"III. ko\u0161ick\u00E9 hematologick\u00E9 a transfuziologick\u00E9 dny s mezin\u00E1rodn\u00ED \u00FA\u010Dast\u00ED" . . . . . . "Z(MZ00237360001)" . "gene expression; array-based analyses; CML; hydroxyurea treatment"@en . . "1"^^ . "Ko\u0161ice" . . "Ko\u0161ice" . "RIV/00023736:_____/03:00000041" . "Using array technology four patients with chronic myeloid leukemia (CML) were tested at diagnosis and after starting administration of hydroxyurea. To detect the gene expression of peripheral blood mononuclears and granulocytes Human Cancer cDNA Arrays (CLONTECH) with 588 gene probes were used. Increased expression of JNK2, integrin alpha E, MMP-8, MMP-9 and decreased expression of CDK6, GADD153, ERBB-3, cadherin 5 were detected in both fractions of most patients. In some samples PCNA, HDGF, MAPK p38, CD59 increased expressions were found."@en . "RIV/00023736:_____/03:00000041!RIV/2004/MZ0/L33004/N" . "Bruchov\u00E1, Hana" . . "Vyu\u017Eit\u00ED bio\u010Dip\u016F pro sledov\u00E1n\u00ED genov\u00E9 exprese u pacient\u016F s leukemi\u00ED."@cs . . "Pomoc\u00ED bio\u010Dipov\u00E9 metody byly testov\u00E1ny 4 pacienti s chronickou myeloidn\u00ED leukemi\u00ED (CML) v dob\u011B diagn\u00F3zy a po zah\u00E1jen\u00ED l\u00E9\u010Dby hydroxyureou. Pro detekci expresn\u00EDch profil\u016F u mononukle\u00E1rn\u00EDch bun\u011Bk a granulocyt\u016F byly pou\u017Eity nylonov\u00E9 membr\u00E1ny Human Cancer cDNA Arrays (CLONTECH) s 588 genov\u00FDmi sondami. Zv\u00FD\u0161en\u00E1 exprese gen\u016F JNK2, integrin alpha E, MMP-8, MMP-9 a sn\u00ED\u017Een\u00E1 exprese gen\u016F CDK6, GADD153, ERBB-3, cadherin 5 byla detekov\u00E1na v obou bun\u011B\u010Dn\u00FDch frakc\u00ED. U n\u011Bkter\u00FDch vzork\u016F byla zji\u0161t\u011Bna zv\u00FD\u0161en\u00E1 exprese u gen\u016F PCNA, HDGF, MAPK p38, CD59." . "18;18" . "2003-01-01+01:00"^^ . "Brdi\u010Dka, Radim" . . . . . "Using array technology in analysis the gene expression in patients with leukemia."@en . . "634476" . . "2"^^ . "Using array technology in analysis the gene expression in patients with leukemia."@en . "0"^^ . "Vyu\u017Eit\u00ED bio\u010Dip\u016F pro sledov\u00E1n\u00ED genov\u00E9 exprese u pacient\u016F s leukemi\u00ED."@cs . . . "2"^^ . "[403F99EF08C4]" . "0"^^ . "Vyu\u017Eit\u00ED bio\u010Dip\u016F pro sledov\u00E1n\u00ED genov\u00E9 exprese u pacient\u016F s leukemi\u00ED." . . "Vyu\u017Eit\u00ED bio\u010Dip\u016F pro sledov\u00E1n\u00ED genov\u00E9 exprese u pacient\u016F s leukemi\u00ED." . "Neuveden" .