"7"^^ . . . "Vasickova, L." . "Motykova, E." . "L\u00E1nsk\u00E1, V\u011Bra" . . . "OBJECTIVES: Obesity is associated with increased inflammation which represents a link to atherosclerosis and cardiovascular disease. Lipoprotein associated phospholipase A2 (Lp-PLA2) is an independent marker of inflammation and atherosclerosis risk. To assess the impact of weight loss on metabolic markers of atherosclerosis including Lp-PLA2 we examined a group of Czech non-diabetic obese/overweight children exposed to a lifestyle intervention. PATIENTS AND METHODS: Fourty unrelated overweight/obese non-diabetic Czech children (13.7 ? 2.1 years, average BMI at baseline 29.8 ? 2.6 kg/m2) underwent 4 weeks of lifestyle modification (reduction of energy intake to age matched optimum and supervised physical activity). Anthropometrical and biochemical variables were determined at baseline and after the intervention. Lp-PLA2 mass concentration was assessed using the ELISA kit. Wilcocson\u00B4s rank test and Spearman\u00B4s correlation were used for statistical analysis. RESULTS: A significant decrease of BMI and waist circumference was associated with significant changes of plasma lipoprotein and glycaemia levels. Mass concentration of Lp-PLA2 at the baseline was 402 ? 94 \u03BCg/ml, after the intervention 368 ? 105 \u03BCg/ml (p=0.008). Change in Lp-PLA2 was associated with triglyceride level decrease (p=0.009). CONCLUSION: Intensive lifestyle modification leading to body weight decrease results in significant changes of plasma lipoprotein levels and, also, a drop of Lp-PLA2 levels in paediatric obese patients. However, even after the intervention Lp-PLA2 concentrations in this patient group remain elevated suggesting possible increased atherosclerosis risk in later life."@en . . "OBJECTIVES: Obesity is associated with increased inflammation which represents a link to atherosclerosis and cardiovascular disease. Lipoprotein associated phospholipase A2 (Lp-PLA2) is an independent marker of inflammation and atherosclerosis risk. To assess the impact of weight loss on metabolic markers of atherosclerosis including Lp-PLA2 we examined a group of Czech non-diabetic obese/overweight children exposed to a lifestyle intervention. PATIENTS AND METHODS: Fourty unrelated overweight/obese non-diabetic Czech children (13.7 ? 2.1 years, average BMI at baseline 29.8 ? 2.6 kg/m2) underwent 4 weeks of lifestyle modification (reduction of energy intake to age matched optimum and supervised physical activity). Anthropometrical and biochemical variables were determined at baseline and after the intervention. Lp-PLA2 mass concentration was assessed using the ELISA kit. Wilcocson\u00B4s rank test and Spearman\u00B4s correlation were used for statistical analysis. RESULTS: A significant decrease of BMI and waist circumference was associated with significant changes of plasma lipoprotein and glycaemia levels. Mass concentration of Lp-PLA2 at the baseline was 402 ? 94 \u03BCg/ml, after the intervention 368 ? 105 \u03BCg/ml (p=0.008). Change in Lp-PLA2 was associated with triglyceride level decrease (p=0.009). CONCLUSION: Intensive lifestyle modification leading to body weight decrease results in significant changes of plasma lipoprotein levels and, also, a drop of Lp-PLA2 levels in paediatric obese patients. However, even after the intervention Lp-PLA2 concentrations in this patient group remain elevated suggesting possible increased atherosclerosis risk in later life." . . "[0AD3222083E5]" . . "Lifestyle modification induced weight loss and changes of cardiometabolic risk factors including lowering of inflammatory response in obese children"@en . "Ceska, R." . "Prusikova, M." . "obesity; atherosclerosis; cardiovascular risk; children; lipoprotein associated phospholipase A2 (Lp-PLA2); weight loss"@en . "SE - \u0160v\u00E9dsk\u00E9 kr\u00E1lovstv\u00ED" . "209534" . "0172-780X" . . . . "32" . "5"^^ . "Zlatohlavek, L." . "RIV/00023001:_____/11:00002504!RIV12-MZ0-00023001" . . . "suppl. 2" . "Lifestyle modification induced weight loss and changes of cardiometabolic risk factors including lowering of inflammatory response in obese children" . . . . "1"^^ . . "000300544200013" . . "Lifestyle modification induced weight loss and changes of cardiometabolic risk factors including lowering of inflammatory response in obese children"@en . "Vrablik, M." . . . . "I, P(NS10589), V" . "RIV/00023001:_____/11:00002504" . "Neuroendocrinology letters" . . "Lifestyle modification induced weight loss and changes of cardiometabolic risk factors including lowering of inflammatory response in obese children" .