"Cardiovascular & Hematological Disorders : Drug Targets" . . . "Rho-signaling pathways in chronic myelogenous leukemia" . "Sign\u00E1ln\u00ED dr\u00E1hy Rho u chronick\u00E9 myeloidn\u00ED leuk\u00E9mie"@cs . "Onkoprotein BCR-ABL, jen\u017E je zodpov\u011Bdn\u00FD za patofysiologii chronick\u00E9 myeloidn\u00ED leuk\u00E9mie (CML), ovliv\u0148uje sign\u00E1ln\u00ED dr\u00E1hu RhoA/ROCK/LIM/kofilin, je\u017E reguluje sestavu aktinov\u00E9ho cytoskeletu a tud\u00ED\u017E bun\u011B\u010Dnou adhezi a migraci. P\u0159ehledn\u00FD refer\u00E1t pojedn\u00E1v\u00E1 o zn\u00E1m\u00FDch m\u00EDstech interference mezi proteinem BCR-ABL a sign\u00E1ln\u00EDmi dr\u00E1hami Rho a o \u00FA\u010Dinc\u00EDch l\u00E9\u010Diva Imatinib mesyl\u00E1tu na signalizaci Rho a adhezi bun\u011Bk CML ke slo\u017Ek\u00E1m extracelul\u00E1rn\u00ED matrice."@cs . . "Oncoprotein BCR-ABL that is responsible for the pathophysiology of chronic myelogenous leukemia (CML) affects the RhoA/ROCK/LIM/cofilin pathway that regulates the actin cytoskeleton assembly and thereby the cellular adhesion and migration. The review deals with the known points interference between BCR-ABL protein and Rho kinase signaling pathways and with the effects of the drug Imatinib mesylate on Rho signaling and CML cells adhesion to extracellular matrix compounds." . "7"^^ . . "RIV/00023736:_____/08:00007755" . . . . "Sign\u00E1ln\u00ED dr\u00E1hy Rho u chronick\u00E9 myeloidn\u00ED leuk\u00E9mie"@cs . "Rho-signaling pathways in chronic myelogenous leukemia"@en . . "1871-529X" . "4" . "2"^^ . "8" . "CML; BCR-ABL; adhesion; Rho GTPase"@en . "[DAC5092044D2]" . "Ku\u017Eelov\u00E1, Kate\u0159ina" . "NL - Nizozemsko" . "2"^^ . "Rho-signaling pathways in chronic myelogenous leukemia" . . "Oncoprotein BCR-ABL that is responsible for the pathophysiology of chronic myelogenous leukemia (CML) affects the RhoA/ROCK/LIM/cofilin pathway that regulates the actin cytoskeleton assembly and thereby the cellular adhesion and migration. The review deals with the known points interference between BCR-ABL protein and Rho kinase signaling pathways and with the effects of the drug Imatinib mesylate on Rho signaling and CML cells adhesion to extracellular matrix compounds."@en . "Hrkal, Zbyn\u011Bk" . . . . . . . . "Rho-signaling pathways in chronic myelogenous leukemia"@en . "392811" . "RIV/00023736:_____/08:00007755!RIV09-MZ0-00023736" . . "P(NR9243)" .