"CZ - \u010Cesk\u00E1 republika" . . . . . "Pr\u016Fb\u011Bh cytokinov\u00E9 odezvy u zv\u00ED\u0159ec\u00EDho modelu nitrob\u0159i\u0161n\u00ED sepse modifikovan\u00E9 imunosupres\u00ED"@cs . "1214-2158" . . . "23" . . "G\u00FCrlich, Robert" . . "The course of cytokine response in an animal model of intraabdominal sepsis modified by immunosuppression"@en . . "http://www.prolekare.cz/anesteziologie-intenzivni-medicina-clanek/prubeh-cytokinove-odezvy-u-zvireciho-modelu-nitrobrisni-sepse-modifikovane-imunosupresi-37984" . "C\u00EDl studie: Diagnostika sepse u imunokompromitovan\u00FDch pacient\u016F je obt\u00ED\u017En\u00E1 pro jejich modifikovanou reakci na infekci. C\u00EDlem experimentu bylo porovn\u00E1n\u00ED \u010Dasn\u00E9 klinick\u00E9 a laboratorn\u00ED odpov\u011Bdi na sepsi mezi experiment\u00E1ln\u00ED skupinou septick\u00FDch miniprasat s imunosupres\u00ED a bez n\u00ED. Typ studie: Experiment\u00E1ln\u00ED, srovn\u00E1vac\u00ED. Materi\u00E1l a metoda: Experiment byl prov\u00E1d\u011Bn na miniprasatech. Sepse byla vyvol\u00E1na u\u017Eit\u00EDm modelu cek\u00E1ln\u00ED ligace a punkce (CLP). Miniprasata se shodn\u00FDmi vstupn\u00EDmi parametry byla randomizov\u00E1na do 3 skupin, skupiny sepse (n = 10), skupiny imunosuprese (n = 11) s pod\u00E1v\u00E1n\u00EDm trojkombinace imunosupresivn\u00EDch l\u00E9k\u016F (cyklosporin, metylprednisolon, mykofenol\u00E1t mofetil) p\u0159ed operac\u00ED a kontroln\u00ED skupiny (n = 6). Po celou dobu experimentu byly v t\u0159\u00EDhodinov\u00FDch intervalech monitorov\u00E1ny plazmatick\u00E9 hladiny vybran\u00FDch cytokin\u016F. V\u00FDsledky: U v\u0161ech CLP zv\u00ED\u0159at do\u0161lo k rozvoji septick\u00E9ho \u0161oku s teplotou a hemodynamickou odezvou. Kinetika plazmatick\u00FDch koncentrac\u00ED TNFalfa, IL-1beta,interferonu-gama a CRP byla podobn\u00E1 ve skupin\u011B zv\u00ED\u0159at se seps\u00ED i s imunosupres\u00ED. U imunosuprimovan\u00FDch zv\u00ED\u0159at byly hodnoty IL-4 signifikantn\u011B ni\u017E\u0161\u00ED po celou dobu sledov\u00E1n\u00ED, naopak u stejn\u00E9 skupiny byly hodnoty IL-8 zv\u00FD\u0161en\u00E9. Deset hodin po operaci byly hodnoty IL-6 v\u00FDznamn\u011B vy\u0161\u0161\u00ED ve skupin\u011B se seps\u00ED ne\u017E ve skupin\u011B s imunosupres\u00ED. Byl nalezen signifikantn\u011B vy\u0161\u0161\u00ED vzestup hladin IL-10 v 19., 22., a 25. hodin\u011B po operaci ve skupin\u011B imunosuprimovan\u00FDch zv\u00ED\u0159at ve srovn\u00E1n\u00ED se skupinou bez imunosuprese. Z\u00E1v\u011Br: V na\u0161em experimentu jsme zjistili signifikantn\u00ED rozd\u00EDly v cytokinov\u00E9 odpov\u011Bdi na experiment\u00E1ln\u011B navozenou sepsi mezi skupinami imunokompetentn\u00EDch a imunosuprimovan\u00FDch zv\u00ED\u0159at." . "Pr\u016Fb\u011Bh cytokinov\u00E9 odezvy u zv\u00ED\u0159ec\u00EDho modelu nitrob\u0159i\u0161n\u00ED sepse modifikovan\u00E9 imunosupres\u00ED" . "163261" . "RIV/00023001:_____/12:00055834" . "6"^^ . . "Merta, Du\u0161an" . . "7"^^ . . . "Pr\u016Fb\u011Bh cytokinov\u00E9 odezvy u zv\u00ED\u0159ec\u00EDho modelu nitrob\u0159i\u0161n\u00ED sepse modifikovan\u00E9 imunosupres\u00ED"@cs . "5"^^ . . . . "RIV/00023001:_____/12:00055834!RIV13-MZ0-00023001" . . . "Kudla, Michal" . . "2" . "Kieslichov\u00E1, Eva" . . . "[5815A76D67F2]" . "The course of cytokine response in an animal model of intraabdominal sepsis modified by immunosuppression"@en . "Ro\u010De\u0148, Milan" . . "Pr\u016Fb\u011Bh cytokinov\u00E9 odezvy u zv\u00ED\u0159ec\u00EDho modelu nitrob\u0159i\u0161n\u00ED sepse modifikovan\u00E9 imunosupres\u00ED" . "Objective: The diagnosis of sepsis in immunocompromised patients is difficult due to their modified response to infection. Our experiment was designed to compare the early clinical and laboratory response to sepsis between experimental groups of septic minipigs with and without immunosuppression. Design: Experimental, comparative study. Material and methods: Experiment was performed on minipigs. Sepsis was induced using a model of caecal ligation and puncture (CLP). Minipigs (with identical baseline parameters) were randomized into 3 group; the sepsis group (n = 10), the immunosuppression group (n = 11), which received immunosuppressive drugs (cyclosporine, methylprednisolone, mycophenolate mofetil) before surgery, and the sham group (n = 6). Plasmatic levels of selected cytokines throughout the experiment in three-hour interval were monitored. Results: All CLP animals developed septic shock with febrile and hemodynamic response. Also the kinetics of the plasma levels of TNFalfa, IL-1beta, interferon-gama and CRP in both experimental groups with and without immunosuppression was similar. In immunosuppressed animals the levels of IL-4 were significantly lower in all time periods observed, on the contrary a significant increase of IL-8 levels in the same experimental group was found as well. Ten hours after surgery, significantly higher level of IL-6 was found in the sepsis group as compared to the immunosuppression group. There was a significantly greater increase in levels of IL-10, 19, 22 and 25 hours after surgery in immunosuppressed animals compared to the group without immunosuppression. Conclusion: We found significant differencies in cytokine response to experimental sepsis between the groups of immunocompetent and immunosuppressed animals in our experiment."@en . "C\u00EDl studie: Diagnostika sepse u imunokompromitovan\u00FDch pacient\u016F je obt\u00ED\u017En\u00E1 pro jejich modifikovanou reakci na infekci. C\u00EDlem experimentu bylo porovn\u00E1n\u00ED \u010Dasn\u00E9 klinick\u00E9 a laboratorn\u00ED odpov\u011Bdi na sepsi mezi experiment\u00E1ln\u00ED skupinou septick\u00FDch miniprasat s imunosupres\u00ED a bez n\u00ED. Typ studie: Experiment\u00E1ln\u00ED, srovn\u00E1vac\u00ED. Materi\u00E1l a metoda: Experiment byl prov\u00E1d\u011Bn na miniprasatech. Sepse byla vyvol\u00E1na u\u017Eit\u00EDm modelu cek\u00E1ln\u00ED ligace a punkce (CLP). Miniprasata se shodn\u00FDmi vstupn\u00EDmi parametry byla randomizov\u00E1na do 3 skupin, skupiny sepse (n = 10), skupiny imunosuprese (n = 11) s pod\u00E1v\u00E1n\u00EDm trojkombinace imunosupresivn\u00EDch l\u00E9k\u016F (cyklosporin, metylprednisolon, mykofenol\u00E1t mofetil) p\u0159ed operac\u00ED a kontroln\u00ED skupiny (n = 6). Po celou dobu experimentu byly v t\u0159\u00EDhodinov\u00FDch intervalech monitorov\u00E1ny plazmatick\u00E9 hladiny vybran\u00FDch cytokin\u016F. V\u00FDsledky: U v\u0161ech CLP zv\u00ED\u0159at do\u0161lo k rozvoji septick\u00E9ho \u0161oku s teplotou a hemodynamickou odezvou. Kinetika plazmatick\u00FDch koncentrac\u00ED TNFalfa, IL-1beta,interferonu-gama a CRP byla podobn\u00E1 ve skupin\u011B zv\u00ED\u0159at se seps\u00ED i s imunosupres\u00ED. U imunosuprimovan\u00FDch zv\u00ED\u0159at byly hodnoty IL-4 signifikantn\u011B ni\u017E\u0161\u00ED po celou dobu sledov\u00E1n\u00ED, naopak u stejn\u00E9 skupiny byly hodnoty IL-8 zv\u00FD\u0161en\u00E9. Deset hodin po operaci byly hodnoty IL-6 v\u00FDznamn\u011B vy\u0161\u0161\u00ED ve skupin\u011B se seps\u00ED ne\u017E ve skupin\u011B s imunosupres\u00ED. Byl nalezen signifikantn\u011B vy\u0161\u0161\u00ED vzestup hladin IL-10 v 19., 22., a 25. hodin\u011B po operaci ve skupin\u011B imunosuprimovan\u00FDch zv\u00ED\u0159at ve srovn\u00E1n\u00ED se skupinou bez imunosuprese. Z\u00E1v\u011Br: V na\u0161em experimentu jsme zjistili signifikantn\u00ED rozd\u00EDly v cytokinov\u00E9 odpov\u011Bdi na experiment\u00E1ln\u011B navozenou sepsi mezi skupinami imunokompetentn\u00EDch a imunosuprimovan\u00FDch zv\u00ED\u0159at."@cs . . "\u010C\u00E1p, Ji\u0159\u00ED" . "P(NS10556), V" . "minipig; caecal ligation and puncture; cytokine; immunosuppression; sepsis"@en . "\u0160plichal, Igor" . "Anesteziologie a intenzivn\u00ED medic\u00EDna" .