. . . "schizophrenia; prediction; genetic studies; neuroimaging; neuroendocrine tests"@en . . "Recently, psychiatry has become an evidence-based field of medicine. However, there is a lack of reliable predictions of risk of onset, course, and outcome for major psychiatric disorders, e.g. schizophrenia. Available prediction models in psychiatry are tautological, heuristic, logical, and irrelevant. Logical models of prediction in schizophrenia are based on genetic, neuroimaging (structural and functional), and neuroendocrine studies. Genetic research searches the causes of illness and pharmacogenetic predictors of treatment response. There are numerous studies of candidate gene encoding COMT polymorphism, or pharmacogenetics of response to clozapine. Neuroanatomical and functional abnormalities are generally associated with unfavorable course, outcome and treatment failure. Neuroendocrine studies measure directly or indirectly, using challenge tests, functional state of neurotransmitter systems. Results of d-fenfluramine challenge test investigating relationship between 5-HT system reactivity and"@en . "531383" . . "Mo\u017Enosti logick\u00E9 predikce schizofrenie"@cs . "1211-7579" . . "Models of logical prediction in schizophrenia"@en . . "Models of logical prediction in schizophrenia"@en . . . "RIV/00023752:_____/05:00000486!RIV06-MZ0-00023752" . "CZ - \u010Cesk\u00E1 republika" . "Psychiatrie posledn\u00EDch let se st\u00E1v\u00E1 medic\u00EDnsk\u00FDm oborem zalo\u017Een\u00FDm na d\u016Fkazech. St\u00E1le se n\u00E1m v\u0161ak nedost\u00E1v\u00E1 spolehliv\u00FDch mo\u017Enost\u00ED predikce, kter\u00E9 by n\u00E1m pomohly p\u0159edpov\u00EDdat riziko vzniku, pr\u016Fb\u011Bh a v\u00FDsledky l\u00E9\u010Dby u z\u00E1va\u017En\u00FDch du\u0161evn\u00EDch nemoc\u00ED, jako je schizofrenie St\u00E1vaj\u00EDc\u00ED modely predikce v psychiatrii lze rozd\u011Blit na modely tautologick\u00E9, heuristick\u00E9, irelevantn\u00ED a logick\u00E9. Logick\u00E9 modely predikce schizofrenie se soust\u0159e\u010Fuj\u00ED na studie genetick\u00E9, zobrazovac\u00EDch metod (morfologick\u00E9 a funk\u010Dn\u00ED) a neuroendokrinn\u00ED testy. Genetick\u00E9 studie hledaj\u00ED zejm\u00E9na p\u0159\u00ED\u010Diny onemocn\u011Bn\u00ED a farmakogenetick\u00E9 prediktory odpov\u011Bdi na l\u00E9\u010Dbu. Jedn\u00EDm z kandid\u00E1tsk\u00FDch gen\u016F je gen pro COMT s dob\u0159e zn\u00E1m\u00FDm polymorfizmem, popsan\u00E1 je tak\u00E9 geneticky podm\u00EDn\u011Bn\u00E1 terapeutick\u00E1 odpov\u011B\u010F na clozapin. Struktur\u00E1ln\u00ED a funk\u010Dn\u00ED abnormity jsou obvykle spojov\u00E1ny s hor\u0161\u00EDm pr\u016Fb\u011Bhem a nep\u0159\u00EDznivou odpov\u011Bd\u00ED na l\u00E9\u010Dbu. Neuroendokrinn\u00ED studie sleduj\u00ED p\u0159\u00EDmo \u010Di nep\u0159\u00EDmo pomoc\u00ED stimula\u010Dn\u00EDch test\u016F funk\u010Dn\u00ED stav neurotransmiterov\u00FDch syst\u00E9m\u016F. P\u0159\u00EDkladem jsou prezentovan\u00E9 v\u00FD"@cs . "Mo\u017Enosti logick\u00E9 predikce schizofrenie" . "Mo\u017Enosti logick\u00E9 predikce schizofrenie"@cs . "9" . "14-22" . . . . . . . "1" . "P(NF7571)" . "Mohr, Pavel" . "1"^^ . . "9"^^ . . "1"^^ . "Mo\u017Enosti logick\u00E9 predikce schizofrenie" . "RIV/00023752:_____/05:00000486" . "[FD52F1EE5AD4]" . "Psychiatrie" . "Psychiatrie posledn\u00EDch let se st\u00E1v\u00E1 medic\u00EDnsk\u00FDm oborem zalo\u017Een\u00FDm na d\u016Fkazech. St\u00E1le se n\u00E1m v\u0161ak nedost\u00E1v\u00E1 spolehliv\u00FDch mo\u017Enost\u00ED predikce, kter\u00E9 by n\u00E1m pomohly p\u0159edpov\u00EDdat riziko vzniku, pr\u016Fb\u011Bh a v\u00FDsledky l\u00E9\u010Dby u z\u00E1va\u017En\u00FDch du\u0161evn\u00EDch nemoc\u00ED, jako je schizofrenie St\u00E1vaj\u00EDc\u00ED modely predikce v psychiatrii lze rozd\u011Blit na modely tautologick\u00E9, heuristick\u00E9, irelevantn\u00ED a logick\u00E9. Logick\u00E9 modely predikce schizofrenie se soust\u0159e\u010Fuj\u00ED na studie genetick\u00E9, zobrazovac\u00EDch metod (morfologick\u00E9 a funk\u010Dn\u00ED) a neuroendokrinn\u00ED testy. Genetick\u00E9 studie hledaj\u00ED zejm\u00E9na p\u0159\u00ED\u010Diny onemocn\u011Bn\u00ED a farmakogenetick\u00E9 prediktory odpov\u011Bdi na l\u00E9\u010Dbu. Jedn\u00EDm z kandid\u00E1tsk\u00FDch gen\u016F je gen pro COMT s dob\u0159e zn\u00E1m\u00FDm polymorfizmem, popsan\u00E1 je tak\u00E9 geneticky podm\u00EDn\u011Bn\u00E1 terapeutick\u00E1 odpov\u011B\u010F na clozapin. Struktur\u00E1ln\u00ED a funk\u010Dn\u00ED abnormity jsou obvykle spojov\u00E1ny s hor\u0161\u00EDm pr\u016Fb\u011Bhem a nep\u0159\u00EDznivou odpov\u011Bd\u00ED na l\u00E9\u010Dbu. Neuroendokrinn\u00ED studie sleduj\u00ED p\u0159\u00EDmo \u010Di nep\u0159\u00EDmo pomoc\u00ED stimula\u010Dn\u00EDch test\u016F funk\u010Dn\u00ED stav neurotransmiterov\u00FDch syst\u00E9m\u016F. P\u0159\u00EDkladem jsou prezentovan\u00E9 v\u00FD" .