. "8"^^ . . "Bene\u0161, Jan" . "9"^^ . "Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact" . "RIV/00023001:_____/13:00058760!RIV14-MZ0-00023001" . "2213-1779" . . "6"^^ . "Objectives: The purpose of this study was to compare the prognostic impact of clinical and biomarker correlates of resting heart rate (HR) and chronotropic incompetence in heart failure (HF) patients. Background: The mechanisms and underlying pathophysiological influences of HR abnormalities in HF are incompletely understood. Methods: In a prospective pilot study, 81 patients with advanced systolic HF (97% were receiving beta-blockers) and 25 age-, sex-, and body-size matched healthy controls underwent maximal cardiopulmonary exercise testing with sampling of neurohormones and biomarkers. Results: Two-thirds of HF patients met criteria for chronotropic incompetence. Resting HR and HR reserve (HRR, a measure of chronotropic response) were not correlated with each other and were associated with distinct biomarker profiles. Resting HR correlated with increased myocardial stress (B-type natriuretic peptide [BNP]: r 1/4 0.26; pro A-type natriuretic peptide: r 1/4 0.24; N-terminal(NT)-proBNP: r 1/4 0.32) and inflammation (leukocyte count: r 1/4 0.28; highsensitivity C-reactive protein assay: r 1/4 0.25). In contrast, HRR correlated with the neurohumoral response to HF (copeptin: r 1/4 0.33; norepinephrine: r 1/4 0.29) but not with myocyte stress or injury reflected by natriuretic peptides or hs-troponin I. Patients in the lowest chronotropic incompetence quartile (HRR 0.38) displayed more advanced HF, reduced exercise capacity, ventilatory inefficiency, and poorer quality of life. Over a median follow-up of 17 months, the combined endpoint of death or urgent transplant/assist device implantation occurred more frequently in patients with higher resting HR (>67 beats/min) or lower HRR, with bothmarkers providing additive prognostic information. Conclusions: Increased resting HR and chronotropic incompetence may reflect different pathophysiological processes, provide incremental prognostic information, and represent distinct therapeutic targets."@en . "Bendlova, B." . . "Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact"@en . "http://ac.els-cdn.com/S2213177913001248/1-s2.0-S2213177913001248-main.pdf?_tid=94441636-8296-11e3-82e8-00000aab0f27&acdnat=1390307079_ed84d8efc224ca7767fd08705272bd65" . . . "heart rate, heart failure"@en . "10.1016/j.jchf.2013.03.008" . "Objectives: The purpose of this study was to compare the prognostic impact of clinical and biomarker correlates of resting heart rate (HR) and chronotropic incompetence in heart failure (HF) patients. Background: The mechanisms and underlying pathophysiological influences of HR abnormalities in HF are incompletely understood. Methods: In a prospective pilot study, 81 patients with advanced systolic HF (97% were receiving beta-blockers) and 25 age-, sex-, and body-size matched healthy controls underwent maximal cardiopulmonary exercise testing with sampling of neurohormones and biomarkers. Results: Two-thirds of HF patients met criteria for chronotropic incompetence. Resting HR and HR reserve (HRR, a measure of chronotropic response) were not correlated with each other and were associated with distinct biomarker profiles. Resting HR correlated with increased myocardial stress (B-type natriuretic peptide [BNP]: r 1/4 0.26; pro A-type natriuretic peptide: r 1/4 0.24; N-terminal(NT)-proBNP: r 1/4 0.32) and inflammation (leukocyte count: r 1/4 0.28; highsensitivity C-reactive protein assay: r 1/4 0.25). In contrast, HRR correlated with the neurohumoral response to HF (copeptin: r 1/4 0.33; norepinephrine: r 1/4 0.29) but not with myocyte stress or injury reflected by natriuretic peptides or hs-troponin I. Patients in the lowest chronotropic incompetence quartile (HRR 0.38) displayed more advanced HF, reduced exercise capacity, ventilatory inefficiency, and poorer quality of life. Over a median follow-up of 17 months, the combined endpoint of death or urgent transplant/assist device implantation occurred more frequently in patients with higher resting HR (>67 beats/min) or lower HRR, with bothmarkers providing additive prognostic information. Conclusions: Increased resting HR and chronotropic incompetence may reflect different pathophysiological processes, provide incremental prognostic information, and represent distinct therapeutic targets." . . "Borlaug, BA" . . . . "3" . . . "Jabor, Anton\u00EDn" . . "RIV/00023001:_____/13:00058760" . . . "1" . "Journal of the American college of cardiology : Heart failure" . . "US - Spojen\u00E9 st\u00E1ty americk\u00E9" . "102679" . "I, P(LH12052)" . . . "Kautzner, Josef" . "Kotr\u010D, Martin" . "Melenovsk\u00FD, Vojt\u011Bch" . . . "Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact" . "Jarolim, P." . . "Lefflerov\u00E1, Kate\u0159ina" . "Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact"@en . "[7C1A558320D0]" .