"Functional adaptation of transplanted kidney in children"@en . . "Funk\u010Dn\u00ED adaptace ledviny transplantovan\u00E9 d\u011Btem"@cs . "Foltynov\u00E1, Eva" . . . "137424" . "V\u00FDchodisko: Transplantace velk\u00E9ho mno\u017Estv\u00ED ledvinov\u00E9ho parenchymu m\u016F\u017Ee p\u0159isp\u00EDvat k dobr\u00E9 funkci \u0161t\u011Bpu. Metodika: Do retrospektivn\u00ED studie jsme za\u010Dlenili 57 d\u011Btsk\u00FDch p\u0159\u00EDjemc\u016F ledviny od zem\u0159el\u00E9ho d\u00E1rce, u nich\u017E byl nekomplikovan\u00FD potransplanta\u010Dn\u00ED pr\u016Fb\u011Bh a kte\u0159\u00ED m\u011Bli p\u0159i posledn\u00EDm kontroln\u00EDm vy\u0161et\u0159en\u00ED (5,42 +- 2,42 rok\u016F po transplantaci) funguj\u00EDc\u00ED ledvinov\u00FD \u0161t\u011Bp. Ze s\u00E9rov\u00E9 hladiny kreatininu jsme podle Schwartzova vzorce vypo\u010Detli odhadnutou (eGFR) a absolutn\u00ED (absGFR) glomerul\u00E1rn\u00ED filtraci. Zhodnotili jsme vztahy mezi mno\u017Estv\u00EDm transplantovan\u00E9ho parenchymu ledviny a \u00FArovn\u00ED GFR z n\u00E1sleduj\u00EDc\u00EDch hledisek: a) pom\u011Bru t\u011Blesn\u00E9 hmotnosti d\u00E1rce k hmotnosti p\u0159\u00EDjemce jako ukazatele relativn\u00EDho mno\u017Estv\u00ED transplantovan\u00E9ho parenchymu ledviny (index D/P); b) t\u011Blesn\u00E9 hmotnosti d\u00E1rce jako ukazatele absolutn\u00EDho mno\u017Estv\u00ED transplantovan\u00E9ho parenchymu; c) t\u011Blesn\u00E9 hmotnosti p\u0159\u00EDjemce jako ukazatele metabolick\u00FDch n\u00E1rok\u016F p\u0159\u00EDjemce. Na mno\u017Estv\u00ED transplantovan\u00E9ho parenchymu ledviny jsme usuzovali z t\u011Blesn\u00E9 hmotnosti d\u00E1rce. Funkci ledviny jsme zhodnotili ve t\u0159ech obdob\u00EDch: a) p\u0159i propu\u0161t\u011Bn\u00ED z nemocnice po transplantaci; b) za rok po transplantaci; c) na konci sledov\u00E1n\u00ED. V\u00FDsledky: Prok\u00E1zali jsme statisticky v\u00FDznamn\u00FD p\u0159\u00EDm\u00FD vztah mezi indexem D/P a eGFR ve t\u0159ech hodnocen\u00FDch odstupech po transplantaci. D\u00E1le jsme nalezli neline\u00E1rn\u00ED nep\u0159\u00EDmou z\u00E1vislost mezi indexem D/P a absGFR (r = 0,6035; 0,6291; 0,1720; P < 0,001; 0,001; N.S). T\u011Blesn\u00E1 hmotnost d\u00E1rce m\u011Bla jen mal\u00FD nebo \u017E\u00E1dn\u00FD vliv na \u00FArove\u0148 eGFR a v\u016Fbec nesouvisela s hodnotou absGFR. Prok\u00E1zali jsme v\u00FDznamnou nep\u0159\u00EDmou neline\u00E1rn\u00ED z\u00E1vislost mezi hmotnost\u00ED p\u0159\u00EDjemce a eGFR (r = 0,6417; 0,6036; 0,4084; P < 0,001; 0,001, 0,01) a jasnou p\u0159\u00EDmou line\u00E1rn\u00ED z\u00E1vislost mezi hmotnost\u00ED p\u0159\u00EDjemce a absGFR (r = 0,6637; 0,7395; 0,4173; P < 0,001; 0,001, 0,01). Z\u00E1v\u011Bry: Mno\u017Estv\u00ED transplantovan\u00E9ho ledvinov\u00E9ho parenchymu m\u011Blo jen hrani\u010Dn\u00ED \u010Di \u017E\u00E1dn\u00FD vliv na funkci ledviny v \u010Dasn\u00E9m i v pozdn\u00EDm potransplanta\u010Dn\u00EDm obdob\u00ED." . . . "10"^^ . "Seeman, Tom\u00E1\u0161" . "Vondr\u00E1k, Karel" . "Matou\u0161ovic, Karel" . "CZ - \u010Cesk\u00E1 republika" . "18" . "1" . "Funk\u010Dn\u00ED adaptace ledviny transplantovan\u00E9 d\u011Btem" . "Functional adaptation of transplanted kidney in children"@en . . "\u0160patenka, Jaroslav" . . "8"^^ . . "[5059E5EE24FC]" . . . . "\u0160tekl\u00E1\u010Dov\u00E1, Anna" . "Background: Transplantation of a large kidney parenchyma mass may positively influence the post-transplant graft function. Methods: Fifty seven kidney grafted children with uncomplicated post-transplant courses and with surviving grafts at the end of follow-up (5.42 +- 2.42 y after transplantation) were included in the study. We calculated the estimated (eGFR) and absolute (absGFR) glomerular filtration rates from serum creatinine levels by the Schwartz formula. We evaluated relationships between the transplanted kidney parenchyma mass and GFR with regard to: a) the individual ratio between the donor and the recipient body mass as a measure of the relative kidney parenchyma mass transplanted (D/P index); b) the donor body mass as an equivalent of the absolute quantity of transplanted kidney parenchyma; c) the recipient body mass as a measure of the recipient metabolic demands. We used the donor body weight as a marker of the transplanted kidney mass. We evaluated the kidney function at three periods: a) at discharge from the hospital after transplantation; b) one year after transplantation; c) at the end of follow-up. Results: We documented the significant direct relation between D/P index in the three evaluated post-transplant periods (r = 0.6064; 0.5599; 0.3146; P < 0.001; 0.001; 0.05 for the three periods). We found an indirect non-linear relation between index D/P and absGFR (r = 0.6035; 0.6291; 0.1720; P < 0.001; 0.001; N.S). The donor body mass displayed only minor or none effect on eGFR and was not related to the absGFR level. We found a significant indirect non-linear relation between the recipient body mass and eGFR (r = 0.6417; 0.6036; 0.4084; P < 0.001; 0.001, 0.01) and the linear relation between the recipient body mass and absGFR (r = 0.6637; 0.7395; 0.4173; P < 0.001; 0.001, 0.01). Conclusions: The transplanted kidney mass influenced the graft function only negligibly, both in the early and late post-transplant periods."@en . "Funk\u010Dn\u00ED adaptace ledviny transplantovan\u00E9 d\u011Btem"@cs . "P(NT11457), V" . "RIV/00023001:_____/12:00056017!RIV13-MZ0-00023001" . . . . "Burkert, Jan" . "RIV/00023001:_____/12:00056017" . . "http://www.tigis.cz/images/stories/Aktuality_nefro/2012/matousovic_avn_1-12.pdf" . . "kidney transplantation; absolute GFR; eGFR; body weight; kidney donor"@en . "L\u00E1nsk\u00E1, V\u011Bra" . "Janda, Jan" . . "Funk\u010Dn\u00ED adaptace ledviny transplantovan\u00E9 d\u011Btem" . "Aktuality v nefrologii" . "1210-955X" . . . "Du\u0161ek, Ji\u0159\u00ED" . "1"^^ . "V\u00FDchodisko: Transplantace velk\u00E9ho mno\u017Estv\u00ED ledvinov\u00E9ho parenchymu m\u016F\u017Ee p\u0159isp\u00EDvat k dobr\u00E9 funkci \u0161t\u011Bpu. Metodika: Do retrospektivn\u00ED studie jsme za\u010Dlenili 57 d\u011Btsk\u00FDch p\u0159\u00EDjemc\u016F ledviny od zem\u0159el\u00E9ho d\u00E1rce, u nich\u017E byl nekomplikovan\u00FD potransplanta\u010Dn\u00ED pr\u016Fb\u011Bh a kte\u0159\u00ED m\u011Bli p\u0159i posledn\u00EDm kontroln\u00EDm vy\u0161et\u0159en\u00ED (5,42 +- 2,42 rok\u016F po transplantaci) funguj\u00EDc\u00ED ledvinov\u00FD \u0161t\u011Bp. Ze s\u00E9rov\u00E9 hladiny kreatininu jsme podle Schwartzova vzorce vypo\u010Detli odhadnutou (eGFR) a absolutn\u00ED (absGFR) glomerul\u00E1rn\u00ED filtraci. Zhodnotili jsme vztahy mezi mno\u017Estv\u00EDm transplantovan\u00E9ho parenchymu ledviny a \u00FArovn\u00ED GFR z n\u00E1sleduj\u00EDc\u00EDch hledisek: a) pom\u011Bru t\u011Blesn\u00E9 hmotnosti d\u00E1rce k hmotnosti p\u0159\u00EDjemce jako ukazatele relativn\u00EDho mno\u017Estv\u00ED transplantovan\u00E9ho parenchymu ledviny (index D/P); b) t\u011Blesn\u00E9 hmotnosti d\u00E1rce jako ukazatele absolutn\u00EDho mno\u017Estv\u00ED transplantovan\u00E9ho parenchymu; c) t\u011Blesn\u00E9 hmotnosti p\u0159\u00EDjemce jako ukazatele metabolick\u00FDch n\u00E1rok\u016F p\u0159\u00EDjemce. Na mno\u017Estv\u00ED transplantovan\u00E9ho parenchymu ledviny jsme usuzovali z t\u011Blesn\u00E9 hmotnosti d\u00E1rce. Funkci ledviny jsme zhodnotili ve t\u0159ech obdob\u00EDch: a) p\u0159i propu\u0161t\u011Bn\u00ED z nemocnice po transplantaci; b) za rok po transplantaci; c) na konci sledov\u00E1n\u00ED. V\u00FDsledky: Prok\u00E1zali jsme statisticky v\u00FDznamn\u00FD p\u0159\u00EDm\u00FD vztah mezi indexem D/P a eGFR ve t\u0159ech hodnocen\u00FDch odstupech po transplantaci. D\u00E1le jsme nalezli neline\u00E1rn\u00ED nep\u0159\u00EDmou z\u00E1vislost mezi indexem D/P a absGFR (r = 0,6035; 0,6291; 0,1720; P < 0,001; 0,001; N.S). T\u011Blesn\u00E1 hmotnost d\u00E1rce m\u011Bla jen mal\u00FD nebo \u017E\u00E1dn\u00FD vliv na \u00FArove\u0148 eGFR a v\u016Fbec nesouvisela s hodnotou absGFR. Prok\u00E1zali jsme v\u00FDznamnou nep\u0159\u00EDmou neline\u00E1rn\u00ED z\u00E1vislost mezi hmotnost\u00ED p\u0159\u00EDjemce a eGFR (r = 0,6417; 0,6036; 0,4084; P < 0,001; 0,001, 0,01) a jasnou p\u0159\u00EDmou line\u00E1rn\u00ED z\u00E1vislost mezi hmotnost\u00ED p\u0159\u00EDjemce a absGFR (r = 0,6637; 0,7395; 0,4173; P < 0,001; 0,001, 0,01). Z\u00E1v\u011Bry: Mno\u017Estv\u00ED transplantovan\u00E9ho ledvinov\u00E9ho parenchymu m\u011Blo jen hrani\u010Dn\u00ED \u010Di \u017E\u00E1dn\u00FD vliv na funkci ledviny v \u010Dasn\u00E9m i v pozdn\u00EDm potransplanta\u010Dn\u00EDm obdob\u00ED."@cs .