. . "390;398" . "6" . . "RIV/00023736:_____/07:00007132!RIV08-MZ0-00023736" . "RIV/00023736:_____/07:00007132" . "Z(MZ0UHKT2005)" . . "Nukleofosmin s aktivitou stimuluj\u00EDc\u00ED proliferaci nebo naopak potla\u010Duj\u00EDc\u00ED r\u016Fst n\u00E1doru"@cs . . "438058" . . "9"^^ . "[1CBB672DF8F5]" . "Fuchs, Ota" . "nucleosphomin; p(ARF) protein; centrosome; apoptosis; mutation; fusion proteins"@en . . . . "CZ - \u010Cesk\u00E1 republika" . "0862-495X" . "Klinick\u00E1 onkologie" . . "20" . . "1"^^ . . "Nukleophosmin with proliferative or growth \u2013 suppressive activity"@en . "Nukleofosmin (NPM) je siln\u011B zastoupen\u00FD multifunk\u010Dn\u00ED fosfoprotein s funkc\u00ED n\u00E1dorov\u00E9ho supresoru i onkogenu. Chromozom\u00E1ln\u00ED translokace zahrnuj\u00EDc\u00ED gen NPM1 byly nalezeny u myeloidn\u00EDch i lymfoidn\u00EDch malignit. Heterozygotn\u00ED mutace genu NPM1 jsou nej\u010Dast\u011Bj\u0161\u00EDmi genetick\u00FDmi defekty u akutn\u00ED myeloidn\u00ED leukemie (AML)"@cs . "1"^^ . "Nukleofosmin s aktivitou stimuluj\u00EDc\u00ED proliferaci nebo naopak potla\u010Duj\u00EDc\u00ED r\u016Fst n\u00E1doru"@cs . . . . "Nukleofosmin s aktivitou stimuluj\u00EDc\u00ED proliferaci nebo naopak potla\u010Duj\u00EDc\u00ED r\u016Fst n\u00E1doru" . . . . "Nucleophosmin (NPM) is an abundant multifunctional phosphoprotein with both tumor- suppressor and oncogenic functions. Chromosomal translocations involving the NPM1 gene were found in myeloid and lymphoid cancers. Heterozygous mutations of NPM1 gene are the most frequent genetic lesions in acute myeloid leukemia (AML)"@en . "Nukleofosmin (NPM) je siln\u011B zastoupen\u00FD multifunk\u010Dn\u00ED fosfoprotein s funkc\u00ED n\u00E1dorov\u00E9ho supresoru i onkogenu. Chromozom\u00E1ln\u00ED translokace zahrnuj\u00EDc\u00ED gen NPM1 byly nalezeny u myeloidn\u00EDch i lymfoidn\u00EDch malignit. Heterozygotn\u00ED mutace genu NPM1 jsou nej\u010Dast\u011Bj\u0161\u00EDmi genetick\u00FDmi defekty u akutn\u00ED myeloidn\u00ED leukemie (AML)" . "Nukleofosmin s aktivitou stimuluj\u00EDc\u00ED proliferaci nebo naopak potla\u010Duj\u00EDc\u00ED r\u016Fst n\u00E1doru" . "Nukleophosmin with proliferative or growth \u2013 suppressive activity"@en .