"Sensorimotor gating is the ability of a weak sensory event to inhibit the motor response to an intense stimulus. Drugs that act as serotonin releasers, such as MDMA (3,4-methylenedioxymethamphetamine), impair sensorimotor gating., which is measured as a prepulse inhibition (PPI) of the acoustic startle response. The first objective of the present study was to compare the effect of different doses of MDMA on PPI and the acoustic startle response (ASR) in male and female Wistar rats. The second objective was to examine the effect of MDMA on PPI across the estrous cycle in female rats. MDMA was administered in doses of 2.5, 5 and 10 mg/kg s.c. 15 min before the start of the experiment. The controls received saline in equivalent volumes. MDMA dose-dependently decreased PPI in both the male and female rats and produced higher levels of ASR in the male rats compared to the females. In addition, we found that female rats in the diestrous and metestrous phases are more sensitive to MDMA and showed higher."@en . . . "Senzorimotorick\u00FD gating je schopnost slab\u00E9ho senzorick\u00E9ho podn\u011Btu inhibovat motorickou odpov\u011B\u010F vzniklou po aplikaci intenzivn\u00EDho podn\u011Btu.. L\u00E1tky, kter\u00E9 zvy\u0161uj\u00ED v\u00FDdej serotoninu, jako je MDMA (3,4-mehtylenedioxymethamphetamin), po\u0161kozuj\u00ED senozorimotorick\u00FD gating. Senzorimotorick\u00FD gating se m\u011B\u0159il jako \u00FArove\u0148 prepulzn\u00ED inhibice akustick\u00E9 \u00FAlekov\u00E9 reakce (PPI). Prvn\u00EDm c\u00EDlem studie bylo srovnat \u00FA\u010Dinek rozd\u00EDln\u00FDch d\u00E1vek MDMA na PPI a akustickou \u00FAlekovou reakce u samc\u016F a samic potkan\u016F kmene Wistar. Druh\u00FDm c\u00EDlem bylo ur\u010Dit efekt MDMA na PPI b\u011Bhem rozd\u00EDln\u00FDch f\u00E1z\u00ED estr\u00E1ln\u00EDho cyklu u samic. MDMA bylo aplikov\u00E1no v d\u00E1vk\u00E1ch 2,5, 5 a 10 mg/kg s.c., 15 min p\u0159ed po\u010D\u00E1tkem experimentu. Kontroly obdr\u017Eely fyziologick\u00FD roztok v ekvivalentn\u00EDm objemu. MDMA v z\u00E1vislosti na d\u00E1vce sni\u017Eovala PPI jak u samc\u016F tak samic. U samc\u016F byla nalezena zv\u00FD\u0161en\u00E1 \u00FAlekov\u00E1 reakce ve srovn\u00E1n\u00ED se samicemi. Samice v diestru a metestru byly v\u00EDce citliv\u00E9 na MDMA a vykazovaly v\u011Bt\u0161\u00ED po\u0161kozen\u00ED PPI ne\u017E samice v proestr\u00E1ln\u00ED a estr\u00E1ln\u00ED f\u00E1zi. Na\u0161e v\u00FDsledky uka"@cs . "Relation of sex and estrous phase to deficits in prepulse inhibition of the startle response induced by acstasy (MDMA)"@en . "Vztah pohlav\u00ED a extra na deficit prepulzn\u00ED inhibice \u00FAlekov\u00E9 reakce zp\u016Fsoben\u00FD ext\u00E1z\u00ED (MDMA)"@cs . . "Vztah pohlav\u00ED a extra na deficit prepulzn\u00ED inhibice \u00FAlekov\u00E9 reakce zp\u016Fsoben\u00FD ext\u00E1z\u00ED (MDMA)"@cs . . "Votava, M." . "Buben\u00EDkov\u00E1, V\u011Bra" . "Relation of sex and estrous phase to deficits in prepulse inhibition of the startle response induced by acstasy (MDMA)" . "Relation of sex and estrous phase to deficits in prepulse inhibition of the startle response induced by acstasy (MDMA)" . . "Relation of sex and estrous phase to deficits in prepulse inhibition of the startle response induced by acstasy (MDMA)"@en . "P\u00E1len\u00ED\u010Dek, Tom\u00E1\u0161" . . "540629" . . . . "RIV/00023752:_____/05:00000475!RIV06-MZ0-00023752" . . . "PPI; MDMA; sex differences; estrous cycle; rats"@en . "P(NJ7636)" . . "RIV/00023752:_____/05:00000475" . "16" . . "127-130" . . "[7EEDA9E4B286]" . . "4"^^ . "3"^^ . "Sensorimotor gating is the ability of a weak sensory event to inhibit the motor response to an intense stimulus. Drugs that act as serotonin releasers, such as MDMA (3,4-methylenedioxymethamphetamine), impair sensorimotor gating., which is measured as a prepulse inhibition (PPI) of the acoustic startle response. The first objective of the present study was to compare the effect of different doses of MDMA on PPI and the acoustic startle response (ASR) in male and female Wistar rats. The second objective was to examine the effect of MDMA on PPI across the estrous cycle in female rats. MDMA was administered in doses of 2.5, 5 and 10 mg/kg s.c. 15 min before the start of the experiment. The controls received saline in equivalent volumes. MDMA dose-dependently decreased PPI in both the male and female rats and produced higher levels of ASR in the male rats compared to the females. In addition, we found that female rats in the diestrous and metestrous phases are more sensitive to MDMA and showed higher." . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . . "2" . "4"^^ . . . "0955-8810" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "Behavioural Pharmacology" .