"Cholinester\u00E1zy a jejich v\u00FDznam v etiologii, diagnostice a terapii Alzheimerovy nemoci" . "\u0158\u00EDpov\u00E1, Daniela" . "675570" . . . . "50" . . . . "RIV/00023752:_____/01:00000161!RIV/2002/MZ0/L28002/N" . . "Cholinester\u00E1zy a jejich v\u00FDznam v etiologii, diagnostice a terapii Alzheimerovy nemoci"@cs . "CZ - \u010Cesk\u00E1 republika" . "acetylcholinesterases, butytylcholinesterases, Alzheimer`s disease"@en . "7"^^ . . "Cholinesterases and their significance for etiology, diatnostics, and therapy of the Alzheimer`s disease"@en . . . "4-10" . "Cholinester\u00E1zy jsou v\u00FDznamn\u00FDmi \u017Eivo\u010Di\u0161n\u00FDmi enzymy ze skupiny ester\u00E1z s rozd\u00EDlnou biologickou funkc\u00ED. Zat\u00EDmco acetylcholinestar\u00E1za (AChE) hraje kl\u00ED\u010Dovou \u00FAlohu v p\u0159enosu nervov\u00E9ho vzruchu v cholinergn\u00EDm nervov\u00E9m syst\u00E9mu, funkce butyrylcholinester\u00E1zy (BuChE) je nejasn\u00E1. Zd\u00E1 se, \u017Ee oba enzymy hraj\u00ED \u00FAlohu neurogenn\u00EDho faktoru v \u010Dasn\u00E9m stadiu v\u00FDvoje organismu, zat\u00EDmco v pozd\u011Bj\u0161\u00EDch f\u00E1z\u00EDch v\u00FDvoje se mohou pod\u00EDlet na n\u011Bkter\u00FDch patologick\u00FDch zm\u011Bn\u00E1ch. U \u010Dlov\u011Bka jsou n\u011Bkter\u00E9 degenerativn\u00ED zm\u011Bny spojov\u00E1ny s ukl\u00E1d\u00E1n\u00EDm patologick\u00FDch protein\u016F v mozku a se vznikem Alzheimerovy demence (AD). AChE i BuChE jsou v sou\u010Dasn\u00E9 dob\u011B c\u00EDlov\u00FDm m\u00EDstem pro nejpou\u017E\u00EDvan\u011Bj\u0161\u00ED skupinu l\u00E9\u010Div AD - inhibitory cholinester\u00E1z." . "Struneck\u00E1, Anna" . "[B65B07636D3E]" . "Cholinesterases and their significance for etiology, diatnostics, and therapy of the Alzheimer`s disease"@en . "Cholinester\u00E1zy a jejich v\u00FDznam v etiologii, diagnostice a terapii Alzheimerovy nemoci" . "Pato\u010Dka, Ji\u0159\u00ED" . "P(NG15), Z(MSM 113100003)" . "RIV/00023752:_____/01:00000161" . "1210-6313" . "Cholinester\u00E1zy a jejich v\u00FDznam v etiologii, diagnostice a terapii Alzheimerovy nemoci"@cs . . "Cholinesterases belong to esterases and represent important animal enzymes with multiple biological function. Acetylcholinesterase (AChE) plays the key role in cholinergic neurotransmission, whereas the function of butyrylcholinesterase (BuChE) is still unrevealed. Both enzymes seeem to act as neurogenic factors during the early embryogenesis and later on they may participate in some pathological alteration. In humans, these degenerative changes are related to the deposition of pathologic proteins in the brain and with the progress of the Alzheimer`s dementia (AD). Both AChE and BuChE become recently the target for the most frequently used therapy of AD - cholinesterase inhibitors."@en . . . "\u010Ceskoslovensk\u00E1 fyziologie" . . . "1"^^ . . "3"^^ . "0"^^ . "0"^^ . "1" . .