. . "5" . . "H\u00E1jek, Tom\u00E1\u0161" . . "Po\u0161kozen\u00ED hipokampu glukokortikoidy - kl\u00ED\u010Dov\u00FD patogenetick\u00FD faktor v psychiatrii?" . "7"^^ . "CZ - \u010Cesk\u00E1 republika" . . "[D2D38F4C3D06]" . "Po\u0161kozen\u00ED hipokampu glukokortikoidy - kl\u00ED\u010Dov\u00FD patogenetick\u00FD faktor v psychiatrii?" . "1211-7579" . . "Hippocampal atrophy induced by corticosteroids- key pathogenic factor in psychiatry?"@en . . "Po\u0161kozen\u00ED hipokampu glukokortikoidy - kl\u00ED\u010Dov\u00FD patogenetick\u00FD faktor v psychiatrii?"@cs . "Neurodegenerativn\u00ED p\u016Fsoben\u00ED glukokortikoid\u016F na hipokampus je z\u0159ejm\u011B v\u00FDznamn\u00FDm patogenetick\u00FDm \u010Dinitelem p\u0159i vzniku n\u011Bkter\u00FDch psychiatrick\u00FDch poruch. Hipokampus pat\u0159\u00ED k limbick\u00E9mu syst\u00E9mu a je c\u00EDlov\u00FDm org\u00E1nem p\u016Fsoben\u00ED glukokortikoid\u016F v CNS. P\u0159i jeho po\u0161kozen\u00ED doch\u00E1z\u00ED k deliberaci hypotalamo-hypofyzo-nadledvinov\u00E9 osy (HHN) a k poruch\u00E1m pam\u011Bti. Zn\u00E1mky zm\u011Bn\u011Bn\u00E9 aktivity HHN se v kombinaci s mnestick\u00FDm deficitem vyskytuj\u00ED u afektivn\u00EDch poruch, Alzheimerovy choroby, posttraumatick\u00E9 stresov\u00E9 poruchy. MRI volumetrie nav\u00EDc u zm\u00EDn\u011Bn\u00FDch chorob odhalila atrofii hipokampu. V prvn\u00ED \u010D\u00E1sti \u010Dl\u00E1nku jsou uvedeny experiment\u00E1ln\u00ED d\u016Fkazy pro hypot\u00E9zu o neurodegenerativn\u00EDm vlivu kortikoid\u016F u zv\u00ED\u0159at i lid\u00ED. Druh\u00E1 \u010D\u00E1st je zam\u011B\u0159ena na mechanismy \u0161kodliv\u00E9ho p\u016Fsoben\u00ED kortikoid\u016F,mo\u017Enosti jeho ovlivn\u011Bn\u00ED a implikace pro klinickou praxi. Na z\u00E1klad\u011B existuj\u00EDc\u00EDch dat jsou diskutov\u00E1ny sporn\u00E9 ot\u00E1zky - kauzalita a nezvratnost zm\u011Bn hipokampu, atrofie vs. nekr\u00F3za neuron\u016F, faktory zvy\u0161uj\u00EDc\u00ED vulnerabilitu hipokampu, a kontroverzn\u00ED n\u00E1lezy" . . "hippocampus, corticosteroids, dexamethasone suppresion test, affective disorder, posttraumatic stress disorder, Alzheimer\u00B4s disease"@en . "Po\u0161kozen\u00ED hipokampu glukokortikoidy - kl\u00ED\u010Dov\u00FD patogenetick\u00FD faktor v psychiatrii?"@cs . "1"^^ . "RIV/00023752:_____/01:00000083!RIV/2002/MZ0/L28002/N" . "0"^^ . "1"^^ . "0"^^ . "20-26" . "Hippocampal atrophy induced by corticosteroids- key pathogenic factor in psychiatry?"@en . . "P(NF6489)" . "1" . . . . . . "Psychiatrie" . . "Corticosteroids induced hippocampal atrophy may play an important role in the pathogenesis of a range of neuropsychiatric disorders. Hippocampal impairment leads to hypothalamo-pituitary-adrenal axis deliberation and memory deficit. Signs of HHN dysregulation in combination with memory impairment are present in affective disorders, Alzheimer\u00B4s disease and in posttraumatic stress disorder. MRI volumetry shows reduced hippocampal volume in these diseases. The findings are consistent with the results of animal experiments. Evidence supporting this hypothesis, putative mechanisms of corticosteroids' neurotoxicity, possible treatment approaches, and implications for clinical practice are reviewed. Unresolved questions concerning causality, reversibility, type of hippocampal changes, factors increasing hippocampal vulnerability, and ambiguous findings in posttraumatic stress disorder are discussed."@en . "RIV/00023752:_____/01:00000083" . . "691855" . . .