"Sd\u011Blen\u00ED uv\u00E1d\u00ED p\u0159ehled v\u00FDsledk\u016F nejd\u016Fle\u017Eit\u011Bj\u0161\u00EDch a nejv\u00FDznamn\u011Bj\u0161\u00ED klinick\u00FDch studi\u00ED, zab\u00FDvaj\u00EDc\u00EDch se problematikou implantace mononukle\u00E1rn\u00EDch kmenov\u00FDch bun\u011Bk kostn\u00ED d\u0159en\u011B u nemocn\u00FDch s velk\u00FDm akutn\u00EDm infarktem myokardu s poinfarktovou t\u011B\u017Ekou systolickou dysfunkc\u00ED lev\u00E9 komory. Celosv\u011Btov\u011B se v\u00FDzkum zam\u011B\u0159uje na tuto oblast ji\u017E n\u011Bkolik let. Nad\u011Bje se vkl\u00E1d\u00E1 p\u0159edev\u0161\u00EDm do mo\u017Enosti zabr\u00E1nit procesu progresivn\u00ED remodelace lev\u00E9 komory nahra\u017Een\u00EDm nekrotick\u00E9ho \u010Di fi broticky zm\u011Bn\u011Bn\u00E9ho myokardu kontraktiln\u00ED tk\u00E1n\u00ED, a t\u00EDm zabr\u00E1nit vzniku a rozvoji srde\u010Dn\u00EDho selh\u00E1n\u00ED. St\u0159edem pozornosti jsou p\u0159edev\u0161\u00EDm ti pacienti, u kter\u00FDch k obnov\u011B kontraktiln\u00ED funkce bezprost\u0159edn\u011B po p\u0159\u00EDhod\u011B nedo\u0161lo; jejich dlouhodob\u00E1 progn\u00F3za je dosud, i p\u0159es pokroky v sou\u010Dasn\u00E9 medic\u00EDn\u011B, \u010Dasto velmi nep\u0159\u00EDzniv\u00E1."@cs . "acute myocardial infarction; left ventricular ejection fraction; mononuclear bone marrow cells; stem cells"@en . "[1810176A4ED6]" . . "Intrakoron\u00E1rn\u00ED aplikace kmenov\u00FDch bun\u011Bk u nemocn\u00FDch s akutn\u00EDm infarktem myokardu, dosavadn\u00ED klinick\u00E9 zku\u0161enosti a perspektiva" . "5"^^ . "7-8" . . "Hor\u00E1k, J." . . "Cor et Vasa" . "Intrakoron\u00E1rn\u00ED aplikace kmenov\u00FDch bun\u011Bk u nemocn\u00FDch s akutn\u00EDm infarktem myokardu, dosavadn\u00ED klinick\u00E9 zku\u0161enosti a perspektiva"@cs . . "Kobylka, Petr" . . "CZ - \u010Cesk\u00E1 republika" . "Aschermann, M." . "1"^^ . . "V" . "Intracoronary delivery of stem cells in patients with acute myocardial infarction. The clinical experience obtained to date and prospects"@en . . "7"^^ . "RIV/00023736:_____/09:00008602" . "Intrakoron\u00E1rn\u00ED aplikace kmenov\u00FDch bun\u011Bk u nemocn\u00FDch s akutn\u00EDm infarktem myokardu, dosavadn\u00ED klinick\u00E9 zku\u0161enosti a perspektiva"@cs . . "Intracoronary delivery of stem cells in patients with acute myocardial infarction. The clinical experience obtained to date and prospects"@en . "Intrakoron\u00E1rn\u00ED aplikace kmenov\u00FDch bun\u011Bk u nemocn\u00FDch s akutn\u00EDm infarktem myokardu, dosavadn\u00ED klinick\u00E9 zku\u0161enosti a perspektiva" . "320206" . . "Skalick\u00E1, H." . . "RIV/00023736:_____/09:00008602!RIV10-MZ0-00023736" . . "51" . . . "Sd\u011Blen\u00ED uv\u00E1d\u00ED p\u0159ehled v\u00FDsledk\u016F nejd\u016Fle\u017Eit\u011Bj\u0161\u00EDch a nejv\u00FDznamn\u011Bj\u0161\u00ED klinick\u00FDch studi\u00ED, zab\u00FDvaj\u00EDc\u00EDch se problematikou implantace mononukle\u00E1rn\u00EDch kmenov\u00FDch bun\u011Bk kostn\u00ED d\u0159en\u011B u nemocn\u00FDch s velk\u00FDm akutn\u00EDm infarktem myokardu s poinfarktovou t\u011B\u017Ekou systolickou dysfunkc\u00ED lev\u00E9 komory. Celosv\u011Btov\u011B se v\u00FDzkum zam\u011B\u0159uje na tuto oblast ji\u017E n\u011Bkolik let. Nad\u011Bje se vkl\u00E1d\u00E1 p\u0159edev\u0161\u00EDm do mo\u017Enosti zabr\u00E1nit procesu progresivn\u00ED remodelace lev\u00E9 komory nahra\u017Een\u00EDm nekrotick\u00E9ho \u010Di fi broticky zm\u011Bn\u011Bn\u00E9ho myokardu kontraktiln\u00ED tk\u00E1n\u00ED, a t\u00EDm zabr\u00E1nit vzniku a rozvoji srde\u010Dn\u00EDho selh\u00E1n\u00ED. St\u0159edem pozornosti jsou p\u0159edev\u0161\u00EDm ti pacienti, u kter\u00FDch k obnov\u011B kontraktiln\u00ED funkce bezprost\u0159edn\u011B po p\u0159\u00EDhod\u011B nedo\u0161lo; jejich dlouhodob\u00E1 progn\u00F3za je dosud, i p\u0159es pokroky v sou\u010Dasn\u00E9 medic\u00EDn\u011B, \u010Dasto velmi nep\u0159\u00EDzniv\u00E1." . "The paper is an overview of results of landmark clinical trials addressing the issue of mononuclear bone marrow stem cell implantation in patients with a major acute myocardial infarction and severe post-MI left ventricular dysfunction. Worldwide research has focused on his topic for a couple of years. Most importantly, it is hoped to be able to block the process of progressive left ventricular remodeling replacing the necrotic or fi brotic myocardium by contractile tissue thereby precluding the development of heart failure. Attention has particularly centered on patients not resuming contractile function immediately after the event; despite all recent advances in medicine, their long-term prognosis is often fairly poor."@en . "0010-8650" . . "Linhart, A." . .