"Pi\u0165ha, Jan" . . "Hub\u00E1\u010Dek, Jaroslav" . "Skalick\u00E1, H." . . "P(1M0510), P(NR9093)" . . "Poledne, Rudolf" . "CZ - \u010Cesk\u00E1 republika" . "Coronary artery disease is a serious health problem worldwide caused by the interaction between genetic and environmental risk factors. One of the candidate genes is a gene for apolipoprotein E. We present case report of two young smoking and obese carriers (man 45 years and woman 32 years old) of the apolipoprotein E (p.Arg136Cys) mutation, but with no severe dyslipidemias detected among 1,577 survivors (1,483 men, 94 women, aged 21-75 years) of acute coronary syndrome screened for genetic and traditional cardiovascular risk factors. Despite this mutation raises suspicion to be risk factor for cardiovascular disease (based on previous publications), its frequency was very low and similar to the control population (12 detected carriers of the mutation within the 9,386 screened individuals). Therefore, if this rare mutation is causal for the development of myocardial infarction needs to be further evaluated."@en . . . . "000267604600006" . . "3" . . "Stan\u011Bk, Vladim\u00EDr" . "Folia biologica (Praha)" . "0015-5500" . "apolipoprotein E; acute coronary syndrome; polymorphism"@en . "RIV/00023001:_____/09:00001968!RIV10-MZ0-00023001" . "303710" . . "Coronary artery disease is a serious health problem worldwide caused by the interaction between genetic and environmental risk factors. One of the candidate genes is a gene for apolipoprotein E. We present case report of two young smoking and obese carriers (man 45 years and woman 32 years old) of the apolipoprotein E (p.Arg136Cys) mutation, but with no severe dyslipidemias detected among 1,577 survivors (1,483 men, 94 women, aged 21-75 years) of acute coronary syndrome screened for genetic and traditional cardiovascular risk factors. Despite this mutation raises suspicion to be risk factor for cardiovascular disease (based on previous publications), its frequency was very low and similar to the control population (12 detected carriers of the mutation within the 9,386 screened individuals). Therefore, if this rare mutation is causal for the development of myocardial infarction needs to be further evaluated." . . "Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction" . . . "Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction"@en . . "Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction"@en . "RIV/00023001:_____/09:00001968" . . . . "8"^^ . "Apolipoprotein E Arg136 -> Cys in individuals with premature myocardial infarction" . "6"^^ . "55" . "[86E5CF2FE181]" . . "Aschermann, M." . . . "4"^^ .