"Dockery, Colleen Anne" . "Votava, M." . . "Dockery, Colleen Anne" . . "The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating"@cs . "P\u00E1len\u00ED\u010Dek, Tom\u00E1\u0161" . . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . "The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating"@en . "80" . "591-596" . "Dizocilpine (MK-801; 0,3 mg/kg i.p.) - induced disruption in prepulse inhibition of the acoustic startle response (PPI) can be preferentially restored by %22atypical%22 antipsychotics. In contrast, some finding indicate that not all of the %22atypical%22 antipsychotics, such as clozapine and risperidone, are effective in restoring the NMDA antagonist-induced deficits in PPI. In our study, we evaluated the effect of four different %22atypical%22 antipsychotic drugs on deficits in PPI induced by MK-801. Zotepine and risperidone have high affinities to D2-like and 5-HT2A receptors, while clozapine and olanzapine have multipharmacological profiles with the highest affinities to serotonin 5-HT1A,2A/2C receptors and muscarinic receptors. Results have shown that MK-801 disrupted PPI and increased the ASR in rats. Our results showed no effect of zotepine (1 and 2 mg/kg) and risperidone (0,1 and 1 mg/kg) on disrupted PPI by MK-801. Administration of clozapine (5 and 10 mg/kg) and olanzapine" . "RIV/00023752:_____/05:00000476" . . . "Dizocilpine (MK-801; 0,3 mg/kg i.p.) - induced disruption in prepulse inhibition of the acoustic startle response (PPI) can be preferentially restored by %22atypical%22 antipsychotics. In contrast, some finding indicate that not all of the %22atypical%22 antipsychotics, such as clozapine and risperidone, are effective in restoring the NMDA antagonist-induced deficits in PPI. In our study, we evaluated the effect of four different %22atypical%22 antipsychotic drugs on deficits in PPI induced by MK-801. Zotepine and risperidone have high affinities to D2-like and 5-HT2A receptors, while clozapine and olanzapine have multipharmacological profiles with the highest affinities to serotonin 5-HT1A,2A/2C receptors and muscarinic receptors. Results have shown that MK-801 disrupted PPI and increased the ASR in rats. Our results showed no effect of zotepine (1 and 2 mg/kg) and risperidone (0,1 and 1 mg/kg) on disrupted PPI by MK-801. Administration of clozapine (5 and 10 mg/kg) and olanzapine"@en . "The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating"@cs . . . "519516" . "[2129E3C233F1]" . "The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating" . . "antipsychotics; prepulse inhiibiton of the startle response; rats; MK-801"@en . "RIV/00023752:_____/05:00000476!RIV06-MZ0-00023752" . "Buben\u00EDkov\u00E1, V\u011Bra" . "4"^^ . . . "Pharmacology Biochemistry and Behavior" . . "GB - Spojen\u00E9 kr\u00E1lovstv\u00ED Velk\u00E9 Brit\u00E1nie a Severn\u00EDho Irska" . "0091-3057" . . . "4" . "5"^^ . "The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating" . . "The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating"@en . . . . "6"^^ . "P(NL7684)" . "Aplikace dizocilpinu (MK-801;0,3 mg/kg i.p.) po\u0161kozuje prepulzn\u00ED inhibici akustick\u00E9 \u00FAlekov\u00E9 reakce (PPI). Deficit PPI navozen\u00FD MK-801 je p\u0159ednostn\u011B obnoven %22atypick\u00FDmi%22 antipsychotiky. Av\u0161ak n\u011Bkter\u00E9 n\u00E1lezy ukazuj\u00ED, \u017Ee ne v\u0161echna %22atypick\u00E1%22 antipsychotika, jako je clozapin a risperidon jsou \u00FA\u010Dinn\u00FD v obnoven\u00ED PPI. V na\u0161\u00ED studii jsme vyhodnotili \u00FA\u010Dinek \u010Dty\u0159 rozd\u00EDln\u00FDch %22atypick\u00FDch%22 antipsychotik na deficit v PPI navozen\u00FD aplikac\u00ED MK-801. Zotepin a risperidon vykazuj\u00ED vysokou afinitu k D2-like a 5-HT2A receptor\u016Fm, a\u010Dkoliv clozapin a olanzapin maj\u00ED multifarmakologick\u00FD profil s vysokou afinitou k serotoninov\u00FDm 5-HT1A a 5-HT2A/2C receptor\u016Fm a muskarinov\u00FDm receptor\u016Fm. V\u00FDsledky ukazuj\u00ED, \u017Ee MK-801 po\u0161kozuje PPI a zvy\u0161uje \u00FAlekovou reakci u potkan\u016F. Nebyl pozorov\u00E1n \u017E\u00E1dn\u00FD efekt zotepinu (1 a 2 mg/kg) a risperidonu (0,1 a 1 mg/kg) na deficit v PPI navozen\u00FD MK-801. Pod\u00E1n\u00ED clozapinu (5 a 10 mg/kg) a olanzapinu (2,5 a 5 mg/kg) obnovilo PPI po\u0161kozen\u00E9 MK-801. Pod\u00E1n\u00ED clozapinu v d\u00E1vce 5 mg/kg"@cs . .