"Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate"@en . "RIV/00023752:_____/01:00000162" . "5" . . . . "Buben\u00EDkov\u00E1, V\u011Bra" . "Pliss, Lioudmila" . "N-Acetyl-aspartyl-glutamate (NAAG), the most abundant neuroactive peptide in the mammalian CNS, has only two known specific targets in brain tissue: ionotropic glutamate receptor of N-methyl-D-aspartate type and metabotropic G-protein linked glutamate receptors of class II. Several observations have pointed to a nexus between changes in the level of NAAG in brain and the development of neurodegenerative and mental diseases. The precise role of NAAG in neurodegeneration (or in healthy brain tissue) is, however, less clear. There could be a fine balance between the neuroprotective and neurotoxic actions of NAAG, depending on which one of the two populations of receptors targeted by NAAG is more active. The decisive factor could be the extracellular concentration (rather than overall tissue level) of NAAG and this can be manipulated in an animal model in vivo. Therefore, we have been using quantitative morphology, electron microscopy and molecular biological techniques to study and characterize the neuro" . . "P(LN00B122)" . . "RIV/00023752:_____/01:00000162!RIV/2002/MSM/L28002/N" . "Psychiatrie" . "675356" . "N-Acetyl-aspartyl-glutamate (NAAG), the most abundant neuroactive peptide in the mammalian CNS, has only two known specific targets in brain tissue: ionotropic glutamate receptor of N-methyl-D-aspartate type and metabotropic G-protein linked glutamate receptors of class II. Several observations have pointed to a nexus between changes in the level of NAAG in brain and the development of neurodegenerative and mental diseases. The precise role of NAAG in neurodegeneration (or in healthy brain tissue) is, however, less clear. There could be a fine balance between the neuroprotective and neurotoxic actions of NAAG, depending on which one of the two populations of receptors targeted by NAAG is more active. The decisive factor could be the extracellular concentration (rather than overall tissue level) of NAAG and this can be manipulated in an animal model in vivo. Therefore, we have been using quantitative morphology, electron microscopy and molecular biological techniques to study and characterize the neuro"@en . "N-Acetyl-aspartyl-glutamate, glutamate, N-acetyl-aspartate, neurodegeneration, necrosis, apoptosis"@en . . . . . . . . . "Suppl. 2" . "0"^^ . "4"^^ . "0"^^ . . "Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate" . "Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate"@en . . "[B3D83A44851A]" . . "Balcar, Vladim\u00EDr Joseph" . "3"^^ . . "\u0160\u0165astn\u00FD, Franti\u0161ek" . "2"^^ . "CZ - \u010Cesk\u00E1 republika" . . "Characterisation of hippocampal neurodegeneration after intracerebroventricular administration of n-acetyl-aspartyl-glutamate" . "102-104" . . "1211-7579" .