"Mal\u00EDnsk\u00E1, Hana" . . . . . "Oliyarnyk, Olena" . "335" . "Landa, V." . "000273812100014" . . . "\u0160im\u00E1kov\u00E1, M." . . "1-2" . . . . "RIV/00023001:_____/10:00002190!RIV11-MZ0-00023001" . . "Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis"@en . "Z\u00EDdek, V." . "0300-8177" . "P(IAA500110604), P(NR9359), P(NR9387), P(NS9696), Z(AV0Z50110509)" . . "steatohepatitis; trangenic rats; SREBP-1a; dyslipidemia; PUFA"@en . "Hubov\u00E1, Miriam" . . . . "NL - Nizozemsko" . . "263367" . "4"^^ . "The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. Recently, we developed an experimental model of hepatic steatosis and NASH, the transgenic spontaneously hypertensive rat (SHR) that overexpresses a dominant positive form of the human SREBP-1a isoform in the liver. These rats are genetically predisposed to hepatic steatosis at a young age that ultimately progresses to NASH in older animals. Young transgenic SHR versus SHR controls exhibited simple hepatic steatosis which was associated with significantly increased hepatic levels of oxidative stress markers, conjugated dienes, and TBARS, with decreased levels of antioxidative enzymes and glutathione and lower concentrations of plasma ?- and ?-tocopherol. Transgenic rats exhibited increased plasma levels of saturated FA, decreased levels of n-3 and n-6 polyunsaturated FA (PUFA), and increas"@en . . "7"^^ . . "[CABA9FF10DB8]" . "Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis"@en . "Mlejnek, P." . . . "Molecular and cellular biochemistry" . . "The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. Recently, we developed an experimental model of hepatic steatosis and NASH, the transgenic spontaneously hypertensive rat (SHR) that overexpresses a dominant positive form of the human SREBP-1a isoform in the liver. These rats are genetically predisposed to hepatic steatosis at a young age that ultimately progresses to NASH in older animals. Young transgenic SHR versus SHR controls exhibited simple hepatic steatosis which was associated with significantly increased hepatic levels of oxidative stress markers, conjugated dienes, and TBARS, with decreased levels of antioxidative enzymes and glutathione and lower concentrations of plasma ?- and ?-tocopherol. Transgenic rats exhibited increased plasma levels of saturated FA, decreased levels of n-3 and n-6 polyunsaturated FA (PUFA), and increas" . . "Pravenec, M." . "Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis" . . "RIV/00023001:_____/10:00002190" . . "Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitits in SREBP-1a spontaneously hypertensive rats with predisposition to hepatic steatosis" . . "Kazdov\u00E1, Ludmila" . "9"^^ .