"Annals of nutrition and metabolism" . "0250-6807" . "The oxidized low-density lipoprotein/beta2-glycoprotein I complex is associated with abdominal obesity in healthy middle-aged men"@en . . . "[5998C07A5094]" . "1" . "And\u011Bl, Michal" . "The oxidized low-density lipoprotein/beta2-glycoprotein I complex is associated with abdominal obesity in healthy middle-aged men" . "Poto\u010Dkov\u00E1, Jana" . . "Kraml, Pavel" . "CH - \u0160v\u00FDcarsk\u00E1 konfederace" . . "95100" . . "http://www.karger.com/Article/FullText/343049" . . "000314620900002" . . "V" . . . "The oxidized low-density lipoprotein/beta2-glycoprotein I complex is associated with abdominal obesity in healthy middle-aged men"@en . . "7"^^ . "RIV/00023001:_____/13:00057605!RIV14-MZ0-00023001" . . "Syrov\u00E1tka, Petr" . "4"^^ . "10.1159/000343049" . "The oxidized low-density lipoprotein/beta2-glycoprotein I complex is associated with abdominal obesity in healthy middle-aged men" . "Oxidized low-density lipoprotein (oxLDL) in complex with beta2-glycoprotein I (beta2GPI) has been associated with autoimmune diseases, diabetes mellitus, chronic renal disease and coronary atherosclerosis. The aim of our study was to determine whether plasma levels of oxLDL/beta2GPI complexes are associated with insulin resistance, inflammation and markers of endothelial damage in obese middle-aged men and, if so, whether oxLDL/beta2GPI correlates better with insulin resistance parameters than oxLDL, advanced oxidation protein products (AOPP) or thioredoxin. Methods: A total of 72 healthy men were recruited (41 obese and 31 nonobese individuals). Waist circumference >94 cm was used as the criterion for abdominal obesity. Results: The obese men demonstrated higher oxLDL/beta2GPI levels (p < 0.001), homeostasis model assessment of insulin resistance (p < 0.01) and intima-media thickness of the common carotid artery (p < 0.01). oxLDL/beta2GPI correlated with more insulin resistance parameters compared to AOPP, thioredoxin or oxLDL. Furthermore, oxLDL/beta2GPI was associated with plasminogen activator inhibitor-I (PAI-I; r = 0.365, p < 0.001) and negatively with interleukin-8 (r = -0.297, p < 0.05). Conclusions: In summary, oxLDL/beta2GPI reflects the criterion for abdominal obesity and markers of insulin resistance in our study. The independent positive correlation with PAI-I indicates that oxLDL/beta2GPI may serve as an early marker of low-grade inflammation and atherosclerosis initiation."@en . . . "oxLDL/beta2GPI, insulin resistance, inflammation, endothelial damage"@en . . "1"^^ . . "Oxidized low-density lipoprotein (oxLDL) in complex with beta2-glycoprotein I (beta2GPI) has been associated with autoimmune diseases, diabetes mellitus, chronic renal disease and coronary atherosclerosis. The aim of our study was to determine whether plasma levels of oxLDL/beta2GPI complexes are associated with insulin resistance, inflammation and markers of endothelial damage in obese middle-aged men and, if so, whether oxLDL/beta2GPI correlates better with insulin resistance parameters than oxLDL, advanced oxidation protein products (AOPP) or thioredoxin. Methods: A total of 72 healthy men were recruited (41 obese and 31 nonobese individuals). Waist circumference >94 cm was used as the criterion for abdominal obesity. Results: The obese men demonstrated higher oxLDL/beta2GPI levels (p < 0.001), homeostasis model assessment of insulin resistance (p < 0.01) and intima-media thickness of the common carotid artery (p < 0.01). oxLDL/beta2GPI correlated with more insulin resistance parameters compared to AOPP, thioredoxin or oxLDL. Furthermore, oxLDL/beta2GPI was associated with plasminogen activator inhibitor-I (PAI-I; r = 0.365, p < 0.001) and negatively with interleukin-8 (r = -0.297, p < 0.05). Conclusions: In summary, oxLDL/beta2GPI reflects the criterion for abdominal obesity and markers of insulin resistance in our study. The independent positive correlation with PAI-I indicates that oxLDL/beta2GPI may serve as an early marker of low-grade inflammation and atherosclerosis initiation." . . "RIV/00023001:_____/13:00057605" . "62" .