. "6" . "RIV/00023736:_____/05:00006090!RIV06-MZ0-00023736" . . "CZ - \u010Cesk\u00E1 republika" . "Kl\u00ED\u010Dov\u00E9 molekuly v p\u0159enosu sign\u00E1lu transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-\u00DF (TGF-\u00DF) podl\u00E9haj\u00ED degradaci v ubikvitin-proteasomov\u00E9m syst\u00E9mu. Inhibitor p\u0159enosu sign\u00E1lu TGF-\u00DF, proto-onkoprotein SnoN (\u201ESki related novel gene product\u201C) je tak\u00E9 degradov\u00E1n v ubikvitin-proteasomov\u00E9m syst\u00E9mu. Porucha p\u0159enosu sign\u00E1lu TGF-\u00DF u n\u00E1dorov\u00FDch bun\u011Bk m\u016F\u017Ee b\u00FDt zp\u016Fsobena ne\u0159\u00EDzenou degradac\u00ED slo\u017Eek sign\u00E1ln\u00ED dr\u00E1hy TGF-\u00DF v proteasomech a n\u00E1dorov\u00E9 bu\u0148ky se tak st\u00E1vaj\u00ED rezistentn\u00ED k anti-prolifera\u010Dn\u00EDmu \u00FA\u010Dinku TGF-\u00DF." . "The role of ubiquitin-proteasome system in transforming growth factor-\u00DF signalling and its importance."@en . "1"^^ . "1"^^ . . "Smad proteins; transforming growth factor-beta; ubiquitin-proteasome system; Smad ubiquitin ligases Smurf"@en . "[A2C8D8E4CFF7]" . . "RIV/00023736:_____/05:00006090" . . . . "The key transducer proteins in transforming growth factor-\u00DF (TGF-\u00DF) signalling undergo ubiquitin-proteasome mediated degradation. The inhibitor of TGF-\u00DF signalling proto-oncoprotein SnoN (Ski related novel gene product) is also a substrate for proteasome degradation. The dysregulated proteasomal degradation is a novel pathway how tumor cells silence TGF-\u00DF signalling and thus these cells are resistant to the anti-proliferative activity of TGF-\u00DF."@en . . . . "547744" . "\u00DAloha ubikvitin-proteasomov\u00E9ho syst\u00E9mu v p\u0159enosu sign\u00E1lu transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-\u00DF a jej\u00ED v\u00FDznam p\u0159i vzniku n\u00E1dor\u016F." . "8"^^ . . . "0862-495X" . "\u00DAloha ubikvitin-proteasomov\u00E9ho syst\u00E9mu v p\u0159enosu sign\u00E1lu transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-\u00DF a jej\u00ED v\u00FDznam p\u0159i vzniku n\u00E1dor\u016F."@cs . "Klinick\u00E1 onkologie" . "Kl\u00ED\u010Dov\u00E9 molekuly v p\u0159enosu sign\u00E1lu transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-\u00DF (TGF-\u00DF) podl\u00E9haj\u00ED degradaci v ubikvitin-proteasomov\u00E9m syst\u00E9mu. Inhibitor p\u0159enosu sign\u00E1lu TGF-\u00DF, proto-onkoprotein SnoN (\u201ESki related novel gene product\u201C) je tak\u00E9 degradov\u00E1n v ubikvitin-proteasomov\u00E9m syst\u00E9mu. Porucha p\u0159enosu sign\u00E1lu TGF-\u00DF u n\u00E1dorov\u00FDch bun\u011Bk m\u016F\u017Ee b\u00FDt zp\u016Fsobena ne\u0159\u00EDzenou degradac\u00ED slo\u017Eek sign\u00E1ln\u00ED dr\u00E1hy TGF-\u00DF v proteasomech a n\u00E1dorov\u00E9 bu\u0148ky se tak st\u00E1vaj\u00ED rezistentn\u00ED k anti-prolifera\u010Dn\u00EDmu \u00FA\u010Dinku TGF-\u00DF."@cs . . "\u00DAloha ubikvitin-proteasomov\u00E9ho syst\u00E9mu v p\u0159enosu sign\u00E1lu transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-\u00DF a jej\u00ED v\u00FDznam p\u0159i vzniku n\u00E1dor\u016F."@cs . . "\u00DAloha ubikvitin-proteasomov\u00E9ho syst\u00E9mu v p\u0159enosu sign\u00E1lu transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-\u00DF a jej\u00ED v\u00FDznam p\u0159i vzniku n\u00E1dor\u016F." . "P(NC7605)" . "The role of ubiquitin-proteasome system in transforming growth factor-\u00DF signalling and its importance."@en . . . "199;206." . "Fuchs, Ota" . "18" .