. . "RIV/00023752:_____/03:00000282!RIV/2004/MSM/L28004/N" . . "P\u00E1len\u00ED\u010Dek, Tom\u00E1\u0161" . "[F0FB7BCB00AE]" . "Suppl. 3" . "5"^^ . "P(LN00B122), P(NF6033), P(NL7684)" . "haloperidol; MK-801; schizophrenia; animal model; locomotion; antipsychotics; dopamine"@en . . "3"^^ . . . . "0"^^ . . "0"^^ . "3"^^ . "Psychiatrie" . . . "1211-7579" . "RIV/00023752:_____/03:00000282" . . "Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801" . "7" . "Hor\u00E1\u010Dek, Ji\u0159\u00ED" . "Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801" . "50-54" . "Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801"@en . . . "Haloperidol is a potent D2 antagonist, belonging to the so-called group of typical antipsychotics. It is effectively used in the treatment of schizophrenia. In our experimental setting we have evaluated the effects of haloperidol on psychosis-like reaction induced by non-competitive NMDA glutamate receptor antagonist, MK-801. We have monitored the locomotor reaction of rats in the open field, whereas we have targeted to evaluate the effects of haloperidol on hyperlocomotion induced by MK-801. We have found that MK-801 induced hyperolocomotor reaction was efficiently diminished by administration of haloperidol in a dose dependent manner. In our experimental setting we conclude that haloperidol was effective in counteracting MK-801 induced hyperlocomotion. Inasmuch as this model serves as a model of psychosis, we can extrapolate that haloperidol has an antipsychotic effect." . . "Effects of haloperidol on locomotion in animal model of schizophrenia induced by MK-801"@en . . . . . "Haloperidol is a potent D2 antagonist, belonging to the so-called group of typical antipsychotics. It is effectively used in the treatment of schizophrenia. In our experimental setting we have evaluated the effects of haloperidol on psychosis-like reaction induced by non-competitive NMDA glutamate receptor antagonist, MK-801. We have monitored the locomotor reaction of rats in the open field, whereas we have targeted to evaluate the effects of haloperidol on hyperlocomotion induced by MK-801. We have found that MK-801 induced hyperolocomotor reaction was efficiently diminished by administration of haloperidol in a dose dependent manner. In our experimental setting we conclude that haloperidol was effective in counteracting MK-801 induced hyperlocomotion. Inasmuch as this model serves as a model of psychosis, we can extrapolate that haloperidol has an antipsychotic effect."@en . . . . "CZ - \u010Cesk\u00E1 republika" . "Buben\u00EDkov\u00E1, V\u011Bra" . "605298" . . .