. "5"^^ . "553929" . "0862-8408" . . "H\u00F6schl, Cyril" . . "RIV/00023752:_____/04:00000418" . . . . "[639827FDF3B1]" . "3"^^ . "The calcium hypothesis of neurodegenerative disorders such as Alzheimer\u00B4s disease (AD) states that altered cytosolic Ca2+ levels (Ca2+)i and/or disturbances in Ca2+ homeostasis are the cellular mechanisms underlying neuronal pathology. To search for a diagnostic marker of Alzheimer\u00B4s disease (AD), we measured cytosolic calcium concentration ([Ca2+]i) in platelets of AD patients, age-matched control subjects (AMC), and vascular dementia (VD) patients. The (Ca2+)i was determined using long wavelength indicator Fluo-3AM in 21 mild AD patients, 17 AMC, and 23 patients with VD. The basal values of [Ca2+]i were significantly lower in AD compared to AMC. After the addition of 1 mM calcium, the [Ca2+]i markedly increased in platelets of AD compared to AMC and VD. Measurement of calcium homeostasis could provide a very sensitive, but less specific biological marker of AD. These results support the hypothesis that influencing calcium homeostasis may offer a therapeutic strategy in dementia." . "449-452" . "CZ - \u010Cesk\u00E1 republika" . . . . . "Jir\u00E1k, Roman" . . . "4"^^ . "Z(MZ00000023752)" . "Alzheimer`s disease;vascular dementia;platelets;calcium homeostasis;biological marker"@en . "53" . "Zm\u011Bny v homeost\u00E1zi kalcia jako biologick\u00FD marker pro za\u010D\u00EDnaj\u00EDc\u00ED Alzheimerovu demenci?"@cs . . . . . "Alterations in calcium homeostasis as biological marker for mild Alzheimer\u00B4s disease?"@en . "Alterations in calcium homeostasis as biological marker for mild Alzheimer\u00B4s disease?" . "Zm\u011Bny v homeost\u00E1zi kalcia jako biologick\u00FD marker pro za\u010D\u00EDnaj\u00EDc\u00ED Alzheimerovu demenci?"@cs . "RIV/00023752:_____/04:00000418!RIV/2005/MZ0/L28005/N" . "Alterations in calcium homeostasis as biological marker for mild Alzheimer\u00B4s disease?"@en . "Platilov\u00E1, Veronika" . "\u0158\u00EDpov\u00E1, Daniela" . "Alterations in calcium homeostasis as biological marker for mild Alzheimer\u00B4s disease?" . "Struneck\u00E1, Anna" . "The calcium hypothesis of neurodegenerative disorders such as Alzheimer\u00B4s disease (AD) states that altered cytosolic Ca2+ levels (Ca2+)i and/or disturbances in Ca2+ homeostasis are the cellular mechanisms underlying neuronal pathology. To search for a diagnostic marker of Alzheimer\u00B4s disease (AD), we measured cytosolic calcium concentration ([Ca2+]i) in platelets of AD patients, age-matched control subjects (AMC), and vascular dementia (VD) patients. The (Ca2+)i was determined using long wavelength indicator Fluo-3AM in 21 mild AD patients, 17 AMC, and 23 patients with VD. The basal values of [Ca2+]i were significantly lower in AD compared to AMC. After the addition of 1 mM calcium, the [Ca2+]i markedly increased in platelets of AD compared to AMC and VD. Measurement of calcium homeostasis could provide a very sensitive, but less specific biological marker of AD. These results support the hypothesis that influencing calcium homeostasis may offer a therapeutic strategy in dementia."@en . "4" . "Podle kalciov\u00E9 hypot\u00E9zy neurodegenerativn\u00EDho onemocn\u011Bn\u00ED Alzheimerova typu jsou patofyziologick\u00FDm podkladem tohoto onemocn\u011Bn\u00ED zm\u011Bny v hladin\u00E1ch \u010Di poruchy homeost\u00E1ze v\u00E1pn\u00EDku v bu\u0148ce. P\u0159i hled\u00E1n\u00ED diagnostick\u00E9ho markeru Alzheimerova onemocn\u011Bn\u00ED jsme m\u011B\u0159ili intracelul\u00E1rn\u00ED koncentraci voln\u00E9ho v\u00E1pn\u00EDku ([Ca2+]i ) v trombocytech pacient\u016F s vaskul\u00E1rn\u00ED demenc\u00ED, demenc\u00ED Alzheimerova typu a u v\u011Bkov\u011B korelovan\u00FDch nedementn\u00EDch jedinc\u016F. [Ca2+]ibyla m\u011B\u0159ena za pou\u017Eit\u00ED dlouhovlnn\u00E9ho fluorescen\u010Dn\u00EDho indik\u00E1toru Fluo-3AM u 21 pacient\u016F s za\u010D\u00EDnaj\u00EDc\u00ED demenc\u00ED Alzheimerova typu, u 17 v\u011Bkov\u011B korelovan\u00FDch nedementn\u00EDch kontrol a u 23 pacient\u016F s vaskul\u00E1rn\u00ED demenc\u00ED. Baz\u00E1ln\u00ED hladina [Ca2+]i byla signifikantn\u011B ni\u017E\u0161\u00ED u pacient\u016F s Alzheimerovou demenc\u00ED ne\u017E u kontrol. Po p\u0159id\u00E1n\u00ED 1 mM v\u00E1pn\u00EDku do inkuba\u010Dn\u00EDho media se v\u00FDrazn\u011B signifikantn\u011B zv\u00FD\u0161ila [Ca2+]i v porovn\u00E1n\u00ED s kontrolou i s pacienty s vaskul\u00E1rn\u00ED demenc\u00ED. M\u011B\u0159en\u00ED homeost\u00E1ze v\u00E1pn\u00EDku m\u016F\u017Ee b\u00FDt velmi citliv\u00FDm, ale pon\u011Bkud m\u00E9n\u011B specifick\u00FDm biologick\u00FDm markerem Alzheimerovy demence. Tyto"@cs . "Physiological Research" . . . .