"Vyoral, Daniel" . "RIV/00023736:_____/03:00000051!RIV/2004/GA0/L33004/N" . "0036-5327" . "14"^^ . "157;170" . "CZ - \u010Cesk\u00E1 republika" . "Z104" . "625938" . . "Babu\u0161iak, Marek" . "Sborn\u00EDk l\u00E9ka\u0159sk\u00FD" . "Zinc is an essential trace element required by all living organisms. It plays critical roles in a wide variety of biochemical processes including growth, development and reproduction. In biological systems very little amount of zinc is free in solution. Zinc carries out his biological role as divalent cation bound to proteins. Zinc is a cofactor required for function of over 300 mammalian enzymes from all 6 major functional enzyme classes. In addition over thousand of genes in the human genome encode proteins with zinc finger domains. These proteins function as transcriptional regulators in many cellular events and play also role in protein-protein interactions. In humans, the significance of zinc is illustrated by devastating effect of zinc deficiency inducing dermatitis, diminished immune response, decreased healing and neurological changes."@en . . . . "Role of zinc in eukaryotic cells, zinc transporters and zinc-containing proteins." . "Fuchs, Ota" . . . . . "Role of zinc in eukaryotic cells, zinc transporters and zinc-containing proteins."@en . . "zinc; metallothionein; transport proteins ZIP and ZnT; zinc finger proteins; gene expression"@en . . . "[A507362A58BA]" . "RIV/00023736:_____/03:00000051" . . "4"^^ . . "Petr\u00E1k, Ji\u0159\u00ED" . "0"^^ . "4"^^ . . "0"^^ . . . "Role of zinc in eukaryotic cells, zinc transporters and zinc-containing proteins." . . . . . "2" . "Zinc is an essential trace element required by all living organisms. It plays critical roles in a wide variety of biochemical processes including growth, development and reproduction. In biological systems very little amount of zinc is free in solution. Zinc carries out his biological role as divalent cation bound to proteins. Zinc is a cofactor required for function of over 300 mammalian enzymes from all 6 major functional enzyme classes. In addition over thousand of genes in the human genome encode proteins with zinc finger domains. These proteins function as transcriptional regulators in many cellular events and play also role in protein-protein interactions. In humans, the significance of zinc is illustrated by devastating effect of zinc deficiency inducing dermatitis, diminished immune response, decreased healing and neurological changes." . "Role of zinc in eukaryotic cells, zinc transporters and zinc-containing proteins."@en . . "P(GA204/00/1059), P(NB6574)" .