn\u00EDmi, entaktogenn\u00EDmi a halucinogenn\u00EDmi. Mezi nejroz\u0161\u00ED\u0159en\u011Bj\u0161\u00ED z t\u011Bchto drog dnes bezpochyby pat\u0159\u00ED 3,4 - metylendioxymetamfetamin (MDMA, ext\u00E1ze), N,N-dietylamid kyseliny lysergov\u00E9 (LSD) a 4-hydroxy-tryptamin (psilocin). Jedn\u00E1 se o l\u00E1tky stimuluj\u00EDc\u00ED p\u0159edev\u0161\u00EDm serotonergn\u00ED syst\u00E9m. V na\u0161ich experimentech jsme se zam\u011B\u0159ili na srovn\u00E1n\u00ED behavior\u00E1ln\u00EDch zm\u011Bn u potkan\u016F po akutn\u00EDm pod\u00E1n\u00ED t\u011Bchto t\u0159\u00ED l\u00E1tek. Metody: Potkan\u016Fm kmene Wistar o hmotnosti 200-250g (Kon\u00E1rovice) jsme aplikovali r\u016Fzn\u00E9 d\u00E1vky MDMA (2,5; 5,0 a 10,0 mg/kg), LSD (5; 50 a 200 #g/kg) nebo psilocinu (0,25 a 1,0 mg/kg). N\u00E1sledn\u011B, pomoc\u00ED automatick\u00E9ho video-registra\u010Dn\u00EDho syst\u00E9mu Ethovision color Pro v.3.1.1. (Noldus), jsme hodnotili lokomoci potkan\u016F v otev\u0159en\u00E9m poli. V\u00FDsledky: Lokomoce potkan\u016F byla v\u00FDznamn\u011B ovlivn\u011Bna pod\u00E1n\u00EDm MDMA a psil"@cs . . . "Votava, M." . . . "P\u00E1len\u00ED\u010Dek, Tom\u00E1\u0161" . "RIV/00023752:_____/05:00000490" . . . "MDMA (3,4-methylenedioxymethamphetamine); LSD (N,N-diethyllysergamide); Psilocin (4-hydroxy-N,N-dimethyltryptamine); serotonin; locomotion; rats"@en . "\u00DA\u010Dinky MDMA, LSD a psilocinu na lokomoci potkana"@cs . . . . "10"^^ . "Effects of MDMA, LSD and Psilocin on Locomotion in Rats"@en . "RIV/00023752:_____/05:00000490!RIV06-MZ0-00023752" . "121-130" . "5" . . . . . . . "CZ - \u010Cesk\u00E1 republika" . . "547648" . . "\u00DA\u010Dinky MDMA, LSD a psilocinu na lokomoci potkana" . "Effects of MDMA, LSD and Psilocin on Locomotion in Rats"@en . . "2" . . . "1213-3841" . . "4"^^ .