"Pluskalov\u00E1, Michaela" . "P(NL7681)" . "Univerzita Palack\u00E9ho v Olomouci \u2013 Vydavatelstv\u00ED" . . "RIV/00023736:_____/04:I0000058!RIV/2005/MZ0/L33005/N" . . . . . "80-244-0882-1" . "RIV/00023736:_____/04:I0000058" . "Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins." . . "By means of two-dimensional electrophoresis the effects of photodynamic therapy, ALA-PDT, were studied on leukemia cell lines HL60 and K562. By mass spectrometry (MALDI-TOF) the proteins affected by ALA-PDT were identified, among others the chaperones HSP60 and HSP90. ALA-PDT induced phosphorylation of HSP90 leading to the destabilization of the client (onco)protein BCR-ABL and its proteasomal degradation." . . . "Metodou dvojrozm\u011Brn\u00E9 elektrofor\u00E9zy byly studov\u00E1ny \u00FA\u010Dinky fotodynamick\u00E9 terapie, ALA-PDT, na leukemick\u00E9 bun\u011B\u010Dn\u00E9 linie HL60 a K562. Hmotnostn\u00ED spektrometri\u00ED (MALDI-TOF) byly identifikov\u00E1ny proteiny, je\u017E byly ALA-PDT ovlivn\u011Bny, krom\u011B jin\u00FDch chaperony HSP60 a HSP90. ALA-PDT indukovala v bu\u0148k\u00E1ch K562 fosforylaci HSP90 vedouc\u00ED k destabilizaci klientn\u00EDho (onko)proteinu BCR-ABL a jeho degradaci proteasomem."@cs . "Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins." . . . "HL60;K562;two-dimensional electrophoresis;photodynamic therapy;ALA-PDT;HSP90;BCR-ABL"@en . . "Halada, P." . . "4"^^ . "Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins."@en . "183-184" . "571439" . "2"^^ . "-\u010Dinky fotodynamick\u00E9 terapie (ALA-PDT) a rozd\u00EDln\u00E9 reakce bun\u011Bk v expresi a/nebo fosforylaci n\u011Bkter\u00FDch protein\u016F."@cs . "Leukemic cells treated with photodynamic therapy (ALA-PDT) exhibit different cell response in the expression and/or phosphorylation of some heat shock proteins."@en . "3"^^ . "[8081F8E4890F]" . . "Olomouc" . . "-\u010Dinky fotodynamick\u00E9 terapie (ALA-PDT) a rozd\u00EDln\u00E9 reakce bun\u011Bk v expresi a/nebo fosforylaci n\u011Bkter\u00FDch protein\u016F."@cs . . . . "Fr\u00E9bort, I., Walterov\u00E1 D. (ed.). Chemica 43S : supplement collected reports of the Natural science faculty, Palack\u00FD Univerzity Olomouc, Czech Republic" . . "By means of two-dimensional electrophoresis the effects of photodynamic therapy, ALA-PDT, were studied on leukemia cell lines HL60 and K562. By mass spectrometry (MALDI-TOF) the proteins affected by ALA-PDT were identified, among others the chaperones HSP60 and HSP90. ALA-PDT induced phosphorylation of HSP90 leading to the destabilization of the client (onco)protein BCR-ABL and its proteasomal degradation."@en . . . "Hrkal, Zbyn\u011Bk" . "Grebe\u0148ov\u00E1, Dana" . .