"7"^^ . . . . . "Impaired renal function; Diabetes mellitus; Sodium bicarbonate; Contrast-induced nephropathy"@en . "I" . "Bou\u010Dek, Petr" . . "Prevention of contrast-induced nephropathy in diabetic patients with impaired renal function: a randomized, double blind trial of sodium bicarbonate versus sodium chloride-based hydration" . . "RIV/00023001:_____/13:00058727" . "Prevention of contrast-induced nephropathy in diabetic patients with impaired renal function: a randomized, double blind trial of sodium bicarbonate versus sodium chloride-based hydration" . "\u0160arkady, Darina" . "Skibov\u00E1, Jelena" . . "Pu\u010Del\u00EDkov\u00E1, Tereza" . . . "99152" . "Prevention of contrast-induced nephropathy in diabetic patients with impaired renal function: a randomized, double blind trial of sodium bicarbonate versus sodium chloride-based hydration"@en . . . "Prevention of contrast-induced nephropathy in diabetic patients with impaired renal function: a randomized, double blind trial of sodium bicarbonate versus sodium chloride-based hydration"@en . "3" . "Pe\u010Denkov\u00E1, V\u011Bra" . "[239E43AE2CE6]" . . . . "Oliyarnyk, Olena" . . . "Aims: Diabetes mellitus and decreased renal function are important risk factors for contrast-induced nephropathy (CIN) in which oxidative stress damage may play a role. Alkalinization with sodium bicarbonate (NaHCO3) has been proposed as a means of reducing free-radical mediated renal injury; however, the effectiveness of NaHCO3 treatment to prevent CIN in high-risk patients remains uncertain. Methods: We performed a prospective, randomized, double blind, sodium chloride (NaCl) hydration-controlled study of NaHCO3 in 120 diabetic patients with impaired renal function (serum creatinine >= 100 mu mol/L) undergoing an elective procedure with use of low-osmolar contrast media. The primary endpoint was the incidence of CIN defined as creatinine increase of >= 25% and/or >= 44 mu mol/L within 2 days after contrast. Secondary end-points were maximal changes in serum creatinine and estimated glomerular filtration rate. Urine F2-isoprostane levels were also assessed as measure of oxidative stress. Results: There were no significant group differences in baseline characteristics except for the marginally lower age of the NaHCO3 treated patients (63 +/- 11 vs. 67 +/- 10 years; p = 0.05). CIN occurred in 7 (11.5%) and 5 (8.5%) patients of the NaHCO3 and NaCl groups, respectively (p = 0.76; incidence rate ratio 1.35; 95% CI 0.37-5.41). No significant differences were seen in secondary outcome measures and changes in the parameter of oxidative stress. Conclusions: In diabetic patients with renal function impairment sodium bicarbonate does not confer protection against contrast-induced nephropathy greater than sodium chloride-based hydration. Its specific role in mitigating oxidative stress damage in CIN is also not supported by our data." . . "Havrdov\u00E1, Terezia" . "101" . "0168-8227" . "6"^^ . "10.1016/j.diabres.2013.05.015" . "Aims: Diabetes mellitus and decreased renal function are important risk factors for contrast-induced nephropathy (CIN) in which oxidative stress damage may play a role. Alkalinization with sodium bicarbonate (NaHCO3) has been proposed as a means of reducing free-radical mediated renal injury; however, the effectiveness of NaHCO3 treatment to prevent CIN in high-risk patients remains uncertain. Methods: We performed a prospective, randomized, double blind, sodium chloride (NaCl) hydration-controlled study of NaHCO3 in 120 diabetic patients with impaired renal function (serum creatinine >= 100 mu mol/L) undergoing an elective procedure with use of low-osmolar contrast media. The primary endpoint was the incidence of CIN defined as creatinine increase of >= 25% and/or >= 44 mu mol/L within 2 days after contrast. Secondary end-points were maximal changes in serum creatinine and estimated glomerular filtration rate. Urine F2-isoprostane levels were also assessed as measure of oxidative stress. Results: There were no significant group differences in baseline characteristics except for the marginally lower age of the NaHCO3 treated patients (63 +/- 11 vs. 67 +/- 10 years; p = 0.05). CIN occurred in 7 (11.5%) and 5 (8.5%) patients of the NaHCO3 and NaCl groups, respectively (p = 0.76; incidence rate ratio 1.35; 95% CI 0.37-5.41). No significant differences were seen in secondary outcome measures and changes in the parameter of oxidative stress. Conclusions: In diabetic patients with renal function impairment sodium bicarbonate does not confer protection against contrast-induced nephropathy greater than sodium chloride-based hydration. Its specific role in mitigating oxidative stress damage in CIN is also not supported by our data."@en . . "7"^^ . . "RIV/00023001:_____/13:00058727!RIV14-MZ0-00023001" . "Diabetes research and clinical practice" . . . "000325424800012" . . "NL - Nizozemsko" . "http://www.sciencedirect.com/science/article/pii/S0168822713002209#" .