. . . . "20" . . . . "Osteoimunologie" . . "RIV/00023728:_____/12:#0002044!RIV13-MZ0-00023728" . "Osteoimunologie"@cs . "Osteoimunologie" . . "17"^^ . "RANKL/RANK m\u00E1 z\u00E1sadn\u00ED roli v diferenciaci a p\u0159e\u017E\u00EDv\u00E1n\u00ED osteoklast\u016F. OPG (osteoprotegerin) a RANKL maj\u00ED z\u00E1sadn\u00ED \u00FAlohu v propojen\u00ED funkce osteoblast\u016F a osteoklast\u016F. St\u00E1vaj\u00ED se tak c\u00EDlem mo\u017En\u00E9ho farmakologick\u00E9ho ovlivn\u011Bn\u00ED kostn\u00ED resorpce. Po vazb\u011B RANKLu na RANK doch\u00E1z\u00ED k aktivaci sign\u00E1ln\u00ED kask\u00E1dy reguluj\u00EDc\u00ED diferenciaci a aktivaci osteoklast\u016F. RANKL-RANK stimulace je nepostradateln\u00E1 pro indukci osteoklastogeneze, ostatn\u00ED sign\u00E1ln\u00ED dr\u00E1hy mohou jen pozitivn\u011B \u010Di negativn\u011B tuto signalizaci ovlivnit." . . "[9A6C7DBF8687]" . . . "R\u016F\u017Ei\u010Dkov\u00E1, Olga" . . "RIV/00023728:_____/12:#0002044" . "CZ - \u010Cesk\u00E1 republika" . . "Osteoimmunology"@en . "RANKL/RANK play a crucial role in osteoclast differentiation and survival. OPG(osteoprotegerin) and RANKL have a key role in interconnecting osteoblast functions. Thus, they become a target of potential pharmacological influence of bone resorption. After RANKL binds to RANK, a signaling cascade regulating osteoclast differentiation and activation is activated. RANKL-RANK stimulation is indispensable for induction of osteoclastogenesis. The other signaling pathways may only influence this signaling positively or negatively."@en . . "V" . . "4" . . "1210-7905" . "Osteoimunologie"@cs . "1"^^ . "\u010Cesk\u00E1 revmatologie" . "1"^^ . "Osteoimmunology"@en . "157226" . "RANKL/RANK m\u00E1 z\u00E1sadn\u00ED roli v diferenciaci a p\u0159e\u017E\u00EDv\u00E1n\u00ED osteoklast\u016F. OPG (osteoprotegerin) a RANKL maj\u00ED z\u00E1sadn\u00ED \u00FAlohu v propojen\u00ED funkce osteoblast\u016F a osteoklast\u016F. St\u00E1vaj\u00ED se tak c\u00EDlem mo\u017En\u00E9ho farmakologick\u00E9ho ovlivn\u011Bn\u00ED kostn\u00ED resorpce. Po vazb\u011B RANKLu na RANK doch\u00E1z\u00ED k aktivaci sign\u00E1ln\u00ED kask\u00E1dy reguluj\u00EDc\u00ED diferenciaci a aktivaci osteoklast\u016F. RANKL-RANK stimulace je nepostradateln\u00E1 pro indukci osteoklastogeneze, ostatn\u00ED sign\u00E1ln\u00ED dr\u00E1hy mohou jen pozitivn\u011B \u010Di negativn\u011B tuto signalizaci ovlivnit."@cs . "osteoporosis; bone remodeling; RANKL; RANK; OPG"@en .