"[5B977F5DBD9F]" . "Provazn\u00EDkov\u00E1, Dana" . "CZ - \u010Cesk\u00E1 republika" . . . "Protein promyelocyt\u00E1rn\u00ED leuk\u00E9mie a porucha sign\u00E1ln\u00ED dr\u00E1hy transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-beta u akutn\u00ED promyelocyt\u00E1rn\u00ED leuk\u00E9mie." . "3"^^ . "144" . . "3"^^ . "Protein promyelocyt\u00E1rn\u00ED leuk\u00E9mie a porucha sign\u00E1ln\u00ED dr\u00E1hy transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-beta u akutn\u00ED promyelocyt\u00E1rn\u00ED leuk\u00E9mie."@cs . . "2" . "Protein promyelocyt\u00E1rn\u00ED leuk\u00E9mie (PML) se \u00FA\u010Dastn\u00ED regulace transkripce a hraje d\u016Fle\u017Eitou \u00FAlohu v apopt\u00F3ze, proliferaci a st\u00E1rnut\u00ED bun\u011Bk. V\u0161echny tyto aktivity PML jsou p\u0159ipisov\u00E1ny jeho funkc\u00EDm v j\u00E1d\u0159e bun\u011Bk. Cytoplazmatick\u00FD PML (cPML) m\u00E1 v\u00FDznamnou roli v p\u0159enosu sign\u00E1lu transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-\u00DF (TGF-\u00DF). Ztr\u00E1ta funk\u010Dn\u00EDho cPML vede nejen k akutn\u00ED promyelocyt\u00E1rn\u00ED leuk\u00E9mii, ale p\u0159isp\u00EDv\u00E1 obecn\u011B k rezistenci bun\u011Bk na TGF-\u00DF a vzniku n\u00E1dor\u016F." . "5"^^ . . "The promyelocytic leukaemia protein (PML) is involved in transcription regulation and plays an important role in apoptosis, proliferation and senescence of cells. All these activities of PML protein are ascribed to its nuclear function. Cytoplasmic PML (cPML) is very important for transforming growth factor-\u00DF (TGF-\u00DF) signalling. The loss of functional cPML induces not only acute promyelocytic leukaemia but it might influence behavior of cancer cells and their resistance to TGF-\u00DF."@en . "Protein promyelocyt\u00E1rn\u00ED leuk\u00E9mie a porucha sign\u00E1ln\u00ED dr\u00E1hy transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-beta u akutn\u00ED promyelocyt\u00E1rn\u00ED leuk\u00E9mie."@cs . "RIV/00023736:_____/05:00006089" . "Promyelocytic leukaemia protein and deffect of transforming growth factor-beta signalling in acute promyelocytic leukaemia."@en . . "Pe\u0161lov\u00E1, Gabriela" . "Protein promyelocyt\u00E1rn\u00ED leuk\u00E9mie a porucha sign\u00E1ln\u00ED dr\u00E1hy transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-beta u akutn\u00ED promyelocyt\u00E1rn\u00ED leuk\u00E9mie." . . "\u010Casopis l\u00E9ka\u0159\u016F \u010Desk\u00FDch" . "90;94." . . "0008-7335" . "Protein promyelocyt\u00E1rn\u00ED leuk\u00E9mie (PML) se \u00FA\u010Dastn\u00ED regulace transkripce a hraje d\u016Fle\u017Eitou \u00FAlohu v apopt\u00F3ze, proliferaci a st\u00E1rnut\u00ED bun\u011Bk. V\u0161echny tyto aktivity PML jsou p\u0159ipisov\u00E1ny jeho funkc\u00EDm v j\u00E1d\u0159e bun\u011Bk. Cytoplazmatick\u00FD PML (cPML) m\u00E1 v\u00FDznamnou roli v p\u0159enosu sign\u00E1lu transforma\u010Dn\u00EDho r\u016Fstov\u00E9ho faktoru-\u00DF (TGF-\u00DF). Ztr\u00E1ta funk\u010Dn\u00EDho cPML vede nejen k akutn\u00ED promyelocyt\u00E1rn\u00ED leuk\u00E9mii, ale p\u0159isp\u00EDv\u00E1 obecn\u011B k rezistenci bun\u011Bk na TGF-\u00DF a vzniku n\u00E1dor\u016F."@cs . . "Promyelocytic leukaemia protein and deffect of transforming growth factor-beta signalling in acute promyelocytic leukaemia."@en . "RIV/00023736:_____/05:00006089!RIV06-MZ0-00023736" . . . "acute promyelocytic leukaemia; promyelocytic leukaemia protein; SARA protein; Smad proteins; transforming growth factor-beta"@en . . "Fuchs, Ota" . . "539374" . . . . . "P(NC7605)" . . .