. . . "11"^^ . "Bone remodeling and bone loss are controlled by the RANKL-RABK-OPG axis. RANKL is also produced by Tcells after antigenic stimuli. These T cells may also participate in osteoclast development and activation. Thus, immune cells are involved in bone metabolism in both health and in the presence of inflamatory or autoimmune diseases such as rheumatoid arthritis. Inhibition of RANKL in patients with rheumatoid arthritis has no effect on the inflammatory action itself but prevents bone loss and development of erosions."@en . . "Kostn\u00ED remodelace, ztr\u00E1ta kosti jsou kontrolov\u00E1ny osou RANKL-RANK-OPG. RANKL je tak\u00E9 produkov\u00E1n tak\u00E9 T bu\u0148kami po antigenn\u00EDm stimulu. Tyto T bu\u0148ky se mohou pod\u00EDlet tak\u00E9 na v\u00FDvoji a aktivaci osteoklast\u016F.Imunitn\u00ED bu\u0148ky se tedy \u00FA\u010Dastn\u00ED kostn\u00EDho metabolismu jak ve zdrav\u00ED, tak v p\u0159\u00EDtomnosti z\u00E1n\u011Btliv\u00FDch nebo autoimunitn\u00EDch onemocn\u011Bn\u00ED jako je revmatoidn\u00ED atritida. Inhibice RANKL u pacient\u016F s revmatoidn\u00ED artritidou nem\u00E1 \u017E\u00E1dn\u00FD efekt na samotn\u00FD z\u00E1n\u011Btliv\u00FD d\u011Bj, ale br\u00E1n\u00ED kostn\u00ED ztr\u00E1t\u011B a vzniku eroz\u00ED."@cs . "[7BE3ECDF4CD3]" . . "1211-3778" . . . "157518" . . "RIV/00023728:_____/12:#0002045" . "1" . . . "Kostn\u00ED remodelace, ztr\u00E1ta kosti jsou kontrolov\u00E1ny osou RANKL-RANK-OPG. RANKL je tak\u00E9 produkov\u00E1n tak\u00E9 T bu\u0148kami po antigenn\u00EDm stimulu. Tyto T bu\u0148ky se mohou pod\u00EDlet tak\u00E9 na v\u00FDvoji a aktivaci osteoklast\u016F.Imunitn\u00ED bu\u0148ky se tedy \u00FA\u010Dastn\u00ED kostn\u00EDho metabolismu jak ve zdrav\u00ED, tak v p\u0159\u00EDtomnosti z\u00E1n\u011Btliv\u00FDch nebo autoimunitn\u00EDch onemocn\u011Bn\u00ED jako je revmatoidn\u00ED atritida. Inhibice RANKL u pacient\u016F s revmatoidn\u00ED artritidou nem\u00E1 \u017E\u00E1dn\u00FD efekt na samotn\u00FD z\u00E1n\u011Btliv\u00FD d\u011Bj, ale br\u00E1n\u00ED kostn\u00ED ztr\u00E1t\u011B a vzniku eroz\u00ED." . "R\u016F\u017Ei\u010Dkov\u00E1, Olga" . . . . . "RIV/00023728:_____/12:#0002045!RIV13-MZ0-00023728" . "Ovlivn\u011Bn\u00ED sign\u00E1ln\u00ED cesty RANK/RANKL/OPG" . "CZ - \u010Cesk\u00E1 republika" . . "Ovlivn\u011Bn\u00ED sign\u00E1ln\u00ED cesty RANK/RANKL/OPG" . "Modification of the RANK/RANKL/OPG signaling pathway"@en . "Ovlivn\u011Bn\u00ED sign\u00E1ln\u00ED cesty RANK/RANKL/OPG"@cs . "17" . "Ovlivn\u011Bn\u00ED sign\u00E1ln\u00ED cesty RANK/RANKL/OPG"@cs . . . "V" . "1"^^ . "Osteologick\u00FD bulletin" . . . "Modification of the RANK/RANKL/OPG signaling pathway"@en . "1"^^ . "Osteoporosis; rheumatoid arthritis; bone remodeling; RANK; RANKL; OPG; denusomab"@en .