"[D9B482121F03]" . . . "Nitric oxide belongs to the most important factors influencing structural and functional properties of vessel wall. Both genetic and environmental factors may influence its metabolism. The aim of this study was to explore whether two common polymorphisms of endothelial nitric synthase (eNOS) may, jointly with smoking, influence the stiffness of large arteries, quantified as pulse wave velocity (PWV). One hundred ninety four subjects free of manifest atherosclerotic disease or chronic pharmacotherapy were selected from population-based postMONICA study. PWV s were measured using Sphygmocor(R) device between carotic and femoral arteries (aortic PWV) and between femoral and tibialis-posterior arteries (peripheral PWV). Two common polymorphisms, T786C and G894T, were assessed. Among current smokers, homo- or heterozygous carriers of T786C mutation showed significantly higher peripheral PWV than normal genotype carriers (14.0 vs 10.7 m/sec, p<0.002); the same applied to the carriers of G894T mutation (1" . . "59" . . . . "CZ - \u010Cesk\u00E1 republika" . "4" . . . . "0862-8408" . . "8"^^ . "Physiological Research" . "\u0160imon, J." . "The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness" . "C\u00EDfkov\u00E1, Renata" . "000282054700006" . "Nitric oxide belongs to the most important factors influencing structural and functional properties of vessel wall. Both genetic and environmental factors may influence its metabolism. The aim of this study was to explore whether two common polymorphisms of endothelial nitric synthase (eNOS) may, jointly with smoking, influence the stiffness of large arteries, quantified as pulse wave velocity (PWV). One hundred ninety four subjects free of manifest atherosclerotic disease or chronic pharmacotherapy were selected from population-based postMONICA study. PWV s were measured using Sphygmocor(R) device between carotic and femoral arteries (aortic PWV) and between femoral and tibialis-posterior arteries (peripheral PWV). Two common polymorphisms, T786C and G894T, were assessed. Among current smokers, homo- or heterozygous carriers of T786C mutation showed significantly higher peripheral PWV than normal genotype carriers (14.0 vs 10.7 m/sec, p<0.002); the same applied to the carriers of G894T mutation (1"@en . "The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness"@en . . . "264381" . "6"^^ . . "pulse wave velocity; nitric oxide synthase; T786C; G894T; polymorphism; smoking"@en . . "The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness" . "P(NR9333)" . . . "Pe\u0161ta, M." . "RIV/00023001:_____/10:00002296" . "The interaction of endothelial nitric oxide synthase polymorphism and current smoking in terms of increased arterial stiffness"@en . "1"^^ . . "RIV/00023001:_____/10:00002296!RIV11-MZ0-00023001" . . "Mayer, O." . "Filipovsk\u00FD, J." . "Dolej\u0161ov\u00E1, M." .