"http://www.remedia.cz/Archiv-rocniku/Rocnik-2012/5-2012/Nazalni-aplikace-farmak-a-jeji-indikace-pohledem-anesteziologa/e-1dQ-1lK-1lO.magarticle.aspx" . . . . . . . "Naz\u00E1ln\u00ED aplikace farmak m\u00E1 dlouhou historii. Indi\u00E1ni Ji\u017En\u00ED Ameriky \u0161\u0148upali r\u016Fzn\u00E9 psychoaktivn\u00ED substance, v sou\u010Dasnosti se takto u\u017E\u00EDv\u00E1 p\u0159edev\u0161\u00EDm heroin nebo kokain. Naz\u00E1ln\u00ED cestou se ale aplikuj\u00ED i \u010Detn\u00E1 l\u00E9\u010Diva - v anesteziologii jsou to p\u0159edev\u0161\u00EDm sedativa, analgetika, jejich kombinace a specifi\u010Dt\u00ED antagonist\u00E9. D\u00E1le jsou v klinick\u00E9 praxi \u010Di ve f\u00E1zi v\u00FDzkumu nap\u0159\u00EDklad oxytocin, \u017Eensk\u00E9 pohlavn\u00ED hormony, gonadorelin, glukagon nebo l\u00E9\u010Diva proti migr\u00E9n\u011B. Naz\u00E1ln\u00ED zp\u016Fsob pod\u00E1n\u00ED je nebolestiv\u00FD, dob\u0159e akceptovateln\u00FD, n\u00E1stup a odezn\u011Bn\u00ED \u00FA\u010Dinku jsou rychl\u00E9. Farmaka se vst\u0159eb\u00E1vaj\u00ED nejen nosn\u00ED sliznic\u00ED, ale i p\u0159\u00EDmo \u010Dichov\u00FDmi neurony do mozku a mozkom\u00ED\u0161n\u00EDho moku. Nov\u00E9 naz\u00E1ln\u00ED aplik\u00E1tory - MAD a MADomitor - znamenaj\u00ED usnadn\u011Bn\u00ED naz\u00E1ln\u00EDho pod\u00E1n\u00ED l\u00E9\u010Div a roz\u0161\u00ED\u0159en\u00ED tohoto zp\u016Fsobu aplikace do r\u016Fzn\u00FDch odv\u011Btv\u00ED medic\u00EDny. Mezi indikace pat\u0159\u00ED prvn\u00ED pomoc, tlumen\u00ED poopera\u010Dn\u00ED bolesti, premedikace nebo rehabilitace."@cs . "Naz\u00E1ln\u00ED aplikace farmak m\u00E1 dlouhou historii. Indi\u00E1ni Ji\u017En\u00ED Ameriky \u0161\u0148upali r\u016Fzn\u00E9 psychoaktivn\u00ED substance, v sou\u010Dasnosti se takto u\u017E\u00EDv\u00E1 p\u0159edev\u0161\u00EDm heroin nebo kokain. Naz\u00E1ln\u00ED cestou se ale aplikuj\u00ED i \u010Detn\u00E1 l\u00E9\u010Diva - v anesteziologii jsou to p\u0159edev\u0161\u00EDm sedativa, analgetika, jejich kombinace a specifi\u010Dt\u00ED antagonist\u00E9. D\u00E1le jsou v klinick\u00E9 praxi \u010Di ve f\u00E1zi v\u00FDzkumu nap\u0159\u00EDklad oxytocin, \u017Eensk\u00E9 pohlavn\u00ED hormony, gonadorelin, glukagon nebo l\u00E9\u010Diva proti migr\u00E9n\u011B. Naz\u00E1ln\u00ED zp\u016Fsob pod\u00E1n\u00ED je nebolestiv\u00FD, dob\u0159e akceptovateln\u00FD, n\u00E1stup a odezn\u011Bn\u00ED \u00FA\u010Dinku jsou rychl\u00E9. Farmaka se vst\u0159eb\u00E1vaj\u00ED nejen nosn\u00ED sliznic\u00ED, ale i p\u0159\u00EDmo \u010Dichov\u00FDmi neurony do mozku a mozkom\u00ED\u0161n\u00EDho moku. Nov\u00E9 naz\u00E1ln\u00ED aplik\u00E1tory - MAD a MADomitor - znamenaj\u00ED usnadn\u011Bn\u00ED naz\u00E1ln\u00EDho pod\u00E1n\u00ED l\u00E9\u010Div a roz\u0161\u00ED\u0159en\u00ED tohoto zp\u016Fsobu aplikace do r\u016Fzn\u00FDch odv\u011Btv\u00ED medic\u00EDny. Mezi indikace pat\u0159\u00ED prvn\u00ED pomoc, tlumen\u00ED poopera\u010Dn\u00ED bolesti, premedikace nebo rehabilitace." . . "Naz\u00E1ln\u00ED aplikace farmak a jej\u00ED indikace pohledem anesteziologa" . . "nasal application, history, nasal mucosa physiology, pharmaceuticals for nasal application, nasal applicators, possibilities for application"@en . "22" . "4"^^ . . "Intranasal administration of pharmaceuticals and its indications viewed by an anesthesiologist"@en . . "Naz\u00E1ln\u00ED aplikace farmak a jej\u00ED indikace pohledem anesteziologa" . "RIV/00023001:_____/12:00056108!RIV13-MZ0-00023001" . "0862-8947" . "Naz\u00E1ln\u00ED aplikace farmak a jej\u00ED indikace pohledem anesteziologa"@cs . "Hess, Ladislav" . "CZ - \u010Cesk\u00E1 republika" . . "Naz\u00E1ln\u00ED aplikace farmak a jej\u00ED indikace pohledem anesteziologa"@cs . . "153424" . "1"^^ . "1"^^ . "Intranasal administration of pharmaceuticals and its indications viewed by an anesthesiologist"@en . . . . "Remedia" . . "5" . . . "[3E20AB0C0ADB]" . . "RIV/00023001:_____/12:00056108" . "Intranasal administration of drugs has a long history. Indians of South America snorted different psychoactive substances. Currently, heroin and cocaine are being used in such a way. Nasal route is also applied to numerous pharmaceuticals - in anesthesiology it is especially sedatives, analgesics, their combinations and specific antagonists. The nasal route is painless, well acceptable, with a fast onset and offset of action. Pharmaceuticals are absorbed not only by the nasal mucosa, but also directly by olfactory neurons into the brain and cerebrospinal fluid. New nasal applicators - MAD and MADomitor - mean facilitation of nasal administration of drugs and expansion of the application of this method into various branches of medicine. The indications include first aid, control of postoperative pain, premedication or rehabilitation."@en . . . "P(NT11284), P(VG20102015014), P(VG20102015041)" .