"Kidney and Blood Pressure Research" . . "The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula"@en . . . . "1420-4096" . . "6"^^ . "\u010Cervenka, Lud\u011Bk" . "Kopkan, Libor" . . . . "7"^^ . "http://content.karger.com/produktedb/produkte.asp?DOI=10.1159/000331562" . "000303273500005" . . "Heart failure, Volume overload, Mortality, Cardiac hypertrophy, Experimental models"@en . "Bene\u0161, Jan" . . . . "Melenovsk\u00FD, Vojt\u011Bch" . . "\u0160karoupkov\u00E1, Petra" . "128945" . "3" . "10.1159/000331562" . . "[E1E36FBF9FB4]" . . . . . . . . . "Torresov\u00E1, V\u011Bra" . "Background: There are only few studies documenting the long-term outcome of aorto-caval fistula (ACF) in rats, a model of volume overload heart failure (HF). The aim of the present study was to describe HF-related morbidity and mortality, and to examine the relation between cardiac hypertrophy and survival. Methods: Adult male Wistar rats underwent needle ACF or sham operation and 71 animals surviving the acute procedure with patent ACF were followed for 52 weeks. Results: By the end of the study, 72% of the ACF animals deceased and 82% developed HF signs. Of the HF rats, 65% died (median: 3 weeks after HF onset). Before death, body weight increased by 9% followed by a final drop. 28% ACF rats died suddenly, without preceding HF. Sudden death occurred earlier and in the rats with a trend to larger hearts (p = 0.07). In the whole ACF cohort, heart weight (heart weight/body weight ratio) was inversely associated with the length of survival (r = ?0.51, p ! 0.001). Conclusion: The median survival of ACF Wistar rats is 43 weeks, longer than reported in other rat strains. Increased heart weight is associated with higher mortality and a significant number of animals die suddenly." . "The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula" . "35" . . . "RIV/00023001:_____/12:00056133" . "CH - \u0160v\u00FDcarsk\u00E1 konfederace" . "Background: There are only few studies documenting the long-term outcome of aorto-caval fistula (ACF) in rats, a model of volume overload heart failure (HF). The aim of the present study was to describe HF-related morbidity and mortality, and to examine the relation between cardiac hypertrophy and survival. Methods: Adult male Wistar rats underwent needle ACF or sham operation and 71 animals surviving the acute procedure with patent ACF were followed for 52 weeks. Results: By the end of the study, 72% of the ACF animals deceased and 82% developed HF signs. Of the HF rats, 65% died (median: 3 weeks after HF onset). Before death, body weight increased by 9% followed by a final drop. 28% ACF rats died suddenly, without preceding HF. Sudden death occurred earlier and in the rats with a trend to larger hearts (p = 0.07). In the whole ACF cohort, heart weight (heart weight/body weight ratio) was inversely associated with the length of survival (r = ?0.51, p ! 0.001). Conclusion: The median survival of ACF Wistar rats is 43 weeks, longer than reported in other rat strains. Increased heart weight is associated with higher mortality and a significant number of animals die suddenly."@en . "The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula"@en . . "The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula" . "RIV/00023001:_____/12:00056133!RIV13-MZ0-00023001" . "6"^^ . "I, P(1M0510), P(GA305/09/1390), P(NS10497)" . .