"Statins have become a cornerstone of cardiovascular prevention. However, their lipid lowering efficacy and, thus also, impact on event risk reduction, differ substantially between individuals. The major part of this inter-individual difference can be explained by genetic factors. Using the GWA approach, candidate genes that may modify the response to statin treatment have been detected. Variants rs646776 (CELSR2/PSRC1/SORT1), rs16996148 (CILP2/PBX4), rs11206510 (PCSK9) and rs693 (APOB) were analysed in 370 (146 males) dyslipidemic patients treated with statins (46.6% simvastatin, 41.5% atorvastatin, 11.9% lovastatin, 10 or 20 mg/day) and 470 normolipidemic controls (188 males). Lipid levels were available prior to and after 8-12 weeks of therapy. There was a significant decrease both in the total (7.36 +/- 1.28 -> 5.43 +/- 1.01 mmol/l) and LDL-cholesterol (4.72 +/- 1.35 -> 3.19 +/- 0.98 mmol/l) after treatment. The genotype frequencies of the three SNPs differed between patients and controls (rs646776, rs16996148, rs693). The carriers of the minor rs599838 genotype had a significantly lower response to statin treatment compared to common homozygotes (LDL-cholesterol, Delta-20.3% vs. Delta-32.0%). No other significant associations with lipid changes were detected. Together with variations of other, multiple gene loci the variant at CELSR2/PSRC1/SORT1 gene cluster may be useful for individualization of statin treatment leading to better outcomes of the treatment." . . "I, P(NS10579)" . . "10"^^ . "L\u00E1nsk\u00E1, V\u011Bra" . "10" . "http://versita.metapress.com/content/j4541166l31p1028/fulltext.pdf" . "177017" . "RIV/00023001:_____/12:00056023" . . "Vrablik, Michal" . . "Statins have become a cornerstone of cardiovascular prevention. However, their lipid lowering efficacy and, thus also, impact on event risk reduction, differ substantially between individuals. The major part of this inter-individual difference can be explained by genetic factors. Using the GWA approach, candidate genes that may modify the response to statin treatment have been detected. Variants rs646776 (CELSR2/PSRC1/SORT1), rs16996148 (CILP2/PBX4), rs11206510 (PCSK9) and rs693 (APOB) were analysed in 370 (146 males) dyslipidemic patients treated with statins (46.6% simvastatin, 41.5% atorvastatin, 11.9% lovastatin, 10 or 20 mg/day) and 470 normolipidemic controls (188 males). Lipid levels were available prior to and after 8-12 weeks of therapy. There was a significant decrease both in the total (7.36 +/- 1.28 -> 5.43 +/- 1.01 mmol/l) and LDL-cholesterol (4.72 +/- 1.35 -> 3.19 +/- 0.98 mmol/l) after treatment. The genotype frequencies of the three SNPs differed between patients and controls (rs646776, rs16996148, rs693). The carriers of the minor rs599838 genotype had a significantly lower response to statin treatment compared to common homozygotes (LDL-cholesterol, Delta-20.3% vs. Delta-32.0%). No other significant associations with lipid changes were detected. Together with variations of other, multiple gene loci the variant at CELSR2/PSRC1/SORT1 gene cluster may be useful for individualization of statin treatment leading to better outcomes of the treatment."@en . . "000300403600003" . . "1" . "[8A41EC775216]" . . "Variant within CELSR2/PSRC1/SORT1, but not within CILP2/PBX4, PCSK9 and APOB genes, has a potential to influence statin treatment efficacy"@en . "5"^^ . . "Prusikova, Martina" . . . . "Variant within CELSR2/PSRC1/SORT1, but not within CILP2/PBX4, PCSK9 and APOB genes, has a potential to influence statin treatment efficacy" . "9"^^ . "Ceska, Richard" . "1214-021X" . . . . "APOB; PCSK9; CILP2/PBX4; CELSR2/PSRC1/SORT1; treatment efficacy; pharmacogenetics; gene variants; statins; dyslipidemia"@en . "Zlatohlavek,, Lukas" . . . "10.2478/v10136-012-0001-3" . . "Journal of applied biomedicine" . . "CZ - \u010Cesk\u00E1 republika" . "RIV/00023001:_____/12:00056023!RIV13-MZ0-00023001" . "Ad\u00E1mkov\u00E1, V\u011Bra" . "Variant within CELSR2/PSRC1/SORT1, but not within CILP2/PBX4, PCSK9 and APOB genes, has a potential to influence statin treatment efficacy"@en . "Dlouh\u00E1, Dana" . . . "Rynekrov\u00E1, Jitka" . . . . "Variant within CELSR2/PSRC1/SORT1, but not within CILP2/PBX4, PCSK9 and APOB genes, has a potential to influence statin treatment efficacy" . . . . "Hub\u00E1\u010Dek, Jaroslav" . .