"P(NF6031), P(NF7626)" . . . "7" . "RIV/00023752:_____/03:00000323" . . . . "RIV/00023752:_____/03:00000323!RIV/2004/MZ0/L28004/N" . . . "Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia" . . . . . "Balcar, Vladim\u00EDr Joseph" . "128-130" . "1211-7579" . . "Retroviruses can disrupt brain development, cause neuronal death and induce behavioural changes and therefore they have been proposed to play a role in the etiology of schizophrenia. Quinolinic acid (QUIN), released from retrovirus-infected brain macrophages and microglia, might be responsible, at least in part, for most of the proposed alterations. Intracerebroventricular infusion of QUIN to rat pups did cause a neuronal damage and evoked a subsequent diminution of the specific membrane binding of glutamate and changed their exploratory and acoustic startle activities in early adulthood. The changes were modified (potentiated) by increased levels of brain dopamine and inhibited by haloperidol and clozapine. Our present data suggest that increased levels of QUIN in neonatal rat brain can induce changes in the brain development and function have effects that exhibit some similarities to human schizophrenia."@en . . "4"^^ . "0"^^ . "Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia"@en . . . "0"^^ . "3"^^ . "633033" . . "Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia"@en . "Psychiatrie" . . . "3"^^ . "CZ - \u010Cesk\u00E1 republika" . . "schizophrenia; animal model; quinolinic acid; NMDA receptor; dopamine; haloperidol; clozapine; acoustic startle reaction; prepulse inhibition; open field test"@en . . "Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia" . "H\u00F6schl, Cyril" . . "Retroviruses can disrupt brain development, cause neuronal death and induce behavioural changes and therefore they have been proposed to play a role in the etiology of schizophrenia. Quinolinic acid (QUIN), released from retrovirus-infected brain macrophages and microglia, might be responsible, at least in part, for most of the proposed alterations. Intracerebroventricular infusion of QUIN to rat pups did cause a neuronal damage and evoked a subsequent diminution of the specific membrane binding of glutamate and changed their exploratory and acoustic startle activities in early adulthood. The changes were modified (potentiated) by increased levels of brain dopamine and inhibited by haloperidol and clozapine. Our present data suggest that increased levels of QUIN in neonatal rat brain can induce changes in the brain development and function have effects that exhibit some similarities to human schizophrenia." . . . "[72944537B4D7]" . "\u0160\u0165astn\u00FD, Franti\u0161ek" . "Suppl. 2" . . . "Tejkalov\u00E1, Hana" .