"RIV/00023001:_____/13:00058589!RIV14-MZ0-00023001" . "Vrozen\u00E9 hyperbilirubinemie a molekul\u00E1rn\u00ED mechanizmy \u017Eloutenky" . "2"^^ . . "Vnit\u0159n\u00ED l\u00E9ka\u0159stv\u00ED" . . . "heme - bilirubin - Gilbert's syndrome - Dubin-Johnson syndrome - Rotor syndrome - OATP1B1 - OATP1B3"@en . "Vrozen\u00E9 hyperbilirubinemie a molekul\u00E1rn\u00ED mechanizmy \u017Eloutenky"@cs . . "Neonatal hyperbilirubinemia and molecular mechanisms of jaundice"@en . "\u00DAvod shrnuje klasickou dr\u00E1hu degradace hemu a z n\u00ED odvozen\u00E9 rozd\u011Blen\u00ED \u017Eloutenek. N\u00E1sleduje popis vrozen\u00FDch \u017Eloutenek zn\u00E1m\u00FDch jako Crigler- Najjar\u016Fv, Gilbert\u016Fv, Dubin-Johnson\u016Fv a Rotor\u016Fv syndrom s d\u016Frazem na vysv\u011Btlen\u00ED molekul\u00E1rn\u00ED podstaty t\u011Bchto metabolick\u00FDch poruch. Zvl\u00E1\u0161tn\u00ED pozornost je v\u011Bnov\u00E1na ned\u00E1vno objeven\u00E9mu molekul\u00E1rn\u00EDmu mechanizmu Rotorova syndromu spo\u010D\u00EDvaj\u00EDc\u00EDmu v neschopnosti jater zp\u011Btn\u011B vychyt\u00E1vat frakci konjugovan\u00E9ho bilirubinu vylu\u010Dovan\u00E9ho prim\u00E1rn\u011B do krve a nikoliv do \u017Elu\u010Di. Sn\u00ED\u017Een\u00E1 schopnost jater vychyt\u00E1vat konjugovan\u00FD bilirubin p\u0159isp\u00EDv\u00E1 i k rozvoji hyperbilirubinemie u b\u011B\u017En\u00FDch onemocn\u011Bn\u00ED jater a \u017Elu\u010Dov\u00FDch cest a k toxicit\u011B xenobio tik a l\u00E9k\u016F vyu\u017E\u00EDvaj\u00EDc\u00EDch transportn\u00ED proteiny pro konjugovan\u00FD bilirubin"@cs . . . "6"^^ . "Jirsa, Milan" . "Vrozen\u00E9 hyperbilirubinemie a molekul\u00E1rn\u00ED mechanizmy \u017Eloutenky" . . . "7" . "\u00DAvod shrnuje klasickou dr\u00E1hu degradace hemu a z n\u00ED odvozen\u00E9 rozd\u011Blen\u00ED \u017Eloutenek. N\u00E1sleduje popis vrozen\u00FDch \u017Eloutenek zn\u00E1m\u00FDch jako Crigler- Najjar\u016Fv, Gilbert\u016Fv, Dubin-Johnson\u016Fv a Rotor\u016Fv syndrom s d\u016Frazem na vysv\u011Btlen\u00ED molekul\u00E1rn\u00ED podstaty t\u011Bchto metabolick\u00FDch poruch. Zvl\u00E1\u0161tn\u00ED pozornost je v\u011Bnov\u00E1na ned\u00E1vno objeven\u00E9mu molekul\u00E1rn\u00EDmu mechanizmu Rotorova syndromu spo\u010D\u00EDvaj\u00EDc\u00EDmu v neschopnosti jater zp\u011Btn\u011B vychyt\u00E1vat frakci konjugovan\u00E9ho bilirubinu vylu\u010Dovan\u00E9ho prim\u00E1rn\u011B do krve a nikoliv do \u017Elu\u010Di. Sn\u00ED\u017Een\u00E1 schopnost jater vychyt\u00E1vat konjugovan\u00FD bilirubin p\u0159isp\u00EDv\u00E1 i k rozvoji hyperbilirubinemie u b\u011B\u017En\u00FDch onemocn\u011Bn\u00ED jater a \u017Elu\u010Dov\u00FDch cest a k toxicit\u011B xenobio tik a l\u00E9k\u016F vyu\u017E\u00EDvaj\u00EDc\u00EDch transportn\u00ED proteiny pro konjugovan\u00FD bilirubin" . . "59" . . "http://www.vnitrnilekarstvi.cz/pdf?id=41149" . . "CZ - \u010Cesk\u00E1 republika" . "Neonatal hyperbilirubinemia and molecular mechanisms of jaundice"@en . . "N" . "RIV/00023001:_____/13:00058589" . "Sticov\u00E1, Eva" . "0042-773X" . "[ABE42F3723FF]" . . "The introductory summarises the classical path of heme degradation and classifi cation of jaundice. Subsequently, a description of neonatal types of jaundice is given, known as Crigler- Najjar, Gilbert's, Dubin-Johnson and Rotor syndromes, emphasising the explanation of the molecular mechanisms of these metabolic disorders. Special attention is given to a recently discovered molecular mechanism of the Rotor syndrome. The mechanism is based on the inability of the liver to retrospectively uptake the conjugated bilirubin fraction primarily excreted into the blood, not bile. A reduced ability of the liver to uptake the conjugated bilirubin contributes to the development of hyperbilirubinemia in common disorders of the liver and bile ducts and to the toxicity of xenobio tics and drugs using transport proteins for conjugated bilirubin"@en . "115141" . . "Vrozen\u00E9 hyperbilirubinemie a molekul\u00E1rn\u00ED mechanizmy \u017Eloutenky"@cs . "2"^^ .